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Hippocampal and entorhinal cortex volume changes in Alzheimer's disease patients and mild cognitive impairment subjects

Published on Mar 1, 2018
· DOI :10.1109/bhi.2018.8333412
Stephanos Leandrou1
Estimated H-index: 1
(European University Cyprus),
I. Mamais (European University Cyprus)+ 3 AuthorsConstantinos S. Pattichis34
Estimated H-index: 34
(University of Cyprus)
Hippocampal and entorhinal cortex as scanned in Magnetic Resonance Imaging (MRI), are two of the most commonly used Regions of Interest (ROIs) for the assessment of Alzheimer's disease (AD). Both structures are used for the classification between Normal Controls (NC), Mild Cognitive Impairment (MCI) and AD subjects and for the disease prognosis. The objective of this study was to evaluate how the volume of these two structures changes between the following groups: NC vs AD, NC vs MCI, MCI vs MCI converters (MCIc — subjects who had converted to AD within 48 months), and AD vs MCIc subjects. Both structures were significantly reduced in volume for MCIc and AD subjects compared to NC. For both MCI and MCIc groups, the atrophy rate was correlated for both structures. In AD subjects, entorhinal cortex was more affected by atrophy. In conclusion, structural MRI and volumetric measurements of the hippocampus and entorhinal cortex can be used as early signs for the assessment of AD, and this is in agreement with previous studies.
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Published on Feb 1, 2010in Nature Reviews Neurology 19.82
Giovanni B. Frisoni81
Estimated H-index: 81
Nick C. Fox112
Estimated H-index: 112
(University College London)
+ 2 AuthorsPaul M. Thompson129
Estimated H-index: 129
(University of California, Los Angeles)
Structural imaging based on magnetic resonance is an integral part of the clinical assessment of patients with suspected Alzheimer dementia. Prospective data on the natural history of change in structural markers from preclinical to overt stages of Alzheimer disease are radically changing how the disease is conceptualized, and will influence its future diagnosis and treatment. Atrophy of medial temporal structures is now considered to be a valid diagnostic marker at the mild cognitive impairment...
761 Citations Source Cite
Published on Aug 11, 2009in Neurology 8.05
Carrie R. McDonald28
Estimated H-index: 28
Linda K. McEvoy50
Estimated H-index: 50
+ 6 AuthorsAnders M. Dale122
Estimated H-index: 122
Objective: To evaluate the spatial pattern and regional rates of neocortical atrophy from normal aging to early Alzheimer disease (AD). Methods: Longitudinal MRI data were analyzed using high-throughput image analysis procedures for 472 individuals diagnosed as normal, mild cognitive impairment (MCI), or AD. Participants were divided into 4 groups based on Clinical Dementia Rating Sum of Boxes score (CDR-SB). Annual atrophy rates were derived by calculating percent cortical volume loss between b...
184 Citations Source Cite
Published on Apr 1, 2008in Journal of Magnetic Resonance Imaging 3.61
Clifford R Jr. Jack133
Estimated H-index: 133
(Mayo Clinic),
Matthew A Bernstein41
Estimated H-index: 41
(Mayo Clinic)
+ 32 AuthorsChadwick P. Ward11
Estimated H-index: 11
(Mayo Clinic)
Dementia, one of the most feared associates of increasing longevity, represents a pressing public health problem and major research priority. Alzheimer's disease (AD) is the most common form of dementia, affecting many millions around the world. There is currently no cure for AD, but large numbers of novel compounds are currently under development that have the potential to modify the course of the disease and slow its progression. There is a pressing need for imaging biomarkers to improve under...
1,788 Citations Source Cite
Published on Jan 1, 2008in Neurobiology of Aging 4.45
Tero Tapiola3
Estimated H-index: 3
Corina Pennanen10
Estimated H-index: 10
+ 14 AuthorsAnne Hämäläinen6
Estimated H-index: 6
The concept of mild cognitive impairment (MCI) has been proposed to represent a transitional stage between normal aging and dementia. We studied the predictive value of the MRI-derived volumes of medial temporal lobe (MTL) structures, white matter lesions (WML), neuropsychological tests, and Apolipoprotein E (APOE) genotype on conversion of MCI to dementia and AD. The study included 60 subjects with MCI identified from population cohorts. During the mean follow-up period of 34 months, 13 patient...
