Cognitive impairment in the preclinical stage of dementia in FTD-3CHMP2Bmutation carriers: a longitudinal prospective study

A longitudinal study spanning over 8 years and including 17 asymptomatic individuals with CHMP2B mutations was conducted to assess the earliest neuropsychological changes in autosomal dominant neurodegenerative disease frontotemporal dementia (FTD) linked to chromosome 3 (FTD-3). Subjects were assessed with neuropsychological tests in 2002, 2005 and 2010.Cross-sectional analyses showed that the mutation carriers scored lower on tests of...