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Clitoria ternatea and the CNS
Abstract
The present investigation was aimed at determining the spectrum of activity of the methanolic extract of Clitoria ternatea (CT) on the CNS. The CT was studied for its effect on cognitive behavior, anxiety, depression, stress and convulsions induced by pentylenetetrazol (PTZ) and maximum electroshock (MES). To explain these effects, the effect of CT was also studied on behavior mediated by dopamine (DA), noradrenaline, serotonin and acetylcholine. The extract decreased time required to occupy the central platform (transfer latency, TL) in the elevated plus maze (EPM) and increased discrimination index in the object recognition test, indicating nootropic activity. The extract was more active in the object recognition test than in the EPM. The extract increased occupancy in the open arm of EPM by 160% and in the lit box of the light/dark exploration test by 157%, indicating its anxiolytic activity. It decreased the duration of immobility in tail suspension test (suggesting its antidepressant activity), reduced stress-induced ulcers and reduced the convulsing action of PTZ and MES. The extract exhibited tendency to reduce the intensity of behavior mediated via serotonin and acetylcholine. The effect on DA- and noradrenaline-mediated behavior was not significant. In conclusion, the extract was found to possess nootropic, anxiolytic, antidepressant, anticonvulsant and antistress activity. Further studies are necessary to isolate the active principle responsible for the activities and to understand its mode of action.
  • References (47)
  • Cited By (97)
Kiranmai S. Rai5
Estimated H-index: 5
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Murthy Kd3
Estimated H-index: 3
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Karanth Ks2
Estimated H-index: 2
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Neonatal rat pups (7 days old) were intubated with either 50 mg/kg body weight or 100 mg/kg body weight of aqueous root extract of Clitoria ternatea (CTR) for 30 days. These rats were then subjected to open field, two compartment passive avoidance and spatial learning (T-Maze) tests (i) immediately after the treatment and (ii) 30 days after the treatment, along with age matched normal and saline control rats. Results showed no change in open field behaviour, but showed improved retention and spa...
Ref 8Cited 45
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Paul A. J. Janssen62
Estimated H-index: 62
(Janssen Pharmaceutica)
Publisher Summary This chapter discusses the evolution of two butyrophenones—namely, haloperidol and trifluperidol, from meperidine-like 4-phenylpiperidines The clinical results obtained with haloperidol and trifluperidol are predictable from animal data. Haloperidol and trifluperidol are indeed powerful neuroleptic drugs or major tranquilizers for man. Both the drugs are about equally active orally as parenterally. Haloperidol, longer acting than trifluperidol, is being used at daily close leve...
Ref 26Cited 43
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Robert S. Fisher57
Estimated H-index: 57
(Johns Hopkins University School of Medicine)
Abstract The study of mechanisms of the epilepsies requires employment of animal models. Choice of a model system depends upon several factors, including the question to be studied, the type of epilepsy to be modelled, familiarity and convenience. Over 50 models are reviewed. Major categories of models are those for simple partial seizures: topical convulsants, acute electrical stimulation, cortically implanted metals, cryogenic injury; for complex partial seizures: kainic acid, tetanus toxin, i...
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J.N. Crawley1
Estimated H-index: 1
Abstract A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05...
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M. Wielosz1
Estimated H-index: 1
,
Z. Kleinrok1
Estimated H-index: 1
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Amy F.T. Arnsten70
Estimated H-index: 70
(Yale University),
C. Huie Lin3
Estimated H-index: 3
(Yale University),
Christopher H. van Dyck43
Estimated H-index: 43
(Yale University)
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Abstract The serotonin 5-HT 3 receptor antagonists ondansetron and SEC-579 were tested over a wide dose range (0.000001–0.5 mg/kg, PO) for cognitive-enhancing effects in aged rhesus monkeys. Animals were tested on the following cognitive and motor tasks: 1) acquisition of a visual object discrimination; 2) reversal of a visual object discrimination; 3) the delayed response task, a spatial working memory task; and 4) a fine motor task. This study found enhanced acquisition of a visual object disc...
Ref 33Cited 51
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2002 in Journal of Ethnopharmacology [IF: 2.98]
S.D Chintawar1
Estimated H-index: 1
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R.S Somani1
Estimated H-index: 1
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Veena S Kasture1
Estimated H-index: 1
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The effect of saponin containing n-butanolic fraction (BF) extracted from dried leaves of Albizzia lebbeck on learning and memory was studied in albino mice using passive shock avoidance paradigm and the elevated plus maze. Significant improvement was observed in the retention ability of the normal and amnesic mice as compared to their respective controls. We have also studied the effects of BF on the behavior influenced by serotonin (5-HT), noradrenaline and dopamine. The brain levels of seroto...
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1995 in Pharmacology & Therapeutics [IF: 11.13]
H.H.G. Berendsen1
Estimated H-index: 1
(Organon International)
Abstract The purpose of this review is to describe the consequences of antidepressant treatment on the behaviour of rodents after activation of serotonin (5-hydroxytryptamine, 5-HT) receptor subtypes. In a summary table, the involvement of 5-HT receptors in inducing behavioural changes are described. It is emphasized that these effects are not always only exclusively linked to serotonergic functions nor that they are only initiated by central 5-HT receptors. Hereafter the complex mutual inhibito...
