Current Opinion in Neurology
Papers 2508
1 page of 251 pages (2,508 results)
#1Martina Absinta (Johns Hopkins University)
#2Hans Lassmann (Medical University of Vienna)H-Index: 138
Last. Bruce D. Trapp (Cleveland Clinic)H-Index: 64
view all 3 authors...
PURPOSE OF REVIEW: In multiple sclerosis, currently approved disease-modifying treatments are effective in modulating peripheral immunity, and coherently, in reducing clinical/radiological relapses, but still, they perform poorly in preventing disease progression and overall disability accrual. This review provides an up-to-date overview of the neuropathology of progressive multiple sclerosis, including a summary of the main mechanisms of disease progression. RECENT FINDINGS: Clinical progressio...
#1Bruce T. Volpe (The Feinstein Institute for Medical Research)H-Index: 71
PURPOSE OF REVIEW: Recently, experiments show that the autoantibodies with direct access to neurons following blood brain barrier (BBB) disruption destroy neurons and lead to remodeling in damaged neurons. These are critical steps in autoantibody-mediated central nervous system disorder called neuropsychiatric syndromes in systemic lupus erythematosus (NPSLE). The purpose of this review is to examine therapeutic opportunities to repress neuronal remodeling by microglia after acute neuronal injur...
#1Chu-Yueh Guo (UCSF: University of California, San Francisco)
#2Jeffrey M. GelfandH-Index: 30
Last. Michael D. GeschwindH-Index: 39
view all 3 authors...
PURPOSE OF REVIEW: To systematically review the clinical features, diagnosis, and management of anti-gamma-aminobutyric acid receptor Type A (GABAA) autoimmune encephalitis with a focus on recent data. RECENT FINDINGS: In a review of published reports, we identified 50 cases of anti-GABAA receptor encephalitis with clinical features reported. The median age at presentation was 47 years old (range, 2.5 months-88 years old), 64% were adults, 36% were children and it occurred in both males and fema...
#1Simone Mader (LMU: Ludwig Maximilian University of Munich)H-Index: 1
#2Tania KümpfelH-Index: 35
Last. Edgar MeinlH-Index: 55
view all 3 authors...
PURPOSE OF REVIEW: This review summarizes recent insights into the pathogenesis and therapeutic options for patients with MOG- or AQP4-antibodies. RECENT FINDINGS: Although AQP4-IgG are linked to NMOSD, MOG-IgG-associated diseases (MOGAD) include a broader clinical spectrum of autoimmune brain disease. Details of membrane assembly of AQP4-IgG required for complement activation have been uncovered. Affinity-purified MOG-IgG from patients were shown to be pathogenic by induction of demyelination w...
#1Diego CentonzeH-Index: 71
#2Letizia Leocani (UniSR: Vita-Salute San Raffaele University)H-Index: 11
Last. Peter Feys (Reval)H-Index: 30
view all 3 authors...
PURPOSE OF REVIEW: Multiple sclerosis (MS) is a neurological disorder that heavily affects quality of life (QoL) and demands a multidisciplinary therapeutic approach. This includes multiple protocols and techniques of physical rehabilitation, ranging from conventional exercise paradigms to noninvasive brain stimulation (NIBS). Recently, studies showing the clinical efficacy of physical rehabilitation have remarkably increased, suggesting its disease-modifying potential. RECENT FINDINGS: Studies ...
PURPOSE OF REVIEW: Posttraumatic headache (PTH) attributed to mild traumatic brain injury is common and debilitating. In up to one-half of those with acute PTH, the PTH becomes persistent (PTH), enduring for longer than 3 months. The high incidence and persistence of PTH necessitate research into PTH pathophysiology and treatment. In this review, recent developments regarding the diagnostic criteria for PTH, the pathophysiology of PTH, and PTH treatment are discussed. RECENT FINDINGS: Internatio...
#1David Moreno‐Ajona (University of Cambridge)H-Index: 1
#2Abigail Perez-Rodriguez (University of Cambridge)
Last. Peter J. Goadsby (University of Cambridge)H-Index: 111
view all 3 authors...
PURPOSE OF REVIEW: Migraine is the second leading cause of years lived with disability after back pain. Poor tolerability, contraindications, drug-drug interactions and efficacy limited to a subpopulation make new approaches necessary for the acute and preventive treatment of migraine. The study of the calcitonin-gene-related peptide (CGRP) pathway over the last decades is a good example of translational medicine leading to directed therapies for patients. RECENT FINDINGS: After some of the firs...
#1Paul M. Matthews (Imperial College London)H-Index: 165
#2Valerie Block (UCSF: University of California, San Francisco)H-Index: 2
Last. Letizia LeocaniH-Index: 29
view all 3 authors...
PURPOSE OF REVIEW: To outline recent applications of e-health data and digital tools for improving the care and management of healthcare for people with multiple sclerosis. RECENT FINDINGS: The digitization of most clinical data, along with developments in communication technologies, miniaturization of sensors and computational advances are enabling aggregation and clinically meaningful analyses of real-world data from patient registries, digital patient-reported outcomes and electronic health r...
#1Lucia Moiola (UniSR: Vita-Salute San Raffaele University)H-Index: 31
#2Paulus S. Rommer (Medical University of Vienna)H-Index: 16
Last. Uwe K. Zettl (University of Rostock)H-Index: 41
view all 3 authors...
PURPOSE OF REVIEW: To summarize the currently known side effects of the approved therapies of multiple sclerosis and to suggest monitoring procedures. RECENT FINDINGS: The progress in the treatment of multiple sclerosis with new very effective therapies is accompanied by a number of side effects. Some of these have already been described in the approval studies, but some only after approval in a real world situation. The reason for this is the short duration of the clinical studies, the very het...
Top fields of study
Multiple sclerosis