110 Citations Source Cite
Published on Aug 1, 2007in Lancet Neurology 27.14
Bruno Dubois104
Estimated H-index: 104
(Pierre-and-Marie-Curie University),
Howard Feldman67
Estimated H-index: 67
(University of British Columbia)
+ 16 AuthorsGregory A. Jicha44
Estimated H-index: 44
(University of Kentucky)
Summary The NINCDS–ADRDA and the DSM-IV-TR criteria for Alzheimer's disease (AD) are the prevailing diagnostic standards in research; however, they have now fallen behind the unprecedented growth of scientific knowledge. Distinctive and reliable biomarkers of AD are now available through structural MRI, molecular neuroimaging with PET, and cerebrospinal fluid analyses. This progress provides the impetus for our proposal of revised diagnostic criteria for AD. Our framework was developed to captur...
2,762 Citations Source Cite
Published on Mar 13, 2007in Neurology 8.05
D.P. Devanand60
Estimated H-index: 60
Gnanavalli Pradhaban6
Estimated H-index: 6
+ 10 AuthorsRichard Mayeux128
Estimated H-index: 128
Objective: To evaluate the utility of MRI hippocampal and entorhinal cortex atrophy in predicting conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD). Methods: Baseline brain MRI was performed in 139 patients with MCI, broadly defined, and 63 healthy controls followed for an average of 5 years (range 1 to 9 years). Results: Hippocampal and entorhinal cortex volumes were each largest in controls, intermediate in MCI nonconverters, and smallest in MCI converters to AD (37 of ...
446 Citations Source Cite
Published on Apr 1, 2006in NeuroImage 5.43
Jorge Jovicich23
Estimated H-index: 23
(Massachusetts Institute of Technology),
Silvester Czanner6
Estimated H-index: 6
(Massachusetts Institute of Technology)
+ 9 AuthorsJames R. MacFall63
Estimated H-index: 63
(Duke University)
Abstract Longitudinal and multi-site clinical studies create the imperative to characterize and correct technological sources of variance that limit image reproducibility in high-resolution structural MRI studies, thus facilitating precise, quantitative, platform-independent, multi-site evaluation. In this work, we investigated the effects that imaging gradient non-linearity have on reproducibility of multi-site human MRI. We applied an image distortion correction method based on spherical harmo...
722 Citations Source Cite
Published on Jul 21, 2004in Annual Review of Neuroscience 14.68
Larry R. Squire128
Estimated H-index: 128
(University of California, San Diego),
Craig E.L. Stark42
Estimated H-index: 42
(University of California, San Diego),
Robert E. Clark36
Estimated H-index: 36
(University of California, San Diego)
▪ Abstract The medial temporal lobe includes a system of anatomically related structures that are essential for declarative memory (conscious memory for facts and events). The system consists of the hippocampal region (CA fields, dentate gyrus, and subicular complex) and the adjacent perirhinal, entorhinal, and parahippocampal cortices. Here, we review findings from humans, monkeys, and rodents that illuminate the function of these structures. Our analysis draws on studies of human memory impair...
1,920 Citations Source Cite
Published on Mar 1, 2004in Neurobiology of Aging 4.45
Corina Pennanen10
Estimated H-index: 10
Miia Kivipelto74
Estimated H-index: 74
+ 11 AuthorsEeva-Liisa Helkala47
Estimated H-index: 47
Abstract Magnetic resonance imaging (MRI) has been suggested as a useful tool in early diagnosis of Alzheimer’s disease (AD). Based on MRI-derived volumes, we studied the hippocampus and entorhinal cortex (ERC) in 59 controls, 65 individuals with mild cognitive impairment (MCI) and 48 patients with AD. The controls and individuals with MCI were derived from population-based cohorts. Volumes of the hippocampus and ERC were significantly reduced in the following order: control>MCI>AD. Stepwise dis...
406 Citations Source Cite
Published on Jan 1, 2004in Cerebral Cortex 6.31
Bruce Fischl92
Estimated H-index: 92
(Harvard University),
A. van der Kouwe39
Estimated H-index: 39
+ 11 AuthorsDavid N. Kennedy74
Estimated H-index: 74
We present a technique for automatically assigning a neuroanatomical label to each location on a cortical surface model based on probabilistic information estimated from a manually labeled training set. This procedure incorporates both geometric information derived from the cortical model, and neuroanatomical convention, as found in the training set. The result is a complete labeling of cortical sulci and gyri. Examples are given from two different training sets generated using different neuroan...
2,185 Citations Source Cite
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