Match!

Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults—Randomized Controlled Trial

Published on Nov 1, 2016in EBioMedicine
· DOI :10.1016/j.ebiom.2016.10.036
Lotta Stenman5
Estimated H-index: 5
(DuPont),
Markus J. Lehtinen7
Estimated H-index: 7
(DuPont)
+ 12 AuthorsSampo J. Lahtinen28
Estimated H-index: 28
(DuPont)
Abstract
Abstract Background The gut microbiota is interlinked with obesity, but direct evidence of effects of its modulation on body fat mass is still scarce. We investigated the possible effects of Bifidobacterium animalis ssp. lactis 420 (B420) and the dietary fiber Litesse® Ultra polydextrose (LU) on body fat mass and other obesity-related parameters. Methods 225 healthy volunteers (healthy, BMI 28–34.9) were randomized into four groups (1:1:1:1), using a computer-generated sequence, for 6months of double-blind, parallel treatment: 1) Placebo, microcrystalline cellulose, 12g/d; 2) LU, 12g/d; 3) B420, 10 10 CFU/d in microcrystalline cellulose, 12g/d; 4) LU+B420, 12g+10 10 CFU/d. Body composition was monitored with dual-energy X-ray absorptiometry, and the primary outcome was relative change in body fat mass, comparing treatment groups to Placebo. Other outcomes included anthropometric measurements, food intake and blood and fecal biomarkers. The study was registered in Clinicaltrials.gov (NCT01978691). Findings There were marked differences in the results of the Intention-To-Treat (ITT; n =209) and Per Protocol (PP; n =134) study populations. The PP analysis included only those participants who completed the intervention with >80% product compliance and no antibiotic use. In addition, three participants were excluded from DXA analyses for PP due to a long delay between the end of intervention and the last DXA measurement. There were no significant differences between groups in body fat mass in the ITT population. However, LU+B420 and B420 seemed to improve weight management in the PP population. For relative change in body fat mass, LU+B420 showed a−4.5% (−1.4kg, P =0.02, N =37) difference to the Placebo group, whereas LU (+0.3%, P =1.00, N =35) and B420 (−3.0%, P =0.28, N =24) alone had no effect (overall ANOVA P =0.095, Placebo N =35). A post-hoc factorial analysis was significant for B420 (−4.0%, P =0.002 vs. Placebo). Changes in fat mass were most pronounced in the abdominal region, and were reflected by similar changes in waist circumference. B420 and LU+B420 also significantly reduced energy intake compared to Placebo. Changes in blood zonulin levels and hsCRP were associated with corresponding changes in trunk fat mass in the LU+B420 group and in the overall population. There were no differences between groups in the incidence of adverse events. Discussion This clinical trial demonstrates that a probiotic product with or without dietary fiber controls body fat mass. B420 and LU+B420 also reduced waist circumference and food intake, whereas LU alone had no effect on the measured outcomes.
  • References (49)
  • Citations (28)
References49
Newest
#1Lotta Stenman (DuPont)H-Index: 5
#2Aurélie Waget (French Institute of Health and Medical Research)H-Index: 25
Last.Sampo J. Lahtinen (DuPont)H-Index: 28
view all 7 authors...
#1K. A. Elisa Kallio (UH: University of Helsinki)H-Index: 4
#2Katja A. Hätönen (National Institute for Health and Welfare)H-Index: 7
Last.Pirkko J. Pussinen (UH: University of Helsinki)H-Index: 41
view all 6 authors...
#1Alvin Ibarra (DuPont)H-Index: 14
#2Nerys M. Astbury (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 12
Last.Kirsti Tiihonen (DuPont)H-Index: 21
view all 5 authors...
#1D. Zhang (CSU: Central South University)H-Index: 1
#2Liwei Zhang (CSU: Central South University)H-Index: 2
Last.Y. Zeng (CSU: Central South University)H-Index: 1
view all 6 authors...
Cited By28
Newest
#1Yan Guo ('SMMU': Second Military Medical University)H-Index: 4
#2Chao-Qian Liu ('SMMU': Second Military Medical University)H-Index: 3
Last.Dajin Zou ('SMMU': Second Military Medical University)H-Index: 11
view all 5 authors...
#1Anissa M. Armet (U of A: University of Alberta)H-Index: 1
#2Edward C. Deehan (U of A: University of Alberta)H-Index: 3
Last.Jens Walter (U of A: University of Alberta)H-Index: 38
view all 5 authors...
#1Bhagavathi Sundaram Sivamaruthi (CMU: Chiang Mai University)H-Index: 6
#2Periyanaina Kesika (CMU: Chiang Mai University)H-Index: 6
Last.Chaiyavat Chaiyasut (CMU: Chiang Mai University)H-Index: 14
view all 4 authors...
#1Maya Fayfman (Emory University)H-Index: 6
#2Kristen Flint (Emory University)
Last.Shanthi Srinivasan (Emory University)H-Index: 31
view all 3 authors...
View next paperRegulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial