Change in Odor Identification Impairment is Associated with Improvement with Cholinesterase Inhibitor Treatment in Mild Cognitive Impairment

Anticholinergic challenge can induce odor identification impairment that indicates Alzheimer's disease pathology.To determine if decline in odor identification ability with anticholinergic challenge can predict improvement with donepezil, a cholinesterase inhibitor (ChEI), in patients with mild cognitive impairment (MCI).At baseline, the University of Pennsylvania Smell identification Test (UPSIT) was administered before and after an...