Thais Minett
University of Cambridge
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Publications 100
#1Sally Hunter (University of Cambridge)H-Index: 12
#2Suvi R.K. Hokkanen (University of Cambridge)H-Index: 4
Last. Carol Brayne (University of Cambridge)H-Index: 106
view all 8 authors...
Pathologies associated with the Tar-DNA binding protein 43 KDa (TDP-43) are associated with neurodegenerative diseases and aging. Phosphorylation of cellular proteins is a well-accepted mechanism of biological control and can be associated with disease pathways. Phosphorylation state associated with TDP-43 associated pathology has not been investigated with respect to dementia status in a population representative sample. TDP-43 immunohistochemistry directed toward phosphorylated (TDP-43P) and u...
#1Thais MinettH-Index: 19
Last. Henrique Ballalai FerrazH-Index: 21
view all 4 authors...
#1Suvi R.K. Hokkanen (University of Cambridge)H-Index: 4
#2Sally Hunter (University of Cambridge)H-Index: 12
Last. Carol Brayne (University of Cambridge)H-Index: 106
view all 7 authors...
The Cambridge Human Research Tissue Bank is supported by the National Institute for Health Research Cambridge Biomedical Research Centre. CFAS is supported by grants (G9901400) from the UK Medical Research Council MRC CFAS was supported in part by: a Special Project grant and a Programme grant from the MRC and the Department of Health; the UK NIHR Biomedical Research Centre for Ageing and Age - related Disease Award to the Newcastle-upon-Tyne Hospitals Foundation Trust; the Cambridge Brain Bank ...
6 CitationsSource
#1Thais Minett (University of Cambridge)H-Index: 19
#2Li Su (University of Cambridge)H-Index: 16
Last. John T. O'Brien (University of Cambridge)H-Index: 101
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Objective To investigate whether white matter microstructural changes can be used as a predictor of worsening of motor features or cognitive decline in patients with Parkinson’s disease and verify whether white matter microstructural longitudinal changes differ between patients with Parkinson’s disease with normal cognition and those with mild cognitive impairment.
4 CitationsSource
#1Maysa Luchesi Cera (UnB: University of Brasília)H-Index: 1
#2Karin Zazo Ortiz (UNIFESP: Federal University of São Paulo)H-Index: 13
Last. Thais Minett (University of Cambridge)H-Index: 19
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ABSTRACTBackground: Alzheimer’s disease (AD) can involve changes in communication and can lead to mutism in severe cases. Oral communication may be impaired by phonetic-motor disorders, such as apraxia of speech (AOS), or by language disorders, such as aphasia. Therefore, the identification of manifestations of AOS and phonemic paraphasias in patients with AD is critical to understanding the communication changes and determining the therapeutic planning.Aims: To identify the distribution of phon...
1 CitationsSource
#2Thais MinettH-Index: 19
Last. Leslie R. BridgesH-Index: 12
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Background and Purpose— We tested whether blood–brain barrier dysfunction in subcortical white matter is associated with white matter abnormalities or risk of clinical dementia in older people (n=126; mean age 86.4, SD: 7.7 years) in the MRC CFAS (Medical Research Council Cognitive Function and Ageing Study). Methods— Using digital pathology, we quantified blood–brain barrier dysfunction (defined by immunohistochemical labeling for the plasma marker fibrinogen). This was assessed within subcorti...
15 CitationsSource
#1Blossom Christa Maree Stephan (Newcastle University)H-Index: 5
#2Thais Minett (University of Cambridge)H-Index: 19
Last. Carol Brayne (University of Cambridge)H-Index: 106
view all 6 authors...
MRC CFAS has been funded by the Medical Research Council (G9901400) and Department of Health.
4 CitationsSource
#1Paul G. Ince (University of Sheffield)H-Index: 81
#2Thais Minett (University of Cambridge)H-Index: 19
Last. Stephen B. Wharton (University of Sheffield)H-Index: 41
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Introduction Microinfarcts, small ischaemic foci common in ageing brain, are associated with dementia and gait dysfunction. We determined their relationship to dementia, mobility and cerebrovascular disease in an older population-representative brain donor cohort. These data on microinfarcts were evaluated in relation to pathological assessments of clinically significant cerebral small vessel disease (SVD). Methods Microinfarcts were assessed in the MRC Cognitive Function and Ageing Study (n=331...
13 CitationsSource