Journal of Neurology, Neurosurgery, and Psychiatry
Papers 25646
1 page of 2,565 pages (25.6k results)
Published on Jan 23, 2019in Journal of Neurology, Neurosurgery, and Psychiatry8.27
Margaret Jane Moore1
Estimated H-index: 1
(University of Oxford),
Kathleen Vancleef7
Estimated H-index: 7
(University of Oxford)
+ 2 AuthorsNele Demeyere11
Estimated H-index: 11
(University of Oxford)
Unilateral visual neglect is characterised by lateralised spatial–attentional deficits, resulting in dramatic behavioural impairments.1 Neglect negatively impacts functional outcome and needs to be successfully detected in order to inform neglect-specific as well as general post-stroke rehabilitation goals and strategies. It is therefore critically important to evaluate current clinical methods for detecting and measuring the extent of this syndrome. Observational neurological assessments, such ...
Published on Apr 16, 2019in Journal of Neurology, Neurosurgery, and Psychiatry8.27
Helmar C. Lehmann23
Estimated H-index: 23
David Burke77
Estimated H-index: 77
(USYD: University of Sydney),
Satoshi Kuwabara58
Estimated H-index: 58
(Chiba University)
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated neuropathy typically characterised by symmetrical involvement, and proximal as well as distal muscle weakness (typical CIDP). However, there are several ‘atypical’ subtypes, such as multifocal acquired demyelinating sensory and motor neuropathy (Lewis-Sumner syndrome) and ‘distal acquired demyelinating symmetric neuropathy’, possibly having different immunopathogenesis and treatment responses. In the absence of diagno...
Published on Jun 21, 2019in Journal of Neurology, Neurosurgery, and Psychiatry8.27
Richard Hughes76
Estimated H-index: 76
(UCL: University College London)
Chronic inflammatory neuropathies include multifocal motor neuropathy, which is purely motor and often associated with complement-fixing antibodies to ganglioside GM1, paraproteinaemic demyelinating neuropathy associated with IgM paraprotein and antibodies to myelin-associated glycoprotein, and a heterogeneous group of conditions collected under the umbrella term chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Understanding the cause and improving the treatment of CIDP requires...
Published on Jun 13, 2019in Journal of Neurology, Neurosurgery, and Psychiatry8.27
Robert Napier Simpson9
Estimated H-index: 9
(Glas.: University of Glasgow),
Sharon Anne Simpson27
Estimated H-index: 27
(Glas.: University of Glasgow)
+ 3 AuthorsStewart W. Mercer45
Estimated H-index: 45
(Glas.: University of Glasgow)
Objective Impairment of mental well-being (anxiety, depression, stress) is common among people with multiple sclerosis (PwMS). Treatment options are limited, particularly for anxiety. The aim of this study was to update our previous systematic review (2014) and evaluate via meta-analysis the efficacy of mindfulness-based interventions (MBIs) for improving mental well-being in PwMS. Methods Systematic searches for eligible randomised controlled trials (RCTs) were carried out in seven major databa...
Published on Dec 5, 2018in Journal of Neurology, Neurosurgery, and Psychiatry8.27
Vinojini Vivekanandam (UCL Institute of Neurology), Chandrashekar Hoskote + 1 AuthorsMary M. Reilly47
Estimated H-index: 47
(UCL Institute of Neurology)
We read with interest the study by Koutsis et al reporting an increased prevalence of multiple sclerosis (MS) in their cohort of patients with X linked Charcot-Marie-Tooth disease (CMTX1).1 CMTX1 is a neurological condition with significant disability. The suggestion that CMTX1 may be a risk factor for developing MS will be of significant concern for these patients. We have a large cohort of patients with CMTX1 (n=133) in our centre. We reviewed the clinical records and MRI brains in our cohort ...
Published on May 23, 2019in Journal of Neurology, Neurosurgery, and Psychiatry8.27
Sarah-Jane Martin , Sarah McGlasson6
Estimated H-index: 6
(Edin.: University of Edinburgh)
+ 1 AuthorsJames Overell6
Estimated H-index: 6
Objective Neurofilament is a biomarker of axonal injury proposed as a useful adjunct in the monitoring of patients with multiple sclerosis (MS). We conducted a systematic review and meta-analysis of case–control studies that have measured neurofilament light chain (NfL) levels in cerebrospinal fluid (CSF) of people with MS (pwMS), in order to determine whether, and to what degree, CSF NfL levels differentiate MS from controls, or the subtypes or stages of MS from each other. Methods Guidelines o...
Published on Jun 21, 2019in Journal of Neurology, Neurosurgery, and Psychiatry8.27
Shohei Ikeda3
Estimated H-index: 3
(Nagoya University),
Haruki Koike31
Estimated H-index: 31
(Nagoya University)
+ 4 AuthorsGen Sobue79
Estimated H-index: 79
(Nagoya University)
Objective To evaluate the clinical and pathological correlations characterising each clinical subtype of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Methods We assessed 106 consecutive patients who had CIDP fulfilling the European Federation of Neurological Societies and Peripheral Nerve Society criteria and had been referred for sural nerve biopsy. Patients with anti-neurofascin 155, anti-contactin 1 and anti-LM1 antibodies were excluded. Results 55 patients were classifie...
Published on May 23, 2019in Journal of Neurology, Neurosurgery, and Psychiatry8.27
Lieke H.H. Meeter7
Estimated H-index: 7
(EUR: Erasmus University Rotterdam),
Rebecca M. E. Steketee6
Estimated H-index: 6
(EUR: Erasmus University Rotterdam)
+ 44 AuthorsNicholas Olney2
Estimated H-index: 2
(UCSF: University of California, San Francisco)
Background: Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need robust monitoring biomarkers to measure their efficacy. In different FTLD subtypes, neurofilament light chain (NfL) is a promising marker, therefore we inves...
Published on Apr 11, 2019in Journal of Neurology, Neurosurgery, and Psychiatry8.27
Ruben P.A. van Eijk5
Estimated H-index: 5
(UU: Utrecht University),
James Rooney13
Estimated H-index: 13
(Trinity College, Dublin)
+ 1 AuthorsLeonard H. van den Berg84
Estimated H-index: 84
(UU: Utrecht University)
Kaji et al recently conducted a phase II/III clinical trial to evaluate the safety and efficacy of methylcobalamin in 343 patients with amyotrophic lateral sclerosis (ALS).1 Both coprimary endpoints (survival and ALS Functional Rating Scale [ALSFRS-R]) failed to show significant benefit (p=0.19 and p=0.13, respectively). The choice for two coprimary endpoints is interesting and may have circumvented important pitfalls encountered by previous ALS trials.2 As ALS significantly reduces the patient’...
Published on Feb 13, 2019in Journal of Neurology, Neurosurgery, and Psychiatry8.27
Roisin McMackin1
Estimated H-index: 1
(Trinity College, Dublin),
Muthuraman Muthuraman18
Estimated H-index: 18
(University of Mainz)
+ 5 AuthorsOrla Hardiman64
Estimated H-index: 64
(Trinity College, Dublin)
Advanced neuroimaging has increased understanding of the pathogenesis and spread of disease, and offered new therapeutic targets. MRI and positron emission tomography have shown that neurodegenerative diseases including Alzheimer’s disease (AD), Lewy body dementia (LBD), Parkinson’s disease (PD), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are associated with changes in brain networks. However, the underlying neurophysiological pathways driving ...