Brain MRI abnormalities in schizophrenia: same genes or same environment?

Structural brain volume abnormalities are among the most extensively studied endophenotypes in schizophrenia. Bivariate genetic model fitting (adjusted to account for selection) was used to quantify the genetic relationship between schizophrenia and brain volumes and to estimate the heritability of these volumes.We demonstrated by simulation that the adjusted genetic model produced unbiased estimates for endophenotype heritability and the...