Recent advances in headache neuroimaging

Published on Aug 1, 2018in Current Opinion in Neurology4.647
· DOI :10.1097/WCO.0000000000000573
Roberta Messina9
Estimated H-index: 9
(UniSR: Vita-Salute San Raffaele University),
Massimo Filippi118
Estimated H-index: 118
(UniSR: Vita-Salute San Raffaele University),
Peter J. Goadsby111
Estimated H-index: 111
Purpose of reviewPrimary headaches, such as migraine and cluster headache, are one of the most common and disabling neurological diseases worldwide. Neuroimaging studies have changed the way we understand these diseases and have enriched our knowledge of the mechanisms of actions of currently availa
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#1Roberta MessinaH-Index: 9
#2Massimo Filippi (UniSR: Vita-Salute San Raffaele University)H-Index: 118
#1Roberta MessinaH-Index: 9
#2Maria A. RoccaH-Index: 71
Last. Massimo FilippiH-Index: 118
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Resting state (RS) functional connectivity (FC) abnormalities of brain networks involved in pain- and multisensory processing have been disclosed in adult-migraine patients. We explored RS FC of large-scale brain networks in pediatric-migraine patients and their correlation with patients’ clinical characteristics. RS functional MRI data was acquired from 13 pediatric-migraine patients and 14 age- and sex-matched controls. Intra- and inter-network RS FC differences between patients and controls w...
#1Maria A. RoccaH-Index: 71
#2Judith U. Harrer (UniSR: Vita-Salute San Raffaele University)
Last. Massimo FilippiH-Index: 118
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One of the most exciting developments in modern neuroscience has been the expansion of imaging techniques that can provide insights into human brain structures and networks that could be involved in the pathophysiology of diseases. A series of MRI techniques have been extensively applied to the study of patients with migraine. It is now widely accepted that migraine should be viewed as a complex brain network disorder with a strong genetic basis that involves the interplay of multiple neuronal s...
#1Yiheng TuH-Index: 7
#2Fang ZengH-Index: 14
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Objective To identify and validate an fMRI-based neural marker for migraine without aura (MwoA) and to examine its association with treatment response. Methods We conducted cross-sectional studies with resting-state fMRI data from 230 participants and machine learning analyses. In studies 1 through 3, we identified, cross-validated, independently validated, and cross-sectionally validated an fMRI-based neural marker for MwoA. In study 4, we assessed the relationship between the neural marker and...
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Chronic migraine is a highly disabling disease with a great impact on socioeconomic functioning and quality of life of migraine patients. Chronic migraine usually evolves from episodic migraine that gradually increases in attack frequency, supporting the view of migraine as a spectrum disorder. Pathophysiological mechanisms responsible for migraine chronification are not fully understood. Likewise episodic migraine, chronic migraine patients showed widespread functional and structural alteration...
#1Kyong Jin Shin (Inje University)H-Index: 7
#2Ho-Joon Lee (Inje University)H-Index: 1
Last. Kang Min Park (Inje University)H-Index: 5
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The aim of this study is to investigate the alterations of thalamic nuclei volumes and the intrinsic thalamic network in patients with migraine. We enrolled 35 patients with migraine without aura and 40 healthy controls. All subjects underwent three-dimensional T1-weighted imaging. The thalamic nuclei were segmented using the FreeSurfer program. We investigated volume changes of individual thalamic nuclei and analyzed the alterations of the intrinsic thalamic network based on volumes in the pati...
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#2Roberta Messina (UniSR: Vita-Salute San Raffaele University)H-Index: 9
Last. Massimo Filippi (UniSR: Vita-Salute San Raffaele University)H-Index: 118
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In the last 20 years, we observed significant improvements in the use of magnetic resonance imaging (MRI) for the evaluation of patients affected by migraine. Before these technological advances, knowledge of the pathogenesis of migraine was particularly based on clinical assessment. Complementary to clinical evaluation, conventional MRI provides both specific information for differential diagnosis (particularly if cortical or subcortical lesions are detected in the migrainous brain) and unsurpa...
#1Anne Luise Haulund Vollesen (UCPH: University of Copenhagen)H-Index: 7
#2Silvia Benemei (UniFI: University of Florence)H-Index: 26
Last. Christian LamplH-Index: 21
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Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one p...
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