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Blunted Neural Response to Rewards as a Prospective Predictor of the Development of Depression in Adolescent Girls

Published on Dec 1, 2016in American Journal of Psychiatry13.65
· DOI :10.1176/appi.ajp.2016.15121524
Brady D. Nelson17
Estimated H-index: 17
,
Greg Perlman12
Estimated H-index: 12
+ 2 AuthorsGreg Hajcak64
Estimated H-index: 64
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Abstract
Objective:A blunted neural response to rewards has recently emerged as a potential mechanistic biomarker of adolescent depression. The reward positivity, an event-related potential elicited by feedback indicating monetary gain relative to loss, has been associated with risk for depression. The authors examined whether the reward positivity prospectively predicted the development of depression 18 months later in a large community sample of adolescent girls.Method:The sample included 444 girls 13.5–15.5 years old with no lifetime history of a depressive disorder, along with a biological parent for each girl. At baseline, the adolescents’ reward positivity was measured using a monetary guessing task, their current depressive symptoms were assessed using a self-report questionnaire, and the adolescents’ and parents’ lifetime psychiatric histories were evaluated with diagnostic interviews. The same interview and questionnaire were administered to the adolescents again approximately 18 months later.Results:A bl...
  • References (21)
  • Citations (45)
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References21
Newest
Published on Dec 1, 2015in American Journal of Psychiatry13.65
Argyris Stringaris31
Estimated H-index: 31
,
Pablo Vidal-Ribas Belil1
Estimated H-index: 1
+ 34 AuthorsMaren Struve17
Estimated H-index: 17
Objective:The authors examined whether alterations in the brain’s reward network operate as a mechanism across the spectrum of risk for depression. They then tested whether these alterations are specific to anhedonia as compared with low mood and whether they are predictive of depressive outcomes.Method:Functional MRI was used to collect blood-oxygen-level-dependent (BOLD) responses to anticipation of reward in the monetary incentive task in 1,576 adolescents in a community-based sample. Adolesc...
Published on Mar 28, 2014in Annual Review of Clinical Psychology14.10
Diego A. Pizzagalli57
Estimated H-index: 57
(Harvard University)
Depression is a significant public health problem, but its etiology and pathophysiology remain poorly understood. Such incomplete understanding likely arises from the fact that depression encompasses a heterogeneous set of disorders. To overcome these limitations, renewed interest in intermediate phenotypes (endophenotypes) has resurfaced, and anhedonia has emerged as one of the most promising endophenotypes of depression. Here, a heuristic model is presented postulating that anhedonia arises fr...
Published on Apr 1, 2013in Neurobiology of Disease5.16
Judith K. Morgan11
Estimated H-index: 11
(University of Pittsburgh),
Thomas M. Olino31
Estimated H-index: 31
(University of Pittsburgh)
+ 2 AuthorsErika E. Forbes42
Estimated H-index: 42
(University of Pittsburgh)
Abstract Adolescence is a developmental period characterized by significant increases in the onset of depression, but also by increases in depressive symptoms, even among psychiatrically healthy youth. Disrupted reward function has been postulated as a critical factor in the development of depression, but it is still unclear which adolescents are particularly at risk for rising depressive symptoms. We provide a conceptual stance on gender, pubertal development, and reward type as potential moder...
Published on May 1, 2012in Journal of Psychopharmacology4.22
Meline Stoy15
Estimated H-index: 15
(Charité),
Florian Schlagenhauf26
Estimated H-index: 26
(Charité)
+ 11 AuthorsBrian Knutson B59
Estimated H-index: 59
(Stanford University)
Major Depressive Disorder (MDD) involves deficits in the reward system. While neuroimaging studies have focused on affective stimulus processing, few investigations have directly addressed deficits in the anticipation of incentives. We examined neural responses during gain and loss anticipation in patients with MDD before and after treatment with a selective serotonin reuptake inhibitor (SSRI). Fifteen adults with MDD and 15 healthy participants, matched for age, verbal IQ and smoking habits, we...
