Abstract Background Research on a putative link between apolipoprotein-e4 allele (APOE-e4) and schizophrenia has been inconclusive. However, prior studies have not investigated the association between APOE-e4 and symptom trajectories, nor has the existing literature taken into account the potentially moderating effect of age in genetic association studies. Methods The association between APOE-e4 and four symptom dimensions was investigated in a longitudinal study of 116 individuals with schizoph...
Abstract Understanding whether and how the schizophrenia polygenic risk score (SZ PRS) predicts course of illness could improve diagnostics and prognostication in psychotic disorders. We tested whether the SZ PRS predicts symptoms, cognition, illness severity, and diagnostic changes over the 20 years following first admission. The Suffolk County Mental Health Project is an inception cohort study of first-admission patients with psychosis. Patients were assessed six times over 20 years, and 249 p...