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Clitoria ternatea and the CNS

Published on Jun 1, 2003in Pharmacology, Biochemistry and Behavior 2.77
· DOI :10.1016/S0091-3057(03)00130-8
Neeti N Jain1
Estimated H-index: 1
,
C.C Ohal1
Estimated H-index: 1
+ 4 AuthorsSanjay Kasture17
Estimated H-index: 17
Cite
Abstract
The present investigation was aimed at determining the spectrum of activity of the methanolic extract of Clitoria ternatea (CT) on the CNS. The CT was studied for its effect on cognitive behavior, anxiety, depression, stress and convulsions induced by pentylenetetrazol (PTZ) and maximum electroshock (MES). To explain these effects, the effect of CT was also studied on behavior mediated by dopamine (DA), noradrenaline, serotonin and acetylcholine. The extract decreased time required to occupy the central platform (transfer latency, TL) in the elevated plus maze (EPM) and increased discrimination index in the object recognition test, indicating nootropic activity. The extract was more active in the object recognition test than in the EPM. The extract increased occupancy in the open arm of EPM by 160% and in the lit box of the light/dark exploration test by 157%, indicating its anxiolytic activity. It decreased the duration of immobility in tail suspension test (suggesting its antidepressant activity), reduced stress-induced ulcers and reduced the convulsing action of PTZ and MES. The extract exhibited tendency to reduce the intensity of behavior mediated via serotonin and acetylcholine. The effect on DA- and noradrenaline-mediated behavior was not significant. In conclusion, the extract was found to possess nootropic, anxiolytic, antidepressant, anticonvulsant and antistress activity. Further studies are necessary to isolate the active principle responsible for the activities and to understand its mode of action.
  • References (47)
  • Citations (99)
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References47
Newest
Published on Aug 1, 2002in Journal of Ethnopharmacology 3.41
Sd Chintawar2
Estimated H-index: 2
,
R.S Somani3
Estimated H-index: 3
+ 1 AuthorsSanjay Kasture17
Estimated H-index: 17
The effect of saponin containing n-butanolic fraction (BF) extracted from dried leaves of Albizzia lebbeck on learning and memory was studied in albino mice using passive shock avoidance paradigm and the elevated plus maze. Significant improvement was observed in the retention ability of the normal and amnesic mice as compared to their respective controls. We have also studied the effects of BF on the behavior influenced by serotonin (5-HT), noradrenaline and dopamine. The brain levels of seroto...
Kiranmai S. Rai7
Estimated H-index: 7
(Manipal University),
Murthy Kd3
Estimated H-index: 3
+ 1 AuthorsMuddanna S. Rao23
Estimated H-index: 23
Neonatal rat pups (7 days old) were intubated with either 50 mg/kg body weight or 100 mg/kg body weight of aqueous root extract of Clitoria ternatea (CTR) for 30 days. These rats were then subjected to open field, two compartment passive avoidance and spatial learning (T-Maze) tests (i) immediately after the treatment and (ii) 30 days after the treatment, along with age matched normal and saline control rats. Results showed no change in open field behaviour, but showed improved retention and spa...
Published on Jan 1, 2000in Pharmaceutical Biology 2.49
A.D. Taranalli1
Estimated H-index: 1
,
T.C. Cheeramkuzhy1
Estimated H-index: 1
Clitoria ternatea , commonly known as Shankpushpi, is widely used in the traditional Indian system of medicine as a brain tonic and is believed to promote memory and intelligence. We examined the effectiveness of alcoholic extracts of aerial and root parts of C. ternatea at 300 and 500 mg/kg doses orally in rats in attenuating electroshock-induced amnesia. Extracts at 300 mg/kg dose produced significant memory retention, and the root parts were found to be more effective. In order to delineate t...
