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Translational Psychiatry
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5.18
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1809
Papers 1871
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#1Koen Schruers (UM: Maastricht University)H-Index: 30
#2Samantha Baldi (UM: Maastricht University)
Last.Wolfgang Viechtbauer (UM: Maastricht University)H-Index: 37
view all 9 authors...
Non-intervention-related effects have long been recognized in an array of medical interventions, to which surgical procedures like deep-brain stimulation are no exception. While the existence of placebo and micro-lesion effects has been convincingly demonstrated in DBS for major depression and Parkinson’s disease, systematic investigations for obsessive-compulsive disorder (OCD) are currently lacking. We therefore undertook an individual patient data meta-analysis with the aim of quantifying the...
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#1Obelia Haida (University of Poitiers)H-Index: 2
#2Tareq Al Sagheer (University of Poitiers)H-Index: 2
Last.Mohamed Jaber (University of Poitiers)H-Index: 26
view all 8 authors...
Infections during gestation and the consequent maternal immune activation (MIA) increase the risk of developing neuropsychiatric disorders in infants and throughout life, including autism spectrum disorders (ASD). ASD is a neurodevelopmental disorder that affects three times more males than females and is mainly characterized by deficits in social communication and restricted interests. Consistent findings also indicate that ASD patients suffer from movement disorders, although these symptoms ar...
2 CitationsSource
#1Pierluca Coiro (Medical University of Vienna)H-Index: 1
#2Daniela D. Pollak (Medical University of Vienna)H-Index: 18
Recent and rapidly developing movements relating to the increasing awareness and reports of gender bias, discrimination, and abuse have reached the academic environments. The consideration that negative attitudes toward women and abuse of power creates a hostile environment for female scientists, facilitating sexual harassment and driving women out of science, can be easily related to. Rationally inaccessible gender biases are not only evident at the level of the researchers, but are also parall...
6 CitationsSource
#1Sudeepa Bhattacharyya (University of Arkansas for Medical Sciences)H-Index: 14
#2Ahmed T. Ahmed (Mayo Clinic)H-Index: 11
Last.Rima Kaddurah-Daouk (Duke University)H-Index: 43
view all 16 authors...
Metabolomics provides valuable tools for the study of drug effects, unraveling the mechanism of action and variation in response due to treatment. In this study we used electrochemistry-based targeted metabolomics to gain insights into the mechanisms of action of escitalopram/citalopram focusing on a set of 31 metabolites from neurotransmitter-related pathways. Overall, 290 unipolar patients with major depressive disorder were profiled at baseline, after 4 and 8 weeks of drug treatment. The 17-i...
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#1Susanne Bejerot (Örebro University)H-Index: 24
#2Albin Klang (Örebro University)
Last.Eva Hesselmark (KI: Karolinska Institutet)H-Index: 5
view all 3 authors...
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#1Jonathan D. Cooper (University of Cambridge)H-Index: 67
#2Sung Yeon Sarah Han (University of Cambridge)H-Index: 2
Last.Sabine Bahn (University of Cambridge)H-Index: 53
view all 8 authors...
textabstractIn the present study, to improve the predictive performance of a model and its reproducibility when applied to an independent data set, we investigated the use of multimodel inference to predict the probability of having a complex psychiatric disorder. We formed training and test sets using proteomic data (147 peptides from 77 proteins) from twoindependent collections of first-onset drug-naive schizophrenia patients and controls. A set of prediction models was produced by applying la...
2 CitationsSource
#1Maarten J. A. Van Den Bossche (Katholieke Universiteit Leuven)
#2Louise Emsell (Katholieke Universiteit Leuven)H-Index: 18
Last.Mathieu Vandenbulcke (Katholieke Universiteit Leuven)H-Index: 29
view all 10 authors...
Several studies have shown that electroconvulsive therapy (ECT) results in increased hippocampal volume. It is likely that a multitude of mechanisms including neurogenesis, gliogenesis, synaptogenesis, angiogenesis, and vasculogenesis contribute to this volume increase. Neurotrophins, like vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) seem to play a crucial mediating role in several of these mechanisms. We hypothesized that two regulatory SNPs in the VEGF...
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#1Karen Sugden (Duke University)H-Index: 26
#2Eilis Hannon (University of Exeter)H-Index: 20
Last.Avshalom CaspiH-Index: 150
view all 16 authors...
Large-scale epigenome-wide association meta-analyses have identified multiple ‘signatures’’ of smoking. Drawing on these findings, we describe the construction of a polyepigenetic DNA methylation score that indexes smoking behavior and that can be utilized for multiple purposes in population health research. To validate the score, we use data from two birth cohort studies: The Dunedin Longitudinal Study, followed to age-38 years, and the Environmental Risk Study, followed to age-18 years. Longit...
6 CitationsSource
#1Thomas H. McCoy (Harvard University)H-Index: 15
#2Amelia M. Pellegrini (Harvard University)H-Index: 3
Last.Roy H. Perlis (Harvard University)H-Index: 68
view all 3 authors...
While nearly all common genomic variants associated with schizophrenia have no known function, one corresponds to a missense variant associated with change in efficiency of a metal ion transporter, ZIP8, coded by SLC39A8. This variant has been linked to a range of phenotypes and is believed to be under recent selection pressure, but its impact on health is poorly understood. We sought to understand phenotypic implications of this variant in a large genomic biobank using an unbiased phenome-wide ...
2 CitationsSource
#1Janine Diehl-Schmid (TUM: Technische Universität München)H-Index: 27
#2Abigail Licata (TUM: Technische Universität München)H-Index: 1
Last.Timo Grimmer (TUM: Technische Universität München)H-Index: 31
view all 25 authors...
C9ORF72 mutations are the most common cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). MRI studies have investigated structural changes in C9ORF72-associated FTLD (C9FTLD) and provided first insights about a prominent involvement of the thalamus and the cerebellum. Our multicenter, 18F-fluorodeoxyglucose positron-emission tomography study of 22 mutation carriers with FTLD, 22 matched non-carriers with FTLD, and 23 cognitively healthy controls pr...
1 CitationsSource
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Top fields of study
Psychiatry
Developmental psychology
Psychology
Neuroscience
Schizophrenia