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Jay Amin
University of Southampton
12Publications
4H-index
49Citations
Publications 12
Newest
#1B. M. S. McCausland (University Hospital Southampton NHS Foundation Trust)
#2H. P. Patel (University Hospital Southampton NHS Foundation Trust)
Last.V. C. Osman-Hicks (University Hospital Southampton NHS Foundation Trust)
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Background Specialist inpatient dementia units (SIDU) have been developed to address adverse outcomes often experienced by people living with dementia admitted to acute hospitals. However, the evidence base of their effectiveness remains limited.
#1Jay AminH-Index: 4
#2Delphine Boche (University of Southampton)H-Index: 24
Last.Sonja Rakic (University of Southampton)H-Index: 3
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The inflammasome complex is part of the innate immune system, which serves to protect the host against harm from pathogens and damaged cells. It is a term first proposed by Tschopp's group in 2002, with numerous original research articles and reviews published on the topic since. There have been many types of inflammasome identified, but all result in the common pathway of activation of caspases and interleukin 1? along with possible cell death due to pyroptosis. Despite a growing body of resear...
#1Jay Amin (University of Southampton)H-Index: 4
#2Claire Paquet (French Institute of Health and Medical Research)H-Index: 23
Last.Delphine Boche (University of Southampton)H-Index: 24
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Aims Active amyloid-β (Aβ) immunotherapy in Alzheimer's disease (AD) induces removal of Aβ and phosphorylated tau (ptau). Glycogen synthase kinase (GSK)-3β is a kinase, responsible for phosphorylation of tau, activation of which can be induced by phosphorylated double-stranded RNA-dependent protein kinase (pPKR). Using a post-mortem cohort of immunized AD cases, we investigated the effect of Aβ immunization on GSK-3β expression and pPKR. Methods We immunostained 11 immunized AD cases and 28 unim...
#1Claire Paquet (French Institute of Health and Medical Research)H-Index: 23
#2Jay Amin (University of Southampton)H-Index: 4
Last.Jacques Hugon (French Institute of Health and Medical Research)H-Index: 28
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Amyloid-beta peptide (Abeta) immunization of Alzheimer's disease (AD) patients has been reported to induce amyloid plaque removal, but with little impact on cognitive decline. We have explored the consequences of Abeta immunotherapy on neurons in post mortem brain tissue. Eleven immunized (AN1792, Elan Pharmaceuticals) AD patients were compared to 28 non-immunized AD cases. Immunohistochemistry on sections of neocortex was performed for neuron-specific nuclear antigen (NeuN), neurofilament prote...
#1Delphine Boche (University of Southampton)H-Index: 24
#2Jay Amin (University of Southampton)H-Index: 4
Last.Jacques Hugon (University of Paris)H-Index: 28
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May 1, 2010 in ATS (American Thoracic Society International Conference)
#1Howard Li (University of Colorado Denver)H-Index: 11
#2Amber Sorenson (University of Colorado Denver)H-Index: 1
Last.Raphael A. Nemenoff (University of Colorado Denver)H-Index: 42
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