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Alzheimers & Dementia
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#1Richard S. Isaacson (Cornell University)H-Index: 10
#2Hollie Hristov (Cornell University)H-Index: 2
Last.Robert Krikorian (University of Cincinnati Academic Health Center)H-Index: 17
view all 28 authors...
Abstract Introduction Multidomain intervention for Alzheimer's disease (AD) risk reduction is an emerging therapeutic paradigm. Methods Patients were prescribed individually tailored interventions (education/pharmacologic/nonpharmacologic) and rated on compliance. Normal cognition/subjective cognitive decline/preclinical AD was classified as Prevention. Mild cognitive impairment due to AD/mild-AD was classified as Early Treatment. Change from baseline to 18 months on the modified Alzheimer's Pre...
#1Maria V. Pulina (Rockefeller University)H-Index: 7
#2Maya Hopkins (Rockefeller University)H-Index: 1
Last.Victor Bustos (Rockefeller University)H-Index: 11
view all 5 authors...
Abstract Introduction The levels and distribution of amyloid deposits in the brain does not correlate well with Alzheimer's disease (AD) progression. Therefore, it is likely that amyloid precursor protein and its proteolytic fragments other than amyloid β (Aβ) contribute to the onset of AD. Methods We developed a sensitive assay adapted to the detection of C99, the direct precursor of β-amyloid. Three postmortem groups were studied: control with normal and stable cognition; patients with moderat...
#1Sonia Moreno (ISCIII: Instituto de Salud Carlos III)H-Index: 21
#2Itziar de RojasH-Index: 2
Last.Agustín Ruiz (ISCIII: Instituto de Salud Carlos III)H-Index: 1
view all 177 authors...
Abstract Introduction Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. Methods Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathwa...
#1Ríona Mc Ardle (Newcastle University)H-Index: 2
#2Brook Galna (Newcastle University)H-Index: 26
Last.Lynn Rochester (Newcastle University)H-Index: 53
view all 5 authors...
Abstract Objective We aimed to refine the hypothesis that dementia has a unique signature of gait impairment reflective of underlying pathology by considering two dementia subtypes, Alzheimer's disease (AD) and Lewy body disease (LBD), and exploring the role of cognition in disease-specific gait impairments. Background Accurately differentiating AD and LBD is important for treatment and disease management. Early evidence suggests gait could be a marker of dementia due to associations between dis...
#1Rik Ossenkoppele (Lund University)H-Index: 19
#2Chul Hyoung Lyoo (Yonsei University)H-Index: 20
Last.Oskar Hansson (Lund University)H-Index: 64
view all 19 authors...
Abstract Introduction Differential patterns of brain atrophy on structural magnetic resonance imaging (MRI) revealed four reproducible subtypes of Alzheimer's disease (AD): (1) “typical”, (2) “limbic-predominant”, (3) “hippocampal-sparing”, and (4) “mild atrophy”. We examined the neurobiological characteristics and clinical progression of these atrophy-defined subtypes. Methods The four subtypes were replicated using a clustering method on MRI data in 260 amyloid-β–positive patients with mild co...
#1Jun Oh (University of California, Berkeley)H-Index: 3
#2Rana Eser (University of California, Berkeley)H-Index: 1
Last.Lea T. GrinbergH-Index: 43
view all 19 authors...
Abstract Introduction Sleep-wake disturbances are a common and early feature in Alzheimer's disease (AD). The impact of early tau pathology in wake-promoting neurons (WPNs) remains unclear. Methods We performed stereology in postmortem brains from AD individuals and healthy controls to identify quantitative differences in morphological metrics in WPNs. Progressive supranuclear palsy (PSP) and corticobasal degeneration were included as disease-specific controls. Results The three nuclei studied a...
#1Chih Hung Lo (UMN: University of Minnesota)H-Index: 2
#2Colin Kin-Wye Lim (UMN: University of Minnesota)
Last.Jonathan N. Sachs (UMN: University of Minnesota)H-Index: 25
view all 9 authors...
Abstract Objective Understanding the heterogeneous pathology in Alzheimer's disease and related tauopathies is one of the most urgent and fundamental challenges facing the discovery of novel disease-modifying therapies. Through monitoring ensembles of toxic and nontoxic tau oligomers spontaneously formed in cells, our biosensor technology can identify tool compounds that modulate tau oligomer structure and toxicity, providing much needed insight into the nature and properties of toxic tau oligom...
#1Alberto R. Ramos (UM: University of Miami)H-Index: 16
#2Wassim Tarraf (WSU: Wayne State University)H-Index: 16
Last.Hector M. González (UCSD: University of California, San Diego)H-Index: 25
view all 12 authors...
Abstract Introduction To determine if sleep-disordered breathing (SDB), daytime sleepiness, insomnia, and sleep duration predict seven-year neurocognitive decline in US Hispanics/Latinos (N = 5247). Methods The exposures were baseline SDB, daytime sleepiness, insomnia, and sleep duration. The outcomes were change in episodic learning and memory (B-SEVLT-Sum and SEVLT-Recall), language (word fluency [WF]), processing speed (Digit Symbol Substitution), and a cognitive impairment screener (Six-item...
#1Adam L. Boxer (UCSF: University of California, San Francisco)H-Index: 49
#2Michael HornbergerH-Index: 121
Last.Nadine TattonH-Index: 1
view all 31 authors...
Abstract Introduction Frontotemporal lobar degeneration (FTLD) is the most common form of dementia for those under 60 years of age. Increasing numbers of therapeutics targeting FTLD syndromes are being developed. Methods In March 2018, the Association for Frontotemporal Degeneration convened the Frontotemporal Degeneration Study Group meeting in Washington, DC, to discuss advances in the clinical science of FTLD. Results Challenges exist for conducting clinical trials in FTLD. Two of the greates...
#1Anna Antonell (University of Barcelona)H-Index: 20
#2Adria Tort (University of Barcelona)H-Index: 4
Last.Raquel Sánchez-Valle (University of Barcelona)H-Index: 34
view all 16 authors...
Abstract Introduction Synaptic damage, axonal neurodegeneration, and neuroinflammation are common features in Alzheimer's disease (AD), frontotemporal dementia (FTD), and Creutzfeldt-Jakob disease (CJD). Methods Unicentric cohort of 353 participants included healthy control (HC) subjects, AD continuum stages, genetic AD and FTD, and FTD and CJD. We measured cerebrospinal fluid neurofilament light (NF-L), neurogranin (Ng), 14-3-3, and YKL-40 proteins. Results Biomarkers showed differences in HC s...
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