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#1Lingman Ma (CPU: China Pharmaceutical University)H-Index: 3
#2Xinyue Ye (CPU: China Pharmaceutical University)H-Index: 1
Last. Changlin Zhou (CPU: China Pharmaceutical University)H-Index: 13
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ABSTRACT Background The antibiotic resistance and biofilm formation of pathogenic microbes exacerbate the difficulties of anti-infection therapy in the clinic. The structural modification of antimicrobial peptides (AMP) is an effective strategy to develop novel anti-infective agents. Method Seventeen amino acids (AA) in the longer chain of EeCentrocin 1 (from the edible sea-urchin Echinus esculentus) were truncated and underwent further modification. To produce lead peptides with low toxicity an...
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#1Maria Laggner (Medical University of Vienna)H-Index: 3
#2Dragan Copic (Medical University of Vienna)H-Index: 1
Last. Michael Mildner (Medical University of Vienna)H-Index: 33
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Abstract Background Since numerous pathological conditions are evoked by unwanted dendritic cell (DC) activity, therapeutic agents modulating DC functions are of great medical interest. In regenerative medicine, cellular secretomes have gained increasing attention and valuable immunomodulatory properties have been attributed to the secretome of γ-irradiated peripheral blood mononuclear cells (PBMCs). Potential effects of the PBMC secretome (PBMCsec) on key DC functions have not been elucidated s...
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#1Lynn Grignard (Lond: University of London)H-Index: 11
#2Debbie Nolder (Lond: University of London)H-Index: 13
Last. Susana Campino (Lond: University of London)H-Index: 31
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Abstract Background Many health facilities in malaria endemic countries are dependent on Rapid diagnostic tests (RDTs) for diagnosis and some National Health Service (NHS) hospitals without expert microscopists rely on them for diagnosis out of hours. The emergence of P. falciparum lacking the gene encoding histidine-rich protein 2 and 3 (HRP2 and HRP3) and escaping RDT detection threatens progress in malaria control and elimination. Currently, confirmation of RDT negative due to the deletion of...
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#1Che-Hong Chen (Stanford University)H-Index: 28
#2Julio Cesar Batista Ferreira (USP: University of São Paulo)H-Index: 27
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Abstract Background Aldehyde dehydrogenase 2 (ALDH2) catalyzes the detoxification of aliphatic aldehydes, including acetaldehyde. About 45% of Han Chinese (East Asians), accounting for 8% of humans, carry a single point mutation in ALDH2*2 (E504K) that leads to accumulation of toxic reactive aldehydes. Methods Sequencing of a small Mexican cohort and a search in the ExAC genomic database for additional ALDH2 variants common in various ethnic groups was set to identify missense variants. These we...
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#1Veronica L. Peterson (UCC: University College Cork)H-Index: 7
#2Jerry B. Richards (UB: University at Buffalo)H-Index: 16
Last. Thomaz F. S. Bastiaanssen (UCC: University College Cork)H-Index: 5
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Abstract Background Multiple factors contribute to the etiology of addiction, including genetics, sex, and a number of addiction-related behavioral traits. One behavioral trait where individuals assign incentive salience to food stimuli (“sign-trackers”, ST) are more impulsive compared to those that do not (“goal-trackers”, GT), as well as more sensitive to drugs and drug stimuli. Furthermore, this GT/ST phenotype predicts differences in other behavioral measures. Recent studies have implicated ...
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#1Krutika Kuppalli (Stanford University)
#2Angela L. Rasmussen (Columbia University)H-Index: 13
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#1Shuang Chen (Cedars-Sinai Medical Center)H-Index: 24
#2Timothy R. Crother (Cedars-Sinai Medical Center)H-Index: 22
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#1Michael G. Harrington (Huntington Medical Research Institutes)H-Index: 22
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#1Lixia Wang (Soochow University (Suzhou))H-Index: 9
#2Min Lin (WMU: Wenzhou Medical College)H-Index: 8
Last. Zhi-wei Wang (WMU: Wenzhou Medical College)
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Abstract Background Emerging evidence has demonstrated that SPOP functions as an oncoprotein in kidney cancer to promote tumorigenesis by ubiquitination-mediated degradation of multiple regulators of cellular proliferation and apoptosis. However, the detailed molecular mechanism underlying the oncogenic role of SPOP in kidney tumorigenesis remains elusive. Methods Multiple approaches such as Co-IP, Transfection, RT-PCR, Western blotting, and animal studies were utilized to explore the role of SP...
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#1Wei-wei Wang (Zhengzhou University)H-Index: 2
#2Zhihua Zhao (Zhengzhou University)H-Index: 3
Last. Xiang-Nan Li (Zhengzhou University)H-Index: 1
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