Protein-Restricted Diets for Ameliorating Motor Fluctuations in Parkinson's Disease

Levodopa is considered to be the most effective symptomatic drug for Parkinson’s disease (PD). As the disease progresses, however, the patients are likely to experience a reduced response to levodopa and develop motor fluctuations (i.e., end-of-dose wearing off and unpredictable “on-off”). Protein-rich diets and elevated plasma concentrations of large neutral amino acids have been proved to impair the therapeutic effect of levodopa by reducing...