Review paper
Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression
Abstract
Multiple studies have demonstrated elevations of α, β-unsaturated aldehydes including 4-hydroxynonenal (HNE) and acrolein, in vulnerable regions of mild cognitive impairment (MCI), preclinical Alzheimer's disease (PCAD), and late stage Alzheimer's disease (LAD) brain. However, there has been limited study of a third member, 4-hydroxyhexenal (HHE), a diffusible lipid peroxidation product of the ω-3 polyunstataturated fatty acids (PUFAs). In the...
Paper Details
Title
Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression
Published Date
Jun 1, 2012
Journal
Volume
33
Issue
6
Pages
1034 - 1044
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