Neurocognitive function and dysfunction after hepatitis C therapy

We read with interest the elegant study by Kraus et al.1 in the August issue of Hepatology. We have some concerns with regard to possible bias due to confounding factors not taken into account in the study. It is well known that not only depression but also the emotional state of the patient and motivation alone can modify neurocognitive function. It is very common for interferon alpha (IFN-α) therapy to induce depression or dysthymia.2 The...