Jay Amin
University Hospital Southampton NHS Foundation Trust
PathologyImmunologyDiseaseCancer researchBiology
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Publications 18
#1Jay AminH-Index: 4
#2Clive HolmesH-Index: 57
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Dataset supporting the thesis 'Inflammation in Dementia with Lewy bodies and Alzheimer’s disease' by Amin.Datasets from two studies: 1) Cerebral inflammation in Dementia with Lewy bodies (CIDL) - a human post-mortem study, and 2) Systemic inflammation in Dementia with Lewy bodies and Alzheimer's disease (SILAD) - an observational clinical study.
#2Peijun HeH-Index: 5
Last. Collin SonesH-Index: 18
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#1Rebecca Sussams (University of Southampton)H-Index: 3
#2Wolff SchlotzH-Index: 36
Last. Keeley J. Brookes (University of Nottingham)H-Index: 4
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To determine the relationship between psychological stress with cognitive outcomes in a multi-centre longitudinal study of people with amnestic mild cognitive impairment (aMCI) we assessed three parameters of psychological stress (Recent Life Changes Questionnaire (RLCQ); the Perceived Stress Scale (PSS) and salivary cortisol) and their relationship with rates of cognitive decline over an 18 month follow up period and conversion to dementia over a 5.5 year period. In 133 aMCI and 68 cognitively ...
#1L. Miles (University of Southampton)
#2B. M. S. McCausland (University of Southampton)
Last. V. C. Osman-Hicks (University of Southampton)
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Background The NHS dementia strategy identifies patient and carer information and support (PCIS) as a core component of gold-standard dementia care. This is the first systematic review of PCIS, performed to analyse the literature and evidence for these interventions.
#1B. M. S. McCausland (University Hospital Southampton NHS Foundation Trust)
#2H. P. Patel (University Hospital Southampton NHS Foundation Trust)
Last. V. C. Osman-Hicks (University Hospital Southampton NHS Foundation Trust)
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Background Specialist inpatient dementia units (SIDU) have been developed to address adverse outcomes often experienced by people living with dementia admitted to acute hospitals. However, the evidence base of their effectiveness remains limited.
#1Jay AminH-Index: 4
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia. However, the aetiology of DLB remains poorly understood in comparison with Alzheimer’s disease (AD) and Parkinson’s disease (PD). Current evidence supports that neuroinflammation, with involvement of the peripheral immune system, occurs in both AD and PD. Genetic studies in particular support an aetiological role for inflammation in AD rather than it being merely a consequence of neurodegeneration. Des...
#1Clive HolmesH-Index: 57
#2Rebecca SussamsH-Index: 3
Last. Jay AminH-Index: 4
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#1Jay AminH-Index: 4
Last. Delphine BocheH-Index: 25
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#1Jay AminH-Index: 4
#2Delphine Boche (University of Southampton)H-Index: 25
Last. Sonja Rakic (University of Southampton)H-Index: 3
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The inflammasome complex is part of the innate immune system, which serves to protect the host against harm from pathogens and damaged cells. It is a term first proposed by Tschopp's group in 2002, with numerous original research articles and reviews published on the topic since. There have been many types of inflammasome identified, but all result in the common pathway of activation of caspases and interleukin 1? along with possible cell death due to pyroptosis. Despite a growing body of resear...
9 CitationsSource
#1Jay Amin (University of Southampton)H-Index: 4
#2Claire Paquet (French Institute of Health and Medical Research)H-Index: 25
Last. Delphine Boche (University of Southampton)H-Index: 25
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Aims Active amyloid-β (Aβ) immunotherapy in Alzheimer's disease (AD) induces removal of Aβ and phosphorylated tau (ptau). Glycogen synthase kinase (GSK)-3β is a kinase, responsible for phosphorylation of tau, activation of which can be induced by phosphorylated double-stranded RNA-dependent protein kinase (pPKR). Using a post-mortem cohort of immunized AD cases, we investigated the effect of Aβ immunization on GSK-3β expression and pPKR. Methods We immunostained 11 immunized AD cases and 28 unim...
6 CitationsSource