Published on Aug 1, 1999in Neuropharmacology 4.37
Nicholas M. Barnes29
Estimated H-index: 29
(University of Birmingham),
T. Sharp15
Estimated H-index: 15
It is now nearly 5 years since the last of the currently recognised 5-HT receptors was identified in terms of its cDNA sequence. Over this period, much effort has been directed towards understanding the function attributable to individual 5-HT receptors in the brain. This has been helped, in part, by the synthesis of a number of compounds that selectively interact with individual 5-HT receptor subtypes—although some 5-HT receptors still lack any selective ligands (e.g. 5-ht1E, 5-ht5A and 5-ht5B ...
Published on Mar 23, 1998in Psychopharmacology 3.42
Andras Bilkei-Gorzo3
Estimated H-index: 3
(Egis Group),
Istvan Gyertyan22
Estimated H-index: 22
(Egis Group),
György Lévay17
Estimated H-index: 17
(Egis Group)
The activity of anxiolytic and other drugs in a light-dark test situation was studied in rats treated with the anxiogenic compound m-chlorophenyl-piperazine (mCPP). mCPP 0.5 mg/kg significantly diminished the exploratory activity of the animals in the light compartment of the apparatus. Drugs to be tested against mCPP-induced anxiety when studied alone (not in combination with mCPP) did not significantly alter the activity of rats in the light-dark apparatus, except yohimbine, which reduced the ...
Alfredo Meneses36
Estimated H-index: 36
(CINVESTAV),
Enrique Hong18
Estimated H-index: 18
(CINVESTAV)
Abstract 1. 1. The authors have tested several 5-HT selective agonists and antagonists (5-HT 1A/1B , 5-HT 1A/2B/2C , 5-HT 3 or 5-HT 4 ), an uptake inhibitor and 5-HT depletors in the autoshaping learning task. 2. 2. The present work deals with the receptors whose stimulation increases or decreases learning. 3. 3. Impaired consolidation of learning was observed after the presynaptic activation of 5-HT 1B , 5-HT 3 or 5-HT 4 or the blockade of postsynaptic 5-HT 2C/2B receptors. 4. 4. In contrast, a...
Published on Jan 1, 1997in Neurobiology of Aging 4.40
Amy F.T. Arnsten71
Estimated H-index: 71
(Yale University),
C. Huie Lin3
Estimated H-index: 3
(Yale University)
+ 1 AuthorsKelly J. Stanhope1
Estimated H-index: 1
Abstract The serotonin 5-HT 3 receptor antagonists ondansetron and SEC-579 were tested over a wide dose range (0.000001–0.5 mg/kg, PO) for cognitive-enhancing effects in aged rhesus monkeys. Animals were tested on the following cognitive and motor tasks: 1) acquisition of a visual object discrimination; 2) reversal of a visual object discrimination; 3) the delayed response task, a spatial working memory task; and 4) a fine motor task. This study found enhanced acquisition of a visual object disc...
Imaizumi M1
Estimated H-index: 1
,
Miyazaki S11
Estimated H-index: 11
,
Onodera K1
Estimated H-index: 1
The effects of theophylline were examined in a light/dark test in p-chlorophenylalanine (PCPA)-treated mice to investigate serotonergic contribution to its effects. Three consecutive treatments with PCPA (200 mg/kg once daily) barely affected parameters in the light/dark test. In vehicle- and PCPA-treated mice theophylline (100 mg/kg) significantly decreased time spent in the light zone, which suggested its anxiogenic-like activity. In PCPA-treated mice, theophylline (50 mg/kg) also tended to de...
Published on Feb 1, 1996in Pharmacology, Biochemistry and Behavior 2.77
L. Bartolini18
Estimated H-index: 18
(UniFI: University of Florence),
Fiorella Casamenti38
Estimated H-index: 38
(UniFI: University of Florence),
Giancarlo Pepeu56
Estimated H-index: 56
(UniFI: University of Florence)
Object recognition was investigated in adult and aging male rats in a two-trials, unrewarded, test that assessed a form of working-episodic memory. Exploration time in the first trial, in which two copies of the same object were presented, was recorded. In the second trial, in which one of the familiar objects and a new object were presented, the time spent exploring the two objects was separately recorded and a discrimination index was calculated. Adult rats explored the new object longer than ...
