Akihiro Horita
ViscosityCreamingChemistryDispersion stabilityEmulsion
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Publications 2
#1Yoshinori Onuki (Hoshi University)H-Index: 15
#2Naoki Hasegawa (Hoshi University)H-Index: 2
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 8 authors...
The physical stability of pharmaceutical emulsions is an important quality attribute to be considered. To obtain a better understanding of this issue, this study investigated the contribution of the state of water to the physical stability of pharmaceutical emulsions. The key technology to evaluate the state of water was magnetic resonance imaging (MRI). For sample preparation, model emulsions with different formulation variables (surfactant content, water content, and hydrophilic-lipophilic bal...
4 CitationsSource
#1Yoshinori Onuki (Hoshi University)H-Index: 15
#2Akihiro HoritaH-Index: 2
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 6 authors...
AbstractA non-destructive method for monitoring creaming of emulsion-based formulations is in great demand because it allows us to understand fully their instability mechanisms. This study was aimed at demonstrating the usefulness of magnetic resonance (MR) techniques, including MR imaging (MRI) and MR spectroscopy (MRS), for evaluating the physicochemical stability of emulsion-based formulations. Emulsions that are applicable as the base of practical skin creams were used as test samples. Subst...
5 CitationsSource