Ref 175Cited 75
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  • References (47)
  • Cited By (97)
Anwar Shahzad13
Estimated H-index: 13
(Aligarh Muslim University),
Shahina Parveen5
Estimated H-index: 5
(Aligarh Muslim University)
Interest and support for the conservation and development of medicinal plants is increasing in all parts of the world. This is due, in part, to a growing recognition given to the role of medicinal plants in the provision of culturally relevant and affordable health care in creating sustainable livelihoods and in the vital conservation of biodiversity. This has also drawn the attention of the world community towards the need for creating mechanisms to ensure sustained development of the sector an...
Ref 85
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Shaily Goyal6
Estimated H-index: 6
,
Jaya Arora3
Estimated H-index: 3
,
Kishan G. Ramawat10
Estimated H-index: 10
Aravalli hills are hot spot of subtropical plant biodiversity. The tribal people of the region partially or fully depend upon herbal drugs for primary healthcare. Overexploitation of these plants has made several of them as endangered species. The present paper aimed to document the biotechnological approaches being used to conserve ethnomedicinal plants of Aravalli Hills, the bioactive molecules present in them and their traditional uses and the modern scientific validation/assay of biological ...
Ref 327Cited 2
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M. S. Rabeta1
Estimated H-index: 1
Aqueous and methanol extracts of the flowers of Clitoria ternatea (CT), a popularly plant consumed for blue colour in Nasi Kerabu was selected to explore its cytotoxic effect on six types of normal and cancer-origin cell lines. These included the hormonedependent breast cancer cell line (MCF-7), non-hormone-dependent breast cancer cell line (MDA-MB-231), human ovary cancer cell line (Caov-3), human cervical cancer cell line (Hela), human liver cancer cell line (HepG2) and human foreskin fibrobla...
Ref 12Cited 4
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Chandana Choudhury Barua13
Estimated H-index: 13
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Jayanti Datta Roy4
Estimated H-index: 4
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Bhaben Buragohain4
Estimated H-index: 4
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Drymaria cordata hydroethanolic extract (DCHE) at 25, 50 and 100 mg/kg (po) was administered to study anxiolytic effect. Different models for anxiolytic activity viz. Hole board, Open field, Elevated plus maze, Light/dark exploration model were used. In the hole board model, there was dose dependent and significant increase in the numbers of head pokes and the time of head dipping in the treated groups in comparison to the vehicle. In open field test, the number of rearing, assisted rearing and ...
Ref 17Cited 23
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Sitaram Jaideep Sriranjini1
Estimated H-index: 1
(Microsoft),
Kumar Sandhya1
Estimated H-index: 1
,
Vernekar Sanjeeva Mamta1
Estimated H-index: 1
(Microsoft)
Abstract The understanding of epilepsy has progressed since its earliest impression as a disease associated with paranormal and superstitious beliefs. Landmark advances have been made in deciphering the pathophysiological substrates involved in the disease process, and treatment advances have contributed significantly to ameliorating the seizures. However, disease-modifying agents are yet to be discovered. Ayurveda is a system of medicine that stresses a holistic approach to disease, and treatme...
Ref 171Cited 2
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Sachin Kumar Jain1
Estimated H-index: 1
(Mangalayatan University),
Sumit Parihar1
Estimated H-index: 1
,
Neha Pandey1
Estimated H-index: 1
Neuropharmacology is the scientific study of the effects of drugs on the central nervous system. Its primary focus is actions of medications for psychiatric and neurologic disorders as well as those of drugs of abuse. The goal of Neuropharmacology is to apply information about drugs and their mechanisms of action, develop safer and more effective treatments and eventually curative and preventive measures for a host of nervous system abnormalities. There are a number of drugs being used in the tr...
Ref 80Cited 2
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Acetylcholinesterase (AChE) enzyme and oxidative stress play the crucial role in cognitive function. In addition, the effects of the plant extract can improve cognitive impairment. This study aimed to investigate the effect of C. ternatea flowers on cognitive enhancing effect, oxidative stress status and AChE inhibition in prefrontal cortex of normal male mice. The animals were grouped into five groups including control, vehicle and the extract at doses of 200, 400 and 800 mg/kg body weight. The...
Ref 18
Depression as a mental illness has many negative effects to people’s quality of life. The synthetic drugs has been developed to cure this illness but the side effect has compromized the therapy. Other side, the use of herbal medicine has been accepted in almost country in the world.The objective of this study is to find antidepressant drug from Indonesian herbal medicine. The study is an assessment derived from 53 publications of antidepressant effect of Indonesian herbal from national and inter...
Ref 27
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2011 in Journal of Ethnopharmacology [IF: 2.98]
Dnyaneshwar J. Taur6
Estimated H-index: 6
,
Ravindra Y Patil9
Estimated H-index: 9
Abstract Aim of study Clitoria ternatea L. (Family: Fabaceae) is being used in traditional medicine for the treatment of severe bronchitis and asthma. So the aim of study was to evaluate antiasthmatic activity of ethanol extract of Clitoria ternatea roots. Materials and methods In the present study ethanol extract of Clitoria ternatea root (ECTR) was evaluated for preliminary phytochemical screening, acute toxicity studies and antiasthmatic activity using milk induced leucocytosis and eosinophil...
Ref 21Cited 16
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