Published on Jul 17, 1995in FEBS Letters 2.67
Rupert William Osborn14
Estimated H-index: 14
,
Genoveva W. De Samblanx5
Estimated H-index: 5
(Catholic University of Leuven)
+ 6 AuthorsWillem F. Broekaert57
Estimated H-index: 57
(Catholic University of Leuven)
Abstract From seeds of Aesculus hippocastanum, Clitoria ternatea, Dahlia merckii and Heuchera sanguinea five antifungal proteins were isolated and shown to be homologous to plant defensins previously characterised from radish seeds and γ-thionins from Poaceae seeds. Based on the spectrum of their antimicriobial activity and the morphological distortions they induce on fungi the peptides can be divided into two classes. The peptides did not inhibit any of three different α-amylases.
Cited By99
Newest
Published on Dec 1, 2019in Scientific Reports 4.01
Neha Choudhary1
Estimated H-index: 1
(Central University of Himachal Pradesh),
Vikram Singh2
Estimated H-index: 2
(Central University of Himachal Pradesh)
Epilepsy, that comprises a wide spectrum of neuronal disorders and accounts for about one percent of global disease burden affecting people of all age groups, is recognised as apasmara in the traditional medicinal system of Indian antiquity commonly known as Ayurveda. Towards exploring the molecular level complex regulatory mechanisms of 63 anti-epileptic Ayurvedic herbs and thoroughly examining the multi-targeting and synergistic potential of 349 drug-like phytochemicals (DPCs) found therein, i...
Published on Jul 1, 2019in Journal of Herbal Medicine 1.55
Swati Vyas2
Estimated H-index: 2
(University of Rajasthan),
S. L. Kothari22
Estimated H-index: 22
(University of Rajasthan),
Sumita Kachhwaha13
Estimated H-index: 13
(University of Rajasthan)
Abstract With the rise in the ageing population in the last few decades, dementia has emerged as a serious global health issue. Alzheimer's disease (AD) is the most common type of dementia. Despite extensive drug development research, only a limited number of FDA-approved drugs are available for AD. As these drugs provide symptomatic relief only and are frequently associated with adverse effects, there remains an urgent need for developing alternative approaches to AD therapeutics. Several medic...
Published on Nov 9, 2018in Molecular Neurobiology 4.59
Md. Sahab Uddin7
Estimated H-index: 7
(SEU: Southeast University),
Abdullah Al Mamun2
Estimated H-index: 2
(SEU: Southeast University)
+ 4 AuthorsGhulam Md Ashraf15
Estimated H-index: 15
(KAU: King Abdulaziz University)
Medicinal plants are the backbone of modern medicine. In recent times, there is a great urge to discover nootropic medicinal plants to reverse cognitive dysfunction owing to their less adverse effects. Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by the inevitable loss of cognitive function, memory and language impairment, and behavioral disturbances, which turn into gradually more severe. Alzheimer’s has no current cure, but symptomatic treatments are avai...
Published on May 28, 2019in Frontiers in Plant Science 4.11
Georgianna Kae Oguis1
Estimated H-index: 1
(UQ: University of Queensland),
Edward K. Gilding12
Estimated H-index: 12
(UQ: University of Queensland)
+ 1 AuthorsDavid J. Craik82
Estimated H-index: 82
(UQ: University of Queensland)
The perennial leguminous herb Clitoria ternatea (butterfly pea) has attracted significant interest based on its agricultural and medical applications, which range from use as a fodder and nitrogen fixing crop, to applications in food coloring and cosmetics, traditional medicine and as a source of an ecofriendly insecticide. In this article we provide a broad multidisciplinary review that includes descriptions of the physical appearance, distribution, taxonomy, habitat, growth and propagation, ph...