Published on Jan 1, 2012in Biological Psychology2.63
Jennifer N. Bress9
Estimated H-index: 9
(SBU: Stony Brook University),
Ezra Smith5
Estimated H-index: 5
(SBU: Stony Brook University)
+ 2 AuthorsGreg Hajcak64
Estimated H-index: 64
(SBU: Stony Brook University)
Depression is a major public health concern, and the period from late childhood through early adolescence is a critical time in the development of depressive symptoms. In adults, depression and depressive symptoms are associated with a reduction in the feedback negativity (FN), an ERP component elicited by feedback indicating rewards versus losses. The current study sought to extend these findings to a sample of 64 children aged 8 to 13, and to examine developmental differences in the FN. Consis...
Published on Oct 1, 2011in Journal of Abnormal Child Psychology3.41
Dan Foti25
Estimated H-index: 25
(SBU: Stony Brook University),
Roman Kotov36
Estimated H-index: 36
(SBU: Stony Brook University)
+ 1 AuthorsGreg Hajcak64
Estimated H-index: 64
(SBU: Stony Brook University)
Major depressive disorder aggregates within families, although the mechanisms of transfer across generations are not well understood. In light of converging biological and behavioral evidence that depressive symptoms are associated with impaired reward processing, we examined whether adolescent girls with a parental history of depression would also exhibit abnormal reward sensitivity. We performed a negative mood induction and then recorded the feedback negativity, a neural index of reward proce...
Published on Mar 1, 2011in Clinical Child and Family Psychology Review3.56
Sherryl H. Goodman43
Estimated H-index: 43
(Emory University),
Matthew H. Rouse4
Estimated H-index: 4
(Emory University)
+ 3 AuthorsDevin Heyward1
Estimated H-index: 1
(Hunter College)
Although the association between maternal depression and adverse child outcomes is well established, the strength of the association, the breadth or specificity of the outcomes, and the role of moderators are not known. This information is essential to inform not only models of risk but also the design of preventive interventions by helping to identify subgroups at greater risk than others and to elucidate potential mechanisms as targets of interventions. A meta-analysis of 193 studies was condu...
Kathleen R. Merikangas102
Estimated H-index: 102
,
Jian-Ping He20
Estimated H-index: 20
+ 6 AuthorsJoel Swendsen41
Estimated H-index: 41
(CNRS: Centre national de la recherche scientifique)
Objective To present estimates of the lifetime prevalence of DSM-IV mental disorders with and without severe impairment, their comorbidity across broad classes of disorder, and their sociodemographic correlates. Method The National Comorbidity Survey–Adolescent Supplement NCS-A is a nationally representative face-to-face survey of 10,123 adolescents aged 13 to 18 years in the continental United States. DSM-IV mental disorders were assessed using a modified version of the fully structured World H...
Published on Apr 1, 2010in Archives of General Psychiatry
Ian H. Gotlib97
Estimated H-index: 97
(Stanford University),
J. Paul Hamilton19
Estimated H-index: 19
(Stanford University)
+ 3 AuthorsJutta Joormann52
Estimated H-index: 52
Context Deficits in reward processing and their neural correlates have been associated with major depression. However, it is unclear if these deficits precede the onset of depression or are a consequence of this disorder. Objective To determine whether anomalous neural processing of reward characterizes children at familial risk for depression in the absence of a personal history of diagnosable disorder. Design Comparison of neural activity among children at low and high risk for depression as t...
Published on Sep 1, 2009in Journal of Child Psychology and Psychiatry6.13
Kate Keenan48
Estimated H-index: 48
(U of C: University of Chicago),
Xin Feng13
Estimated H-index: 13
(University of Pittsburgh)
+ 1 AuthorsSusan Klostermann3
Estimated H-index: 3
(University of Pittsburgh)
Background: The high comorbidity between depressive and anxiety disorders, especially among females, has called into question the independence of these two symptom groups. It is possible that childhood anxiety typically precedes depression in girls. Comparing of the predictive utility of symptoms of anxiety with the predictive utility of symptoms of depression from early childhood to early adolescence is needed to test this hypothesis. Methods: Data from a population-based sample of 2,451 girls ...
