Fornix as an imaging marker for episodic memory deficits in healthy aging and in various neurological disorders

The fornix is a part of the limbic system and constitutes the major efferent and afferent white matter tracts from the hippocampi. The underdevelopment of or injuries to the fornix are strongly associated with memory deficits. Its role in memory impairments was suggested long ago with cases of surgical forniceal transaction. However, recent advances in brain imaging techniques, such as diffusion tensor imaging; enabling more qualitative and...