Published on Mar 1, 2019in Ultrasonics Sonochemistry 7.28
Arshad Mehmood2
Estimated H-index: 2
(BTBU: Beijing Technology and Business University),
Muhammad Ishaq1
Estimated H-index: 1
(BTBU: Beijing Technology and Business University)
+ 5 AuthorsChengtao Wang13
Estimated H-index: 13
(BTBU: Beijing Technology and Business University)
Abstract The present study was conducted to evaluate the influence of ultrasound on bioactive compounds and biological activities of blue butterfly pea flower ( Clitoria ternatea L . ). For this purpose, optimized conditions (temperature 50 °C, time 150 min, solid to liquid ratio 1 g:15 ml, 70% amplitude and 240 W, 20 kHz frequency, 3 s on and 3 s off) of ultrasound (US) and conventional extraction (AGE: Agitation, water bath for 150 min, 50 °C at 150 rmp) were used. The results showed significa...
Published on Oct 1, 2018in Journal of Ethnopharmacology 3.41
Thenmoly Damodaran2
Estimated H-index: 2
(Universiti Sains Malaysia),
Byorn Wei Liang Tan1
Estimated H-index: 1
+ 3 AuthorsZurina Hassan (Universiti Sains Malaysia)
Abstract Ethnopharmacological relevance Clitoria ternatea L. (CT), commonly known as Butterfly pea, is used in Indian Ayurvedic medicine to promote brain function and treat mental disorders. Root of CT has been proven to enhance memory, but its role in an animal model of chronic cerebral hypoperfusion (CCH), which has been considered as a major cause of brain disorders, has yet to be explored. Aim of the study To assess the motor and cognitive effects of acute oral administration of CT root meth...
Published on Aug 1, 2018in Biomedicine & Pharmacotherapy 3.74
Jeanette Martins1
Estimated H-index: 1
,
S Brijesh6
Estimated H-index: 6
Abstract Stress renders an individual to experience mental pressure and exhaustion which brings about feelings of anxiety, depression, anger and/or other negative emotions. Depression affects a person’s state of mind, behaviour, health and is often associated with suicide. The use of anti-depressant drugs as therapeutic agents is associated with symptoms such as, delayed onset of action, side-effects, drug–drug and dietary interactions, sexual dysfunction, cardiac toxicity, etc. Thus, there is n...
Published on Jun 1, 2018in Metabolic Brain Disease 2.41
Zubia Begum1
Estimated H-index: 1
(Hamdard University),
Ishrat Younus2
Estimated H-index: 2
(Hamdard University)
The current study was designed with the aim to investigate anti-anxiety potential of Hibiscus rosa sinensis roots and its possible mechanism of action. For this purpose hole board test, elevated plus maze test and light/dark exploration test were employed. The ethanol extract of plant was administered orally at two different doses i.e. 100 and 500 mg/kg for consecutive 14 days. The results of present investigation indicate that plant extract significantly (p < 0.05) increased the number of head ...
Published on Jan 1, 2018
A. V. Deepa1
Estimated H-index: 1
(Central University of Kerala),
M. Anju1
Estimated H-index: 1
(Central University of Kerala),
T. Dennis Thomas2
Estimated H-index: 2
(Central University of Kerala)
Thidiazuron (TDZ; N-phenyl-1, 2, 3-thidiazole-5ylurea) is a cytokinin-like compound routinely used for in vitro culture studies including shoot proliferation and regeneration in various plants. Recently, there is an increased use of TDZ in in vitro propagation of plants including medicinal and horticultural crops. TDZ was found to be more effective in micropropagation, multiple shoot induction, somatic embryogenesis, callus induction, and shoot organogenesis as compared to other cytokinins. In s...
Published on Feb 1, 2017in Journal of Ethnopharmacology 3.41
Kothanahalli S. Raghu1
Estimated H-index: 1
(Manipal University),
Bhanuvalli R. Shamprasad1
Estimated H-index: 1
(Manipal University)
+ 5 AuthorsKapaettu Satyamoorthy33
Estimated H-index: 33
(Manipal University)
Abstract Ethnopharmacological relevance Indian traditional medicinal system in Ayurveda suggests several preparations, known as medhya rasayanas, of diverse plant origin to enhance the health in general, reduce stress and improve brain function in particular during ageing. These effects in the context of contemporary knowledge and the underlying mechanisms are not clearly understood. Autophagy and DNA damage induced repair are inter-related quintessential pathways and are significantly altered d...