Longitudinal diffusion tensor imaging changes in early Parkinson’s disease: ICICLE-PD study

To investigate whether white matter microstructural changes can be used as a predictor of worsening of motor features or cognitive decline in patients with Parkinson’s disease and verify whether white matter microstructural longitudinal changes differ between patients with Parkinson’s disease with normal cognition and those with mild cognitive impairment. We enrolled 120 newly diagnosed patients with early stage Parkinson’s disease (27 with mild...