Evidence that COMT genotype and proline interact on negative-symptom outcomes in schizophrenia and bipolar disorder

Elevated peripheral proline is associated with psychiatric disorders, and there is evidence that proline is a neuromodulator. The proline dehydrogenase ( PRODH ) gene, which encodes the enzyme that catalyzes proline catabolism, maps to human chromosome 22q11.2, a region conferring risk of schizophrenia. In the Prodh -null mouse, an interaction between elevated peripheral proline and another 22q11.2 gene, catechol- O -methyltransferase ( COMT ),...