Last. Guoyong Han(Academy of Medical Sciences, United Kingdom)H-Index: 6
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The development and progression of hepatocellular carcinoma (HCC) is dependent on its local microenvironment. Tumor-associated macrophages (TAMs) are deemed as a key factor for the tumor microenvironment and attribute to contribute to tumor aggressiveness. However, the detailed mechanism underlying the pro-metastatic effect of TAMs on HCC remains undefined. The present study manifested that TAMs were enriched in HCC. TAMs were characterized by an M2-polarized phenotype and accelerated migratory ...
#1Fuzhen Wang(CCDC: Chinese Center for Disease Control and Prevention)H-Index: 14
#2Xiaojin Sun(CCDC: Chinese Center for Disease Control and Prevention)H-Index: 5
Last. Fuqiang Cui(PKU: Peking University)H-Index: 16
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China has conducted surveillance for hepatitis A since 1990, and was highly-to-intermediately endemic in 1992 when a Chinese hepatitis A vaccine (HepA) was licensed and introduced as a family-pay vaccine. In 2008, HepA was introduced into the Expanded Program on Immunization as a free childhood vaccine. Three nationally-representative surveys, conducted in 1992, 2006, and 2014, assessed hepatitis B serology. The 1992 survey included hepatitis A virus (HAV) serology, and we tested sera from the 2...
#1Minxuan Xu(UEW: University of Education, Winneba)H-Index: 5
#2Chenxu Ge(UEW: University of Education, Winneba)H-Index: 5
Last. Xianling Dai(UEW: University of Education, Winneba)H-Index: 1
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Non-alcoholic fatty liver disease (NAFLD) has been widely recognized as a precursor to metabolic complications. Elevated inflammation levels are predictive of NAFLD-associated metabolic disorder. Inactive rhomboid-like protein 2 (iRhom2) is regarded as a key regulator in inflammation. However, the precise mechanisms by which iRhom2-regulated inflammation promotes NAFLD progression remain to be elucidated. Here, we report that insulin resistance, hepatic steatosis, and specific macrophage inflamm...
Hepatic hydrothorax is the formation of transudative pleural effusion as a consequence of portal hypertension. Only a minority of cases resolve after sodium restriction and diuretics. Despite the relatively low incidence of 5-15% among patients with cirrhotic portal hypertension, the high morbidity and serious clinical implications associated with hepatic hydrothorax necessitate a well-defined treatment strategy to guide patient care. Management is typically multidisciplinary, involving hepatolo...
We read the recent article published by Mehta and colleagues with great interest (1). The authors state that UNOS have developed a policy of reducing the pretransplant alfa-feto protein (AFP) from 1000 to below 500 ng/ml by locoregional therapy (LRT). Although it is known fact that AFP>1000 ng/ml is a significant risk factor for recurrence even in patients with HCC within the Milan criteria, 72% of the patients in the present study have an AFP>1000 ng/ml and this point should be explained. About...
#1Neil Mehta(UCSF: University of California, San Francisco)H-Index: 26
#2Francis Y. Yao(UCSF: University of California, San Francisco)H-Index: 33
We thank Akbulut et al for their letter to the editor (1) on our study (2) which analyzed patients with hepatocellular carcinoma (HCC) in the UNOS database with at least one measured AFP >1000 ng/ml prior to liver transplant (LT). We validated recently approved national policy (3) by demonstrating significantly improved post-LT outcome among patients with a reduction in AFP to 70% of patients included in this study did not fulfill this national policy and also pointed out that over one-third of ...
#2Qinghong Li(UMCG: University Medical Center Groningen)H-Index: 1
Last. Arend W. Overeem(UMCG: University Medical Center Groningen)H-Index: 5
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Mutations in the MYO5B gene cause in some patients low gamma-glutamyltransferase (low-GGT) cholestatic liver disease (CLD) and in other patients microvillus inclusion disease (MVID, a congenital diarrheal and malabsorption disorder). Overlap of symptoms occurs but more MVID patients present cholestasis than CLD patients present diarrhea. Clinical observations indicate that MYO5B mutations can cause but also protect against CLD. This complicates family counseling and therapeutic decisions. Here w...
Increased use of novel immunomodulatory agents has led to emerging forms of drug-induced liver injury. Alemtuzumab is a recombinant, humanized monoclonal antibody against CD52, which is present on T cells, B cells, monocytes and natural killer cells. A single dose results in a depletion of the entire lymphocyte population followed by varied kinetics in the recovery of each cell type. Alemtuzumab has been approved as an immune reconstitution therapy in relapsing and remitting multiple sclerosis (...
Endoplasmic reticulum (ER) stress is an adaptive response to excessive ER demand and contributes to the development of numerous diseases, including nonalcoholic fatty liver disease (NAFLD) that is hallmarked by the accumulation of lipid within hepatocytes. However, the underlying mechanisms remain elusive. MicroRNAs (miRNAs) play an indispensable role in various stress responses, but their implications in ER stress have not yet been systemically investigated. In this study, we identify a negativ...