Progress in Cardiovascular Diseases
Papers 2283
1 page of 229 pages (2,283 results)
#1Jari A. Laukkanen (University of Jyväskylä)H-Index: 34
#2Setor K. Kunutsor (UoB: University of Bristol)H-Index: 26
Last.Carl J. Lavie (UQ: University of Queensland)H-Index: 82
view all 7 authors...
Abstract A large body of evidence demonstrates positive, graded effects of PA on cardiovascular disease (CVD) morbidity and mortality with increasing intensity compared with lower PA intensity. Running is often designated as a high-intensity PA with substantial evidence supporting its health benefits. Cross-country skiing is among the most demanding aerobic endurance exercises and requires engaging the upper- and lower-body. Cross-country skiing is often regarded as high-intensity PA, which has ...
#1Serge Harb (Cleveland Clinic)H-Index: 8
#2Samir Kapadia (Cleveland Clinic)H-Index: 74
Abstract Tricuspid regurgitation (TR) is a common valvular pathology and is associated with significant morbidity and mortality. However, there is no currently defined optimal management strategy: medical therapy is limited to diuretics, and tricuspid valve surgery is rarely performed and associated with high risks. This has led to the emergence of numerous transcatheter therapies that are showing promising early results but are faced with multiple challenges. The tricuspid valve anatomy is comp...
#1Vinay Garg (U of T: University of Toronto)H-Index: 1
#2Subodh Verma (U of T: University of Toronto)H-Index: 68
Last.A ConnellyKim (U of T: University of Toronto)H-Index: 31
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Abstract The treatment landscape for patients with established or at high risk for cardiovascular disease and type 2 diabetes mellitus has entirely changed over the past decade, with the introduction of several anti-hyperglycemic agents. Sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) agonists are two anti-hyperglycemic classes which have been of special interest after multiple large cardiovascular disease (CVD) outcomes studies have demonstrated superiority...
#1James H. O'Keefe (UMKC: University of Missouri–Kansas City)H-Index: 52
#2Michael E. Nassif (UMKC: University of Missouri–Kansas City)H-Index: 11
Last.Carl J. Lavie (UQ: University of Queensland)H-Index: 82
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Abstract Type 2 Diabetes (T2D) is a growing public health threat that is evolving into a global pandemic with debilitating, expensive and often lethal complications. Even when hemoglobin A1c (HbA1C) levels are well controlled, and concomitant cardiovascular (CV) risk factors are effectively treated, two out of every three patients with T2D are destined to die from CV complications.
#1Eugene Braunwald (Brigham and Women's Hospital)H-Index: 208
Abstract The prevalence of Type 2 diabetes mellitus (T2DM) has reached pandemic proportions. T2DM frequently causes macrovascular and/or microvascular pathologic changes and thereby increases the risks for the development of myocardial infarction, heart failure, stroke, renal failure, and reduced survival. This article describes the important interactions between T2DM, heart failure, and renal dysfunction, forming vicious circles. The interruption of these circles represent important therapeutic...
#1Tushar Acharya (UA: University of Arizona)H-Index: 6
#2Prakash Deedwania (UCSF: University of California, San Francisco)H-Index: 66
Abstract Concerns of elevated cardiovascular disease (CVD) risk with some anti-diabetic medications warranted phase 4 clinical trials to demonstrate CVD safety of newly marketed anti-diabetic drugs. Although initially designed to evaluate safety, some of these CVD outcome trials (CVOTs) have in fact shown CVD benefits. New medication classes, like glucagon-like peptide 1 (GLP-1) analogues and sodium-glucose co-transporter 2 (SGLT2) inhibitors, have shown reductions in the risk of major adverse c...
#1Manasvi Gupta (UConn: University of Connecticut)
#2Ramyashree Tummala (Beth Israel Medical Center)
Last.Prakash Deedwania (UCSF: University of California, San Francisco)H-Index: 66
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Abstract Hyperlipidemia plays a crucial role in the underlying pathogenesis of multiple cardiovascular diseases (CVD), including coronary artery disease, peripheral arterial disease, carotid stenosis, and heart failure. The risk of developing such diseases in the diabetic population is relatively high. Diabetes mellitus (DM) is an independent risk factor for premature atherosclerosis. The hallmark of DM dyslipidemia is a demonstrably high level of atherogenic triglyceride rich lipids including v...
#1Salvatore Carbone (VCU: Virginia Commonwealth University)H-Index: 14
#2Marco Giuseppe Del Buono (UCSC: Catholic University of the Sacred Heart)
Last.Carl J. Lavie (UQ: University of Queensland)H-Index: 82
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Abstract The epidemic of obesity contributes to the burden of type 2 diabetes mellitus (T2DM) in the United States and worldwide. Importantly, obesity is not only preventable but can be treated, particularly with lifestyle modifications to forestall T2DM in those with excess adiposity. The mechanisms linking obesity to T2DM are numerous and involve adipose tissue remodeling as a result of unhealthy behaviors, including unhealthy diet, reduced physical activity (PA) and exercise training (ET), an...