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Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults—Randomized Controlled Trial

Published on Nov 1, 2016in EBioMedicine
· DOI :10.1016/j.ebiom.2016.10.036
Lotta Stenman5
Estimated H-index: 5
(DuPont),
Markus J. Lehtinen7
Estimated H-index: 7
(DuPont)
+ 12 AuthorsSampo J. Lahtinen28
Estimated H-index: 28
(DuPont)
Abstract
Abstract Background The gut microbiota is interlinked with obesity, but direct evidence of effects of its modulation on body fat mass is still scarce. We investigated the possible effects of Bifidobacterium animalis ssp. lactis 420 (B420) and the dietary fiber Litesse® Ultra polydextrose (LU) on body fat mass and other obesity-related parameters. Methods 225 healthy volunteers (healthy, BMI 28–34.9) were randomized into four groups (1:1:1:1), using a computer-generated sequence, for 6months of double-blind, parallel treatment: 1) Placebo, microcrystalline cellulose, 12g/d; 2) LU, 12g/d; 3) B420, 10 10 CFU/d in microcrystalline cellulose, 12g/d; 4) LU+B420, 12g+10 10 CFU/d. Body composition was monitored with dual-energy X-ray absorptiometry, and the primary outcome was relative change in body fat mass, comparing treatment groups to Placebo. Other outcomes included anthropometric measurements, food intake and blood and fecal biomarkers. The study was registered in Clinicaltrials.gov (NCT01978691). Findings There were marked differences in the results of the Intention-To-Treat (ITT; n =209) and Per Protocol (PP; n =134) study populations. The PP analysis included only those participants who completed the intervention with >80% product compliance and no antibiotic use. In addition, three participants were excluded from DXA analyses for PP due to a long delay between the end of intervention and the last DXA measurement. There were no significant differences between groups in body fat mass in the ITT population. However, LU+B420 and B420 seemed to improve weight management in the PP population. For relative change in body fat mass, LU+B420 showed a−4.5% (−1.4kg, P =0.02, N =37) difference to the Placebo group, whereas LU (+0.3%, P =1.00, N =35) and B420 (−3.0%, P =0.28, N =24) alone had no effect (overall ANOVA P =0.095, Placebo N =35). A post-hoc factorial analysis was significant for B420 (−4.0%, P =0.002 vs. Placebo). Changes in fat mass were most pronounced in the abdominal region, and were reflected by similar changes in waist circumference. B420 and LU+B420 also significantly reduced energy intake compared to Placebo. Changes in blood zonulin levels and hsCRP were associated with corresponding changes in trunk fat mass in the LU+B420 group and in the overall population. There were no differences between groups in the incidence of adverse events. Discussion This clinical trial demonstrates that a probiotic product with or without dietary fiber controls body fat mass. B420 and LU+B420 also reduced waist circumference and food intake, whereas LU alone had no effect on the measured outcomes.
  • References (49)
  • Citations (28)
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References49
Newest
Published on Feb 1, 2016in Beneficial Microbes 2.31
Lotta Stenman5
Estimated H-index: 5
(DuPont),
Rémy Burcelin65
Estimated H-index: 65
(French Institute of Health and Medical Research),
Sampo J. Lahtinen28
Estimated H-index: 28
(DuPont)
Changes in the gut microbiota are associated with metabolic disorders, such as overweight and elevated blood glucose. Mouse studies have shown that gut microbiota can regulate metabolism with a mechanism related to gut barrier function. An impaired gut barrier permits the translocation of bacteria and their components which, when in contact with the sub-mucosal immune system, evoke metabolic inflammation and distract signalling in metabolically active tissues. Despite thorough research of the to...
27 Citations Source Cite
Published on Dec 1, 2015in Diabetology & Metabolic Syndrome 2.41
Lotta Stenman5
Estimated H-index: 5
(DuPont),
Aurélie Waget25
Estimated H-index: 25
(French Institute of Health and Medical Research)
+ 4 AuthorsSampo J. Lahtinen28
Estimated H-index: 28
(DuPont)
Background Gut microbiota is now known to control glucose metabolism. Previous studies have shown that probiotics and prebiotics may improve glucose metabolism, but their effects have not been studied in combination with drug therapy. The aim of this study was to investigate whether probiotics and prebiotics combined with drug therapy affect diabetic outcomes.
16 Citations Source Cite
Published on Dec 1, 2015in Obesity 4.04
Kristin L. Osterberg5
Estimated H-index: 5
,
Nabil E. Boutagy8
Estimated H-index: 8
+ 6 AuthorsMatthew W. Hulver32
Estimated H-index: 32
Objective The objective was to determine the effects of the probiotic, VSL#3, on body and fat mass, insulin sensitivity, and skeletal muscle substrate oxidation following 4 weeks of a high-fat diet. Methods Twenty non-obese males (18-30 years) participated in the study. Following a 2-week eucaloric control diet, participants underwent dual X-ray absorptiometry to determine body composition, an intravenous glucose tolerance test to determine insulin sensitivity, and a skeletal muscle biopsy for m...
