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Translational Psychiatry
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#1Anshua Ghosh ('KCL': King's College London)H-Index: 3
#2Keiko Mizuno ('KCL': King's College London)H-Index: 16
Last. K. Peter Giese ('KCL': King's College London)H-Index: 21
view all 8 authors...
Alzheimer’s disease (AD) is characterised by Aβ and tau pathology as well as synaptic degeneration, which correlates best with cognitive impairment. Previous work suggested that this pathological complexity may result from changes in mRNA translation. Here, we studied whether mRNA translation and its underlying signalling are altered in an early model of AD, and whether modelling this deficiency in mice causes pathological features with ageing. Using an unbiased screen, we show that exposure of ...
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#1Liang Shi (Georgia Regents University)
#2Clare M Bergson (Georgia Regents University)H-Index: 20
Neurodevelopmental psychiatric disorders including schizophrenia (Sz) and attention deficit hyperactivity disorder (ADHD) are chronic mental illnesses, which place costly and painful burdens on patients, their families and society. In recent years, the epidermal growth factor (EGF) family member Neuregulin 1 (NRG1) and one of its receptors, ErbB4, have received considerable attention due to their regulation of inhibitory local neural circuit mechanisms important for information processing, atten...
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#1Helen J. Chen (The Ohio State University Wexner Medical Center)H-Index: 1
#2A.M. Antonson (OSU: Ohio State University)
Last. Tamar L. GurH-Index: 15
view all 6 authors...
Prenatal stress (PNS) is associated with neuropsychiatric disorders in offspring, including anxiety, depression, and autism spectrum disorders. There is mounting evidence that these behavioral phenotypes have origins in utero. Maternal microbes, inflammation, and serotonergic dysfunction have been implicated as potential mediators of the behavioral consequences of PNS; whether and how these systems interact is unclear. Here, we examine the effects of PNS in utero using late-gestation maternal re...
1 CitationsSource
#1Philip A. Spechler (Yale University)
#3Jennifer L. Stewart (TU: University of Tulsa)H-Index: 24
Last. Martin P. Paulus (TU: University of Tulsa)H-Index: 81
view all 4 authors...
Individuals with mood/anxiety disorders may use cannabis for “self-medication,” i.e., to induce positive mood or attenuate aversive mood states. However, little neurobiological evidence supports such use. The goal of this investigation was to test the hypothesis that cannabis use attenuates striatal response to reward in those with mood/anxiety disorders. Reward-related processing was measured using a monetary incentive delay task under functional MRI. Individuals with any lifetime mood/anxiety ...
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#1Olga V. Sysoeva (UR: University of Rochester)H-Index: 1
#2Sophie Molholm (UR: University of Rochester)H-Index: 38
Last. John J. Foxe (UR: University of Rochester)H-Index: 76
view all 5 authors...
Due to severe motor impairments and the lack of expressive language abilities seen in most patients with Rett Syndrome (RTT), it has proven extremely difficult to obtain accurate measures of auditory processing capabilities in this population. Here, we examined early auditory cortical processing of pure tones and more complex phonemes in females with Rett Syndrome (RTT), by recording high-density auditory evoked potentials (AEP), which allow for objective evaluation of the timing and severity of...
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#1Shingo Kakeda (Hirosaki University)H-Index: 1
#2Keita WatanabeH-Index: 11
Last. Yukunori KorogiH-Index: 44
view all 9 authors...
In a previous mouse study, social defeat stress-induced microglial activation released tumor necrosis factor-α (TNF-α), leading to neuronal changes in the prefrontal cortex (PFC) and behavioral changes (anxiety). We aimed to investigate the relationship between gray-matter (GM) structural networks and serum TNF-α in patients with major depression disorder (MDD) using multivariate source-based morphometry (SBM). Forty-five first-episode and drug-naive MDD patients and 38 healthy subjects (HSs) we...
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#1Herman Wolosker (Technion – Israel Institute of Technology)H-Index: 38
#2Darrick T. Balu (Harvard University)H-Index: 19
Fear, anxiety, and trauma-related disorders, including post-traumatic stress disorder (PTSD), are quite common and debilitating, with an estimated lifetime prevalence of ~28% in Western populations. They are associated with excessive fear reactions, often including an inability to extinguish learned fear, increased avoidance behavior, as well as altered cognition and mood. There is an extensive literature demonstrating the importance of N-methyl-d-aspartate receptor (NMDAR) function in regulatin...
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#1Viviana Caputo (Sapienza University of Rome)H-Index: 19
#2Maria Giuseppina Pacilli (University of Perugia)H-Index: 12
Last. Beth Healey (ESA: European Space Agency)H-Index: 1
view all 14 authors...
Understanding individual capability to adjust to protracted confinement and isolation may inform adaptive plasticity and disease vulnerability/resilience, and may have long-term implications for operations requiring prolonged presence in distant and restricted environments. Individual coping depends on many different factors encompassing psychological dispositional traits, endocrine reactivity and their underlying molecular mechanisms (e.g. gene expression). A positive view of self and others (s...
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#1Jason J. Wang (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 41
#2Danyue Zhao (RU: Rutgers University)H-Index: 7
Last. James E. SimonH-Index: 43
view all 12 authors...
Major depressive disorder (MDD) is a leading cause of disability, and there is an urgent need for new therapeutics. Stress-mediated induction of pro-inflammation in the periphery contributes to depression-like behaviors both in humans and in experimental models. Inflammatory cytokine interleukin-6 (IL-6) has emerged as a potential therapeutic target. Our studies demonstrated that metabolism of flavanol rich cocoa preparation (FRP) led to the accumulation of select phenolic acids that may contrib...
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#1Suhua Chang (PKU: Peking University)H-Index: 1
#2Li Yang (PKU: Peking University)H-Index: 19
Last. Stephen V. Faraone (State University of New York Upstate Medical University)H-Index: 164
view all 4 authors...
Many psychiatric disorders are associated with impaired executive functioning (EF). The associated EF component varies by psychiatric disorders, and this variation might be due to genetic liability. We explored the genetic association between five psychiatric disorders and EF in clinically-recruited attention deficit hyperactivity disorder (ADHD) children using polygenic risk score (PRS) methodology. Genome-wide association study (GWAS) summary data for ADHD, major depressive disorder (MDD), sch...
1 CitationsSource
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Top fields of study
Psychiatry
Developmental psychology
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