Cited By45
Newest
Published on 2019in Developmental Cognitive Neuroscience4.92
Yara Toenders (University of Melbourne), Laura S. van Velzen (University of Melbourne)+ 3 AuthorsLianne Schmaal21
Estimated H-index: 21
(University of Melbourne)
Abstract Major depressive disorder (MDD) often emerges during adolescence with detrimental effects on development as well as lifetime consequences. Identifying neurobiological markers that are associated with the onset or course of this disorder in childhood and adolescence is important for early recognition and intervention and, potentially, for the prevention of illness onset. In this systematic review, 68 longitudinal neuroimaging studies, from 34 unique samples, that examined the association...
Published on Apr 24, 2019in Clinical psychological science
Keanan J. Joyner3
Estimated H-index: 3
(FSU: Florida State University),
Colin B. Bowyer (FSU: Florida State University)+ 6 AuthorsChristopher J. Patrick67
Estimated H-index: 67
(FSU: Florida State University)
Reward-deficit models of addiction posit weaknesses in reward sensitivity to be promotive of substance dependence, whereas the externalizing spectrum model views substance problems as arising in large part from a general disinhibitory liability. In the current study we sought to integrate these perspectives by testing for separate and interactive associations of disinhibition and reward dysfunction with interview-assessed substance use disorders (SUDs). Community and college adults (N = 199) com...
Published on Jul 9, 2019in Clinical psychological science
Aliona Tsypes7
Estimated H-index: 7
(Binghamton University),
Max Owens8
Estimated H-index: 8
(USF: University of South Florida),
Brandon E. Gibb35
Estimated H-index: 35
(Binghamton University)
Published on 2019in Frontiers in Behavioral Neuroscience2.62
Jingwen Jin (SBU: Stony Brook University), Amri Sabharwal2
Estimated H-index: 2
(SBU: Stony Brook University)
+ 2 AuthorsBrady D. Nelson17
Estimated H-index: 17
(SBU: Stony Brook University)
Social feedback is highly salient and particularly relevant when investigating the pathophysiology of depression and social anxiety. A bourgeoning body of research has demonstrated an association between reward-related delta activity and psychopathology. However, a critical limitation is that these findings are derived from neural responses to monetary feedback, and time-frequency representation of social feedback remains unexplored. In addition, no study has isolated the differential/unique ass...
Kreshnik Burani (FSU: Florida State University), Julia Klawohn7
Estimated H-index: 7
(FSU: Florida State University)
+ 3 AuthorsGreg Hajcak64
Estimated H-index: 64
(FSU: Florida State University)
Published on Jul 1, 2019in Biological Psychology2.63
Aislinn Sandre1
Estimated H-index: 1
(McGill University),
Rosemary C. Bagot3
Estimated H-index: 3
(McGill University),
Anna Weinberg26
Estimated H-index: 26
(McGill University)
Abstract Individual differences in neural response to appetitive and aversive stimuli may confer vulnerability to stress-related psychopathology, including depression and anxiety. However, the specificity of this association with symptoms of depression and anxiety within the context of real-world stress is not well understood. The present study examined whether neural responses to appetitive and aversive images, measured by the late positive potential (LPP), prospectively predict symptoms of dep...
Published on Jul 1, 2019in Personality and Individual Differences2.00
Aliona Tsypes7
Estimated H-index: 7
(Binghamton University),
Douglas Jozef Angus5
Estimated H-index: 5
(USYD: University of Sydney)
+ 2 AuthorsEddie Harmon-Jones63
Estimated H-index: 63
(UNSW: University of New South Wales)
Abstract Although research shows that affect and motivation-related variables influence the amplitude of the Reward Positivity (RewP) event-related potential (ERP), motivational direction (approach versus avoidance) and affective valence (positive versus negative) have been confounded. As a negatively valenced yet approach motivation-related emotion, anger can be used to tease apart motivational direction versus affective valence contributions to the RewP amplitude. The present study examined th...
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