16 Citations Source Cite
Published on Jul 2, 2015in The New England Journal of Medicine 79.26
F. Xavier Pi-Sunyer76
Estimated H-index: 76
,
ArneV. Astrup1
Estimated H-index: 1
+ 8 AuthorsChristine Bjørn Jensen9
Estimated H-index: 9
BACKGROUND Obesity is a chronic disease with serious health consequences, but weight loss is difficult to maintain through lifestyle intervention alone. Liraglutide, a glucagonlike peptide-1 analogue, has been shown to have potential benefit for weight management at a once-daily dose of 3.0 mg, injected subcutaneously. METHODS We conducted a 56-week, double-blind trial involving 3731 patients who did not have type 2 diabetes and who had a body-mass index (BMI; the weight in kilograms divided by ...
421 Citations Source Cite
Published on Jul 1, 2015in Cell Metabolism 20.57
Lucile Garidou13
Estimated H-index: 13
(Paul Sabatier University),
Céline Pomié6
Estimated H-index: 6
(Paul Sabatier University)
+ 20 AuthorsSampo J. Lahtinen28
Estimated H-index: 28
Summary A high-fat diet (HFD) induces metabolic disease and low-grade metabolic inflammation in response to changes in the intestinal microbiota through as-yet-unknown mechanisms. Here, we show that a HFD-derived ileum microbiota is responsible for a decrease in Th17 cells of the lamina propria in axenic colonized mice. The HFD also changed the expression profiles of intestinal antigen-presenting cells and their ability to generate Th17 cells in vitro. Consistent with these data, the metabolic p...
88 Citations Source Cite
Published on Apr 1, 2015in Acta Diabetologica 3.13
K. A. Elisa Kallio4
Estimated H-index: 4
(University of Helsinki),
Katja A. Hätönen7
Estimated H-index: 7
(National Institute for Health and Welfare)
+ 3 AuthorsPirkko J. Pussinen41
Estimated H-index: 41
(University of Helsinki)
Aims Circulating lipopolysaccharides (LPSs), associated with both infection and inflammation, may arise from the gastrointestinal tract microbiota, and the levels may be affected by daily nutrition. We investigated whether nutrient intake affects the association of serum LPS activity with prevalent obesity, metabolic syndrome (MetS), diabetes, and coronary heart disease (CHD) and with the risk of incident CHD events.
41 Citations Source Cite
Published on Apr 1, 2015in Appetite 3.17
Alvin Ibarra14
Estimated H-index: 14
(DuPont),
Nerys M. Astbury12
Estimated H-index: 12
(Mount Sinai St. Luke's and Mount Sinai Roosevelt)
+ 2 AuthorsKirsti Tiihonen21
Estimated H-index: 21
(DuPont)
Abstract Introduction: Dietary fibers help to control energy intake and reduce the risk of developing obesity. Recent studies show that the consumption of polydextrose reduces energy intake at a subsequent meal. In this systematic review and meta-analysis we examine the subsequent effects of polydextrose on different levels of energy intake (EI). Method: The review followed the PRISMA methodology. Meta-analyses were expressed as Standardized Mean Difference (SMD). A linear regression approach wa...
13 Citations Source Cite
Published on Jan 1, 2015in Journal of Nutritional Science
Junichi Minami5
Estimated H-index: 5
,
Shizuki Kondo13
Estimated H-index: 13
+ 7 AuthorsTaeko Shimoda2
Estimated H-index: 2
Accumulating evidence suggests an association between gut microbiota and the development of obesity, raising the possibility of probiotic administration as a therapeutic approach. Bifidobacterium breve B-3 was found to exhibit an anti-obesity effect on high-fat diet-induced obesity mice. In the present study, a randomised, double-blind, placebo-controlled trial was conducted to evaluate the effect of the consumption of B. breve B-3 on body compositions and blood parameters in adults with a tende...
36 Citations Source Cite
Published on Dec 1, 2014in Beneficial Microbes 2.31
Lotta Stenman5
Estimated H-index: 5
(DuPont),
Aurélie Waget25
Estimated H-index: 25
(French Institute of Health and Medical Research)
+ 3 AuthorsSampo J. Lahtinen28
Estimated H-index: 28
(DuPont)
Alterations of the gut microbiota and mucosal barrier are linked with metabolic diseases. Our aim was to investigate the potential benefit of the potential probiotic Bifidobacterium animalis ssp. lactis 420 in reducing high-fat diet-induced body weight gain and diabetes in mice. In the obesity model, C57Bl/6J mice were fed a high-fat diet (60 energy %) for 12 weeks, and gavaged daily with B. lactis 420 (109 cfu) or vehicle. In the diabetes model, mice were fed a high-fat, ketogenic diet (72 ener...
52 Citations Source Cite
Published on Nov 1, 2014in Diabetes Research and Clinical Practice 2.55
D. Zhang1
Estimated H-index: 1
(Central South University),
Liwei Zhang2
Estimated H-index: 2
(Central South University)
+ 3 AuthorsY. Zeng1
Estimated H-index: 1
(Central South University)
Abstract Aims Studies suggest that type 2 diabetes mellitus is associated with increased gut permeability. Human zonulin is the only physiological mediator discovered to date that is known to regulate gut permeability reversibly by disassembling intestinal tight junctions. However, the relationship between zonulin and type 2 diabetes remains to be defined, and no Chinese population-based data were reported. The aim of this study was to investigate the association between serum zonulin levels and...
