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Non-destructive monitoring of creaming of oil-in-water emulsion-based formulations using magnetic resonance imaging

Published on Jul 1, 2014in Drug Development and Industrial Pharmacy2.367
· DOI :10.3109/03639045.2013.790903
Yoshinori Onuki15
Estimated H-index: 15
(Hoshi University),
Akihiro Horita2
Estimated H-index: 2
+ 3 AuthorsKozo Takayama47
Estimated H-index: 47
(Hoshi University)
Sources
Abstract
AbstractA non-destructive method for monitoring creaming of emulsion-based formulations is in great demand because it allows us to understand fully their instability mechanisms. This study was aimed at demonstrating the usefulness of magnetic resonance (MR) techniques, including MR imaging (MRI) and MR spectroscopy (MRS), for evaluating the physicochemical stability of emulsion-based formulations. Emulsions that are applicable as the base of practical skin creams were used as test samples. Substantial creaming was developed by centrifugation, which was then monitored by MRI. The creaming oil droplet layer and aqueous phase were clearly distinguished by quantitative MRI by measuring T1 and the apparent diffusion coefficient. Components in a selected volume in the emulsions could be analyzed using MRS. Then, model emulsions having different hydrophilic–lipophilic balance (HLB) values were tested, and the optimal HLB value for a stable dispersion was determined. In addition, the MRI examination enables the d...
  • References (35)
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This study investigated the relationship between the state of water and the dispersion stability of a skin cream formulation. Hydrophilic ointments treated with a high-pressure wet-type jet mill were used as model formulations. Spin–lattice relaxation times (T1) were measured by magnetic resonance techniques to estimate the state of water in samples. A shorter T1 relaxation time was obtained from samples with higher surfactant content, whereas the processing pressure of the jet mill and 1-week s...
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