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José A. Solís-Herruzo
Complutense University of Madrid
75Publications
22H-index
1,751Citations
Publications 75
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#1Inmaculada García-Ruiz (Complutense University of Madrid)H-Index: 11
#2Pablo Solís-Muñoz (University of Cambridge)H-Index: 12
Last.José A. Solís-Herruzo (Complutense University of Madrid)H-Index: 22
view all 6 authors...
Visceral fat deposition is associated with impairment of glucose and lipid metabolism while leptin levels are frequently related to subcutaneous fat area. At present, there is considerable controversy regarding the role of visceral adipose tissue accumulation in the development of metabolic syndrome (MS). Here we show the effects of omentectomy on the liver and MS in a diet induced obesity rat model. Our results reveal that undergoing omentectomy previously the establishment of the diet-induced-...
2 CitationsSource
#1Pablo Solís-Muñoz (University of Cambridge)H-Index: 12
#2Christopher Willars (University of Cambridge)H-Index: 8
Last.José A. Solís-HerruzoH-Index: 22
view all 7 authors...
Introduction Patients with acutely decompensated (AD) cirrhosis are at risk for developing acute-on-chronic liver failure (ACLF) syndrome. This syndrome is associated with a high short-term mortality rate. The aim of our study was to identify reliable early predictors of developing ACLF in cirrhotic patients with AD. Patients and Methods We assessed 84 cirrhotic patients admitted for AD without ACLF on admission. We performed routine blood testing and detailed ultrasound Doppler studies of syste...
1 CitationsSource
#1Martina BuckH-Index: 17
Last.Mario ChojkierH-Index: 44
view all 3 authors...
Inflammation contributes to the pathogenesis of most acute and chronic liver diseases1. Excessive liver injury and inflammation associated with liver diseases induced by viral, toxic, immunologic, and metabolic diseases2 results in liver dysfunction and in chronic conditions in the potential deposition of scar tissue and the development of cirrhosis, which is in turn a major contributor to the morbidity and mortality of patients affected by chronic liver diseases2,3. We first reported that ampli...
1 CitationsSource
NADPH oxidase is implicated in the pathogenesis of oxidative phosphorylation dysfunction in mice fed a high-fat diet
11 CitationsSource
#1Inmaculada García-Ruiz (Complutense University of Madrid)H-Index: 11
#2Pablo Solís-MuñozH-Index: 12
Last.José A. Solís-Herruzo (Complutense University of Madrid)H-Index: 22
view all 5 authors...
Activity of the oxidative phosphorylation system (OXPHOS) is decreased in humans and mice with nonalcoholic steatohepatitis. Nitro-oxidative stress seems to be involved in its pathogenesis. The aim of this study was to determine whether fatty acids are implicated in the pathogenesis of this mitochondrial defect. In HepG2 cells, we analyzed the effect of saturated (palmitic and stearic acids) and monounsaturated (oleic acid) fatty acids on: OXPHOS activity; levels of protein expression of OXPHOS ...
32 CitationsSource
#1Inmaculada García-Ruiz (Complutense University of Madrid)H-Index: 11
#2Pablo Solís-Muñoz (University of Cambridge)H-Index: 12
Last.José A. Solís-Herruzo (Complutense University of Madrid)H-Index: 22
view all 7 authors...
Nonalcoholic fatty liver disease (NAFLD) is the most frequent histological finding in individuals with abnormal liver-function tests in the Western countries. In previous studies, we have shown that oxidative phosphorylation (OXPHOS) is decreased in individuals with NAFLD, but the cause of this mitochondrial dysfunction remains uncertain. The aims of this study were to determine whether feeding mice a high-fat diet (HFD) induces any change in the activity of OXPHOS, and to investigate the mechan...
35 CitationsSource
#1Pablo Solís-MuñozH-Index: 12
#2Carlos Mingote‐Adán (Hospital Clínico San Carlos)H-Index: 1
Last.José A. Solís-HerruzoH-Index: 22
view all 3 authors...
1 CitationsSource
#1Pablo Solís-Muñoz (University of Cambridge)H-Index: 12
view all 3 authors...
Background Adenoma and polyp detection rates (ADR and PDR, respectively) are important indicators of endoscopy quality, particularly in colorectal carcinoma screening. Objective To assess the influence of the endoscopist's experience on the ADR and PDR. Patients and Methods In this study, 9635 colonoscopies were screened during a 5-year period. Only 5738 were finally analyzed due to exclusion criteria. The endoscopists were separated in three groups of experience according to the number of colon...
8 CitationsSource
AIM: To determine the causes and characteristics of fecal incontinence in men and to compare these features with those presented by a group of women with the same problem.
13 CitationsSource
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