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Cell Death and Disease
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Papers 5417
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#1Qian Hao (Fudan University)H-Index: 1
#2Jieqiong Wang (Fudan University)
Last. Xiang ZhouH-Index: 32
view all 7 authors...
The Shwachman-Bodian Diamond syndrome (SBDS)-associated gene, SBDS, is involved in rRNA synthesis and ribosome maturation, but the role of SBDS in cancer is largely elusive. In this study, we found that SBDS is often overexpressed or amplified in human cancers, and high level of endogenous SBDS is significantly associated with unfavorable prognosis. Conversely, knockdown of SBDS leads to p53 stabilization and activation through the ribosomal stress-RPL5/RPL11-MDM2 pathway, resulting in the repre...
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#1Xindi Dang (East Tennessee State University James H. Quillen College of Medicine)H-Index: 3
#2Stella C. Ogbu (East Tennessee State University James H. Quillen College of Medicine)
Last. Xiao Y. Wu (East Tennessee State University James H. Quillen College of Medicine)H-Index: 16
view all 19 authors...
T cells play a critical role in controlling viral infection; however, the mechanisms regulating their responses remain incompletely understood. Here, we investigated the role of topoisomerase IIA (Top2α, an enzyme that is essential in resolving entangled DNA strands during replication) in telomeric DNA damage and T cell dysfunction during viral infection. We demonstrated that T cells derived from patients with chronic viral (HBV, HCV, and HIV) infection had lower Top2α protein levels and enzymat...
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#1Yu-Chan Chang (AS: Academia Sinica)H-Index: 3
#2Yi-Fang YangH-Index: 1
Last. Michael Hsiao (AS: Academia Sinica)H-Index: 42
view all 8 authors...
Drug resistance remains a serious issue of clinical importance and is a consequence of cancer stemness. In this study, we showed that the level of Aldolase A (ALDOA) expression is significantly associated with the IC50 value of chemotherapy drugs in lung cancer. Our data revealed that ALDOA overexpression resulted in a significant increase of lung tumor spheres. The use of ingenuity pathway analysis (IPA) resulted in the identification of POU5F1 (Oct4) as the leading transcription factor of ALDO...
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#2Ying-Juan Li (SEU: Southeast University)H-Index: 1
Last. Yun-Feng RuiH-Index: 23
view all 7 authors...
The link between tendon stem/progenitor cells (TSPCs) senescence and tendon aging has been well recognized. However, the cellular and molecular mechanisms of TSPCs senescence are still not fully understood. In present study, we investigated the role of Aquaporin 1 (AQP1) in TSPCs senescence. We showed that AQP1 expression declines with age during tendon aging. In aged TSPCs, overexpression of AQP1 significantly attenuated TSPCs senescence. In addition, AQP1 overexpression also restored the age-r...
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#1Delphine Hoorelbeke (UGent: Ghent University)H-Index: 2
#2Elke Decrock (UGent: Ghent University)H-Index: 30
Last. Geert Bultynck (Katholieke Universiteit Leuven)H-Index: 50
view all 11 authors...
Radiotherapeutic treatment consists of targeted application of radiation beams to a tumor but exposure of surrounding healthy tissue is inevitable. In the brain, ionizing radiation induces breakdown of the blood–brain barrier by effects on brain microvascular endothelial cells. Damage from directly irradiated cells can be transferred to surrounding non-exposed bystander cells, known as the radiation-induced bystander effect. We investigated involvement of connexin channels and paracrine signalin...
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#1Isabel Weigand (University of Würzburg)H-Index: 7
#2Jochen Schreiner (University of Würzburg)
Last. José Pedro Friedmann Angeli (University of Würzburg)H-Index: 5
view all 14 authors...
Conditions of impaired adrenal function and tissue destruction, such as in Addison’s disease, and treatment resistance of adrenocortical carcinoma (ACC) necessitate improved understanding of the pathophysiology of adrenal cell death. Due to relevant oxidative processes in the adrenal cortex, our study investigated the role of ferroptosis, an iron-dependent cell death mechanism and found high adrenocortical expression of glutathione peroxidase 4 (GPX4) and long-chain-fatty-acid CoA ligase 4 (ACSL...
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#1Hui Kong (Third Military Medical University)H-Index: 3
#2Nan You (Third Military Medical University)H-Index: 1
Last. Zhuo Zhao (Third Military Medical University)H-Index: 7
view all 14 authors...
Adrenomedullin (ADM) is a multifunctional peptide that is expressed by many surface epithelial cells, but its relevance to Helicobacter pylori (H. pylori)-induced gastritis is unknown. Here, we found that gastric ADM expression was elevated in gastric mucosa of H. pylori-infected patients and mice. In H. pylori-infected human gastric mucosa, ADM expression was positively correlated with the degree of gastritis; accordingly, blockade of ADM resulted in decreased inflammation within the gastric mu...
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#1Hao Chen (Academy of Medical Sciences, United Kingdom)
#2Haifeng Zhang (SYSU: Sun Yat-sen University)
Last. Chen Zhang (Academy of Medical Sciences, United Kingdom)
view all 12 authors...
Treatment options for necrotizing enterocolitis (NEC) remain inadequate. Here we examined if and how prolyl hydroxylase 2 (PHD2) silencing enhances the paracrine effects of bone-marrow-derived mesenchymal stem cells (BM-MSCs) on NEC. In this study, BM-MSCs were transduced with lentiviruses containing GFP (GFP-MSC) or shPHD2-GFP constructs (PHDMSC), followed by intraperitoneal injection of the PHDMSC-conditioned medium (PHDMSC-CM) or the GFP-MSC-conditioned medium (MSC-CM) into a rat pup model of...
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#1Jie Ye (UM: University of Macau)
#2Anpei Huang (SYSU: Sun Yat-sen University)
Last. Chu-Xia Deng (UM: University of Macau)H-Index: 111
view all 15 authors...
Pancreatic ductal adenocarcinoma (PDAC) is associated with metaplastic changes in the pancreas but the transcriptional program underlying these changes is incompletely understood. The zinc finger transcription factor, PRDM3, is lowly expressed in normal pancreatic acini and its expression increases during tumorigenesis. Although PRDM3 promotes proliferation and migration of PDAC cell lines, the role of PRDM3 during tumor initiation from pancreatic acinar cells in vivo is unclear. In this study, ...
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#1Francine Ke (University of Melbourne)H-Index: 8
#2Graeme I. Lancaster (Monash University)H-Index: 28
Last. Andreas Strasser (University of Melbourne)H-Index: 110
view all 5 authors...
The intrinsic apoptotic pathway is controlled by the BCL-2 family of proteins, which exhibit either a pro-death or pro-survival function. Gene knockout studies revealed that different pro-survival BCL-2 proteins are critical for the survival of distinct cell types, although overlapping functions amongst such proteins have also been identified. In the process of studying mice lacking single alleles of Mcl-1 (Mcl-1+/−), Bcl-2 (Bcl-2+/−), or both in combination (Mcl-1+/−Bcl-2+/−), we observed that ...
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Top fields of study
Molecular biology
Apoptosis
Programmed cell death
Biology
Cell biology