Karen Bell
Charles Sturt University
Social workDementiaAlzheimer's diseaseMedicineBiology
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Publications 105
#2Howard F. AndrewsH-Index: 55
Last. Julianna PollinaH-Index: 1
view all 16 authors...
Introduction After infection, herpes simplex virus-1 (HSV1) becomes latent in the trigeminal ganglion and can enter the brain via retrograde axonal transport. Recurrent reactivation of HSV1 may lead to neurodegeneration and Alzheimer’s disease (AD) pathology. HSV1 (oral herpes) and HSV2 (genital herpes) can trigger amyloid beta-protein (Aβ) aggregation and HSV1 DNA is common in amyloid plaques. Anti-HSV drugs reduce Aβ and phosphorylated tau accumulation in cell-culture models. Cognitive impairm...
1 CitationsSource
#1Chris Moran (Monash University)H-Index: 9
#2Richard Beare (Monash University)H-Index: 24
Last. Balebail Ashok RajH-Index: 7
view all 254 authors...
Objective To study longitudinal relationships between type 2 diabetes mellitus (T2DM), cortical thickness, and cognitive function in older people with normal cognition, mild cognitive impairment, and Alzheimer disease (AD). Methods The sample was derived from the Alzheimer9s Disease Neuroimaging Initiative cohort who underwent brain MRI and cognitive tests annually for 5 years. Presence of T2DM was based on fasting blood glucose ≥7.0mml/L or the use of glucose-lowering agents. We used latent gro...
4 CitationsSource
#1Ines Mahjoub (University of Sousse)H-Index: 1
#2Mohamed Ali Mahjoub (University of Sousse)H-Index: 8
Last. Kristin Fargher (USF: University of South Florida)H-Index: 7
view all 241 authors...
Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer's disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the shape of cortical regions. However, 'shape connections' between brain regions are rarely investigated -e.g., how morphological attributes such as cortical thickness and sulcal depth of a specific brain region change in relation to morphological at...
24 CitationsSource
#1Lei Du (NPU: Northwestern Polytechnical University)H-Index: 7
#2Kefei Liu (IU: Indiana University)H-Index: 7
Last. Kristin Fargher (USF: University of South Florida)H-Index: 7
view all 310 authors...
Brain imaging genetics intends to uncover associations between genetic markers and neuroimaging quantitative traits. Sparse canonical correlation analysis (SCCA) can discover bi-multivariate associations and select relevant features, and is becoming popular in imaging genetic studies. The L1-norm function is not only convex, but also singular at the origin, which is a necessary condition for sparsity. Thus most SCCA methods impose ${\ell }_{{\bf{1}}} l 1 -norm onto the individual feature or t...
2 CitationsSource
#1Asha Singanamalli (Case Western Reserve University)H-Index: 5
#2Haibo Wang (Case Western Reserve University)H-Index: 15
Last. Kristin Fargher (USF: University of South Florida)H-Index: 7
view all 241 authors...
The introduction of mild cognitive impairment (MCI) as a diagnostic category adds to the challenges of diagnosing Alzheimer’s Disease (AD). No single marker has been proven to accurately categorize patients into their respective diagnostic groups. Thus, previous studies have attempted to develop fused predictors of AD and MCI. These studies have two main limitations. Most do not simultaneously consider all diagnostic categories and provide suboptimal fused representations using the same set of m...
4 CitationsSource
#2Cody LentzH-Index: 2
Last. Gregory H. PeltonH-Index: 18
view all 11 authors...
BACKGROUND: Anticholinergic challenge can induce odor identification impairment that indicates Alzheimer's disease pathology. OBJECTIVE: To determine if decline in odor identification ability with anticholinergic challenge can predict improvement with donepezil, a cholinesterase inhibitor (ChEI), in patients with mild cognitive impairment (MCI). METHODS: At baseline, the University of Pennsylvania Smell identification Test (UPSIT) was administered before and after an anticholinergic atropine nas...
2 CitationsSource
#1Jorge Munilla (UMA: University of Málaga)H-Index: 12
#2Andrés Ortiz (UMA: University of Málaga)H-Index: 16
Last. Steven Chao (UMA: University of Málaga)H-Index: 1
view all 351 authors...
Alzheimer’s Disease (AD) is the most common neurodegenerative disease in elderly people, and current drugs, unfortunately, do not represent yet a cure. This is explained, at least in part, because the understanding of the neurodegenerative process is still incomplete, being sometimes mistaken, particularly at the first steps of the illness, with the natural ageing process. A better identification of how the functional activity deteriorates is thus crucial to develop new and more effective treatm...
6 CitationsSource
#1Michel J. GrotheH-Index: 26
#2Sylvia VilleneuveH-Index: 17
Last. Balebail Ashok RajH-Index: 7
view all 256 authors...
Objective: To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach. Methods: Multimodal neuroimaging data were obtained from a total of 572 older individuals without dementia (cognitively normal and mild cognitive impairment) enrolled in the Alzheimer9s Disease Neuroimaging Initiative and included assessments of regional amyloid load with AV45-PET, glucose metabolism with fluorodeoxyglucose-PET, a...
12 CitationsSource
#1Meiyan Huang (Southern Medical University)H-Index: 1
#2Wei Yang (Southern Medical University)H-Index: 1
Last. Kristin Fargher (USF: University of South Florida)H-Index: 7
view all 242 authors...
Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease
20 CitationsSource
#1Taylor W. Schmitz (University of Cambridge)H-Index: 21
#2R. Nathan Spreng (Cornell University)H-Index: 33
Last. Ansgar J. FurstH-Index: 12
view all 312 authors...
Whether Alzheimer’s disease originates in basal forebrain or entorhinal cortex remains highly debated. Here the authors use structural magnetic resonance data from a longitudinal sample of participants stratified by cerebrospinal biomarker and clinical diagnosis to show that tissue volume changes appear earlier in the basal forebrain than in the entorhinal cortex.
75 CitationsSource