P1-345: Consequences of beta-amyloid immunotherapy for Alzheimer's disease on neurons in the human cerebral cortex

Alzheimer's disease (AD) patients in Aβ immunotherapy trials have demonstrated amyloid plaque removal but with little evidence of slowed cognitive decline. We have explored the consequences of immunotherapy on neuronal density and the morphology of neuronal processes. 11 immunised AD patients (iAD) (Elan Pharmaceuticals, AN1792) were compared to 28 non-immunised AD patients (cAD) as controls. Immunohistochemistry on sections of cortex from...