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Journal of Neurology, Neurosurgery, and Psychiatry
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25577
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Impulsive compulsive behaviours (ICBs) such as dopamine dysregulation syndrome (DDS), pathological gambling, compulsive sexual behaviour, punding, compulsive shopping and binge eating are recognised complications of dopaminergic treatment that affect at least one in seven patients with Parkinson’s disease (PD).1 Only a few studies provide long-term data on ICBs although any firm conclusions are limited by restricted follow-up periods. We present long-term longitudinal data on 46 PD patients with...
Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer’s disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly understood. For example, diffuse axonal injury is implicated in disrupting microtubule function, providing the potential context for pathologies of tau and amyloid to develop. The neuropathology of post-traumatic dementias is increasingly well characterised, with recent work focusing on chronic traumatic encephalopathy (CT...
#1Matthew J. Barrett (UVA: University of Virginia)H-Index: 6
#2Scott A. Sperling (UVA: University of Virginia)H-Index: 5
Last.T. Jason Druzgal (UVA: University of Virginia)H-Index: 11
view all 8 authors...
Objective A major contributor to dementia in Parkinson disease (PD) is degeneration of the cholinergic basal forebrain. This study determined whether cholinergic nucleus 4 (Ch4) density is associated with cognition in early and more advanced PD. Methods We analysed brain MRIs and neuropsychological test scores for 228 newly diagnosed PD participants from the Parkinson’s Progression Markers Initiative (PPMI), 101 healthy controls from the PPMI and 125 more advanced PD patients from a local retros...
#1Laura McWhirter (Edin.: University of Edinburgh)H-Index: 4
#2Laura McWhirter (Edin.: University of Edinburgh)
Last.Jennifer Stone (Edin.: University of Edinburgh)H-Index: 58
view all 7 authors...
Objective Foreign accent syndrome (FAS) is widely understood as an unusual consequence of structural neurological damage, but may sometimes represent a functional neurological disorder. This observational study aimed to assess the prevalence and utility of positive features of functional FAS in a large group of individuals reporting FAS. Methods Participants self-reporting FAS recruited from informal unmoderated online support forums and via professional networks completed an online survey. Spee...
#1Alexander Thompson (University of Oxford)H-Index: 6
#2Elizabeth Gray (University of Oxford)H-Index: 9
Last.Martin Turner (University of Oxford)H-Index: 78
view all 6 authors...
Objective To evaluate the classifier performance, clinical and biochemical correlations of cerebrospinal fluid (CSF) levels of the chitinase proteins Chitotriosidase-1 (CHIT1), Chitinase-3-like protein 1 (CHI3L1) and Chitinase-3-like protein 2 (CHI3L2) in amyotrophic lateral sclerosis (ALS). Methods CSF levels of CHIT1, CHI3L1, CHI3L2, phosphorylated neurofilament heavy chain (pNFH) and C-reactive protein were measured by ELISA in a longitudinal cohort of patients with ALS (n=82), primary latera...
Multiple sclerosis (MS) is a complex disease characterised by a multifactorial aetiology. Being a woman is the strongest risk factor for MS, by virtue of the sex alone. The existence of a gender bias is well known, since MS occurs more frequently in women than in men.1 2 Moreover, this predilection has increased almost worldwide, over the last few decades, and is the highest in Western countries situated in northern latitudes. Apart from the prominent role of sex hormones, recent modifications i...
Background Multimodal MRI-based classification may aid early frontotemporal dementia (FTD) diagnosis. Recently, presymptomatic FTD mutation carriers, who have a high risk of developing FTD, were separated beyond chance level from controls using MRI-based classification. However, it is currently unknown how these scores from classification models progress as mutation carriers approach symptom onset. In this longitudinal study, we investigated multimodal MRI-based classification scores between pre...
#1Elodie Hainque (French Institute of Health and Medical Research)H-Index: 2
#2Elodie Hainque (French Institute of Health and Medical Research)
Last.Florence HabarouH-Index: 10
view all 11 authors...
Glucose transporter type 1 deficiency syndrome (GLUT1-DS) is caused by heterozygous mutations in the SLC2A1 gene. Glucose transport is impaired across the blood–brain barrier and into astrocytes. This eventually results in cerebral energy deficiency.1 Typically, GLUT1-DS is associated with developmental delay, permanent motor disorders and paroxysmal manifestations including epileptic and non-epileptic paroxysmal episodes.1 2 The phenotypic spectrum is however much wider: exercise-induced paroxy...
#1Océane Landon-Cardinal (University of Paris)H-Index: 2
#2L. Gallay (Lyon College)
Last.T. StojkovicH-Index: 41
view all 26 authors...
Myalgia or muscle weakness is frequently observed during HIV infection (1), and 15% of HIV patients may have an increased serum creatine kinase (CK) level.1 Case reports or case series have suggested that HIV-associated myopathies represent a large spectrum of disease.2 To date, data on muscle involvement during HIV infection remain sparse and we aimed to describe the clinical characteristics and evolution of biopsy-proven HIV-associated myopathies. All HIV-positive patients who had a muscle bio...
#1Yasmine E. M. Dreissen (UvA: University of Amsterdam)H-Index: 5
#2Joke M. Dijk (UvA: University of Amsterdam)H-Index: 5
Last.J. D. Speelman (UvA: University of Amsterdam)H-Index: 48
view all 14 authors...
Objective To study the effect of botulinum neurotoxin (BoNT) treatment in jerky and tremulous functional movement disorders (FMD). Methods Patients with invalidating, chronic (>1 year) symptoms were randomly assigned to two subsequent treatments with BoNT or placebo every 3 months with stratification according to symptom localisation. Improvement on the dichotomised Clinical Global Impression-Improvement scale (CGI-I) (improvement vs no change or worsening) at 4 months, assessed by investigators...
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