Massimo Filippi
Vita-Salute San Raffaele University
PathologyMagnetic resonance imagingPhysical therapyMultiple sclerosisMedicine
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Publications 1449
#1Massimo Filippi (UniSR: Vita-Salute San Raffaele University)H-Index: 118
#2Silvia BasaiaH-Index: 6
Last. Vladana Markovic (University of Belgrade)H-Index: 6
view all 12 authors...
Longitudinal connectivity studies might guide our understanding of the underlying neurodegenerative processes. We report the results of a longitudinal study in patients at different stages of Parkinson’s disease (PD), who performed motor and non-motor evaluations and serial resting state (RS) functional MRI (fMRI). Cluster analysis was applied to demographic and clinical data of 146 PD patients to define disease subtypes. Brain network functional alterations were assessed at baseline in PD relat...
#1Massimo FilippiH-Index: 118
#2Camilla Cividini (UniSR: Vita-Salute San Raffaele University)H-Index: 1
Last. Federica Agosta (UniSR: Vita-Salute San Raffaele University)H-Index: 57
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#1Svenja Kiljan (VUmc: VU University Medical Center)
#2P Preziosa (VUmc: VU University Medical Center)H-Index: 1
Last. Jeroen J. G. Geurts (VUmc: VU University Medical Center)H-Index: 58
view all 11 authors...
BACKGROUND: Neuroaxonal degeneration is one of the hallmarks of clinical deterioration in progressive multiple sclerosis (PMS). OBJECTIVE: To elucidate the association between neuroaxonal degeneration and both local cortical and connected white matter (WM) tract pathology in PMS. METHODS: Post-mortem in situ 3T magnetic resonance imaging (MRI) and cortical tissue blocks were collected from 16 PMS donors and 10 controls. Cortical neuroaxonal, myelin, and microglia densities were quantified histop...
Although the genetic architecture of amyotrophic lateral sclerosis (ALS) is incompletely understood, recent findings suggest a complex model of inheritance in ALS, which is consistent with a multistep pathogenetic process. Therefore, the aim of our work is to further explore the architecture of ALS using targeted next generation sequencing (NGS) analysis, enriched in motor neuron diseases (MND)-associated genes which are also implicated in axonal hereditary motor neuropathy (HMN), in order to in...
#1Elisabetta Sarasso (UniSR: Vita-Salute San Raffaele University)H-Index: 4
#2Federica Agosta (UniSR: Vita-Salute San Raffaele University)H-Index: 57
Last. Massimo FilippiH-Index: 118
view all 4 authors...
The current review summarizes the current knowledge on longitudinal cortical and subcortical grey and white matter MRI findings assessed using T1-weighted and one-tensor diffusion-weighted MRI in Parkinson's disease (PD) patients. Results were reviewed according to disease duration, disease severity and cognitive impairment. The most consistent findings are those showing a progressive cortical atrophy accumulation in caudate, putamen, temporal/hippocampal, frontal and parietal areas in de novo P...
#2Yuri M. FalzoneH-Index: 5
Last. Ubaldo Del CarroH-Index: 26
view all 7 authors...
#1Maria A. RoccaH-Index: 71
#2Laura Cacciaguerra (UniSR: Vita-Salute San Raffaele University)H-Index: 1
Last. Massimo FilippiH-Index: 118
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Introduction. With the advent of targeted drugs, a correct identification of patients with neuromyelitis optica spectrum disorders (NMOSD) is fundamental. Moreover, to assess treatment efficacy, se...
#1Paolo PreziosaH-Index: 15
#2Maria A. RoccaH-Index: 71
Last. Massimo FilippiH-Index: 118
view all 3 authors...
Introduction: Neurodegenerative processes occur from the beginning of multiple sclerosis, contribute to irreversible clinical disability and are only partially addressed by current disease-modifyin...
Here, we explored trajectories of sub-regional thalamic resting state (RS) functional connectivity (FC) modifications occurring in clinically isolated syndrome (CIS) patients early after their first clinical episode, and assessed their relationship with disability over 7 years. RS fMRI and clinical data were prospectively acquired from 59 CIS patients and 13 healthy controls (HC) over 2 years. A clinical re-assessment was performed in 53 (89%) patients after 7 years. Using a structural connectiv...