Peter J. Goadsby
King's College London
Physical therapyCluster headacheMigraineAnesthesiaMedicine
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Publications 1109
#1David Moreno‐Ajona (University of Cambridge)H-Index: 1
#2Abigail Perez-Rodriguez (University of Cambridge)
Last. Peter J. Goadsby (University of Cambridge)H-Index: 111
view all 3 authors...
PURPOSE OF REVIEW: Migraine is the second leading cause of years lived with disability after back pain. Poor tolerability, contraindications, drug-drug interactions and efficacy limited to a subpopulation make new approaches necessary for the acute and preventive treatment of migraine. The study of the calcitonin-gene-related peptide (CGRP) pathway over the last decades is a good example of translational medicine leading to directed therapies for patients. RECENT FINDINGS: After some of the firs...
#1David KernickH-Index: 10
#2Peter J. GoadsbyH-Index: 111
#1Calvin Chan (University of Cambridge)H-Index: 2
#2Peter J. Goadsby (University of Cambridge)H-Index: 111
IntroductionCurrent treatment options for the prevention of cluster headache are largely unsatisfactory. The therapies have a limited evidence base and often significant side effects issues. The involvement of the calcitonin gene-related peptide (CGRP) pathway in primary headache disorders, especially migraine, had led to recent success in the development of new migraine therapies. The CGRP pathway also plays a role in the pathophysiology of cluster headache, so CGRP pathway monoclonal antibodie...
#1R Mahon (Novartis)H-Index: 2
#2Jasper Huels (Novartis)H-Index: 6
Last. Stephen Palmer (Ebor: University of York)H-Index: 49
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Background: For novel migraine therapies, economic evaluations will be required to understand the trade-offs between additional health benefit and additional cost. The purpose of this study was to conduct a systematic literature review (SLR) to identify previous economic evaluations in migraine from the United Kingdom or Irish perspective to critically appraise these evaluations and to propose, if necessary, a novel modelling approach that can be used for future economic evaluations of migraine ...
#1Peter J. Goadsby ('KCL': King's College London)H-Index: 111
#2Stefan Evers (WWU: University of Münster)H-Index: 57
#1Harutomo Hasegawa (University of Cambridge)H-Index: 4
#2Richard Selway (University of Cambridge)H-Index: 25
Last. Keyoumars Ashkan (University of Cambridge)H-Index: 27
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Summary Early studies posited a relationship between sleep and the basal ganglia, but this relationship has received little attention recently. It is timely to revisit this relationship, given new insights into the functional anatomy of the basal ganglia and the physiology of sleep, which has been made possible by modern techniques such as chemogenetic and optogenetic mapping of neural circuits in rodents and intracranial recording, functional imaging, and a better understanding of human sleep d...
#1Dimitris Sakellariou ('KCL': King's College London)H-Index: 2
#2Alexander NesbittH-Index: 4
Last. Adrian J. Williams (Guy's and St Thomas' NHS Foundation Trust)H-Index: 25
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BACKGROUND: Exploding head syndrome is a rarely reported benign sensory parasomnia that may nonetheless have significant impact on patients' quality of life and their perceived well-being. To date, the mechanisms underlying attacks, characterised by a painless perception of abrupt, loud noises at transitional sleep-wake or wake-sleep states, are by and large unclear. METHODS AND RESULTS: In order to address the current gap in the knowledge of potential underlying pathophysiology, a retrospective...
#1Anthony Khoo (Royal Adelaide Hospital)H-Index: 1
#2Michelle Kiley (Royal Adelaide Hospital)H-Index: 5
Last. Peter J. Goadsby (NIHR: National Institute for Health Research)H-Index: 111
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The management of external cold-stimulus headache has previously focused on trigger avoidance, which can be an impractical and sometimes impossible solution. We describe the case of a 20-year-old w...
#1Dustin D. Ruff (Eli Lilly and Company)H-Index: 12
#2Janet H. Ford (Eli Lilly and Company)H-Index: 4
Last. Peter J. Goadsby ('KCL': King's College London)H-Index: 111
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BACKGROUND AND PURPOSE: The efficacy of galcanezumab, a monoclonal antibody for migraine prevention, has been demonstrated in two pivotal trials in patients with episodic migraine. METHODS: EVOLVE-1 and EVOLVE-2 were identical phase 3, randomized, double-blind, placebo-controlled studies in patients with episodic migraine. Mean migraine headache days per month at baseline was 9. Patients were randomized 2:1:1 to monthly injections of placebo, galcanezumab 120 mg/240 mg during the 6-month double-...
4 CitationsSource
#1Christoph J. Schankin (University of Bern)H-Index: 21
#2Farooq H. Maniyar (QMUL: Queen Mary University of London)H-Index: 8
Last. Peter J. Goadsby (UCSF: University of California, San Francisco)H-Index: 111
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Patients with visual snow syndrome suffer from a continuous pan-field visual disturbance, additional visual symptoms, tinnitus, and non-perceptional symptoms. The pathophysiology of visual symptoms might involve dysfunctional visual cortex. So far, the extra-visual system has not been investigated. We aimed at identifying structural and functional correlates for visual and non-visual symptoms in visual snow syndrome. Patients were compared to age- and sex-matched controls using 18F-2-fluoro-2-de...