Blunted Neural Response to Rewards as a Prospective Predictor of the Development of Depression in Adolescent Girls

Published on Dec 1, 2016in American Journal of Psychiatry13.655
· DOI :10.1176/appi.ajp.2016.15121524
Brady D. Nelson19
Estimated H-index: 19
Greg Perlman13
Estimated H-index: 13
+ 2 AuthorsGreg Hajcak66
Estimated H-index: 66
Objective:A blunted neural response to rewards has recently emerged as a potential mechanistic biomarker of adolescent depression. The reward positivity, an event-related potential elicited by feedback indicating monetary gain relative to loss, has been associated with risk for depression. The authors examined whether the reward positivity prospectively predicted the development of depression 18 months later in a large community sample of adolescent girls.Method:The sample included 444 girls 13.5–15.5 years old with no lifetime history of a depressive disorder, along with a biological parent for each girl. At baseline, the adolescents’ reward positivity was measured using a monetary guessing task, their current depressive symptoms were assessed using a self-report questionnaire, and the adolescents’ and parents’ lifetime psychiatric histories were evaluated with diagnostic interviews. The same interview and questionnaire were administered to the adolescents again approximately 18 months later.Results:A bl...
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