Coagulation factor VII and malignant progression of hepatocellular carcinoma

In this invited News and Commentary article, we discuss our new paper ‘Factor VII promotes hepatocellular carcinoma progression through ERK–TSC signaling' in Cell Death Discovery (ref. 8). Coagulation factor VII (FVII) is engaged in the initiation of the extrinsic coagulation pathway by binding to tissue factor (TF), and both factors have been considered as alternative therapeutic targets in hemostatic disorders and specific types of...