31 Citations Source Cite
Cited By28
Newest
Published on May 9, 2019in BioMed Research International 2.58
Bhagavathi Sundaram Sivamaruthi6
Estimated H-index: 6
(Chiang Mai University),
Periyanaina Kesika6
Estimated H-index: 6
(Chiang Mai University)
+ 1 AuthorsChaiyavat Chaiyasut14
Estimated H-index: 14
(Chiang Mai University)
Probiotics are now recognized for several health benefits and they have been recommended as a complementary therapeutic agent for metabolic disorders. Obesity is an altered health condition, which is a resultant of irregular energy intake and energy balance, changes in gut microbiota, and improper diet with the influence of genetic makeup and environmental factors. Several studies revealed the influence of probiotic supplementation on obesity-associated consequences in vitro, in vivo, and in hum...
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Published on May 1, 2019in Food Science and Nutrition
Daisuke Anzawa1
Estimated H-index: 1
(Ezaki Glico Co., Ltd.),
Takashi Mawatari4
Estimated H-index: 4
(Ezaki Glico Co., Ltd.)
+ 7 AuthorsTakashi Kuriki29
Estimated H-index: 29
(Ezaki Glico Co., Ltd.)
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Zhi-Bin Wang (Academy of Medical Sciences, United Kingdom), Shan-Shan Xin + 4 AuthorsXian-Dang Zhang (Academy of Medical Sciences, United Kingdom)
Background. The prevalence of overweight/obesity in adults is raised to 39%, which is nearly tripled more than 1975. The alteration of the gut microbiome has been widely accepted as one of the main causal factors. To find an effective strategy for the prevention and treatment of overweight/obesity, a systematic review and meta-analysis were designed. Methods. In this study, we systematically reviewed the article published from January 2008 to July 2018 and conducted a meta-analysis to examine th...
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Published on Apr 1, 2019in Molecular metabolism 6.29
Xinxin Ke (The Chinese University of Hong Kong), Alesia Walker10
Estimated H-index: 10
+ 8 AuthorsThomas Clavel6
Estimated H-index: 6
(Technische Universität München)
Abstract Objective The gut microbiota is an important influencing factor of metabolic health. Although dietary interventions with probiotics, prebiotics, and synbiotics can be effective means to regulate obesity and associated comorbidities, the underlying shifts in gut microbial communities, especially at the functional level, have not been characterized in great details. In this study, we sought to investigate the effects of synbiotics on the regulation of gut microbiota and the alleviation of...
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Published on Apr 1, 2019in Current Gastroenterology Reports
Maya Fayfman6
Estimated H-index: 6
(Emory University),
Kristen Flint (Emory University), Shanthi Srinivasan31
Estimated H-index: 31
(Emory University)
Purpose of Review The goal of the present review is to explore the relationship between dietary changes and alterations in gut microbiota that contribute to disorders of gut motility and obesity.
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Published on Mar 15, 2019in Nutrients 4.20
Tomás Cerdó4
Estimated H-index: 4
,
José Antonio García-Santos2
Estimated H-index: 2
+ 1 AuthorsCristina Campoy29
Estimated H-index: 29
Obesity is a global pandemic complex to treat due to its multifactorial pathogenesis—an unhealthy lifestyle, neuronal and hormonal mechanisms, and genetic and epigenetic factors are involved. Scientific evidence supports the idea that obesity and metabolic consequences are strongly related to changes in both the function and composition of gut microbiota, which exert an essential role in modulating energy metabolism. Modifications of gut microbiota composition have been associated with variation...
1 Citations Source Cite
Published on Mar 13, 2019in Beneficial Microbes 2.31
Ashley A. Hibberd6
Estimated H-index: 6
(DuPont),
C.C. Yde1
Estimated H-index: 1
(Aarhus University)
+ 6 AuthorsLotta Stenman5
Estimated H-index: 5
(DuPont)
The gut microbiota contributes to host energy metabolism, and altered gut microbiota has been associated with obesity-related metabolic disorders. We previously reported that a probiotic alone or t...
1 Citations Source Cite
Published on Mar 1, 2019in BMJ Open 2.41
Hana Koutnikova , Bernd Genser27
Estimated H-index: 27
(Heidelberg University)
+ 4 AuthorsKarine Clément68
Estimated H-index: 68
Objective To systematically review the effect of oral intake of bacterial probiotics on 15 variables related to obesity, diabetes and non-alcoholic fatty liver disease. Design Systematic review and meta-analysis. Data sources Medline, EMBASE and COCHRANE from 1990 to June 2018. Eligibility criteria Randomised controlled trials (≥14 days) excluding hypercholesterolaemia, alcoholic liver disease, polycystic ovary syndrome and children Results One hundred and five articles met inclusion criteria, r...
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