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Drug Development and Industrial Pharmacy
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#1Marzieh Gandomkarzadeh (Shahid Beheshti University of Medical Sciences and Health Services)
#2Arash Mahboubi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 8
Last. Hamid Moghimi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 18
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Objective To evaluate the effect of ciprofloxacin concentration and cement geometry on release, mechanical and antibacterial properties of PMMA bone cement.Significance Cements are used in different geometries and drug concentrations. These can affect cement strength, drug release behavior and its antibacterial activity.Methods Antibiotic-loaded bone cement (ALBC) containing 2.5, 5.0 and 10.0 wt% ciprofloxacin were prepared as slab, rectangular prism and short cylinder. Drug release and compress...
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#1Christi A. Wilkins (NWU: North-West University)
#2Lissinda H. du Plessis (NWU: North-West University)H-Index: 16
Last. Joe M. Viljoen (NWU: North-West University)H-Index: 5
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Objective: The World Health Organization has called for the development of novel drug delivery systems to combat malaria - the fourth most prevalent cause of death globally. The plausibility of utilizing hot fusion to prepare solid lipid dispersions containing the prescribed first-line, double-fixed dose combination (artemether and lumefantrine), proposed for inclusion in directly compressed lipid matrix tablets, was investigated.Significance: Currently, no anti-malarial product is commercially ...
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#1Nazafarin Satari (IUMS: Isfahan University of Medical Sciences)
#2Somayeh Taymouri (IUMS: Isfahan University of Medical Sciences)H-Index: 8
Last. Mina Mirian (IUMS: Isfahan University of Medical Sciences)H-Index: 8
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Gefitinib as an epidermal growth factor receptor tyrosine kinase inhibitor has strong potential in lung cancer therapy. However, a major challenge of using gefitinib is its toxicities. In the present study, we developed a dry powder inhaler dosage form containing gefitinib loaded glucosamine targeted solid lipid nanopaticles (Gef-G-SLNs) to locally transfer anticancer agent to the lung tumor. The Gef-G-SLNs were prepared by emulsion-solvent diffusion and evaporation method and optimized with irr...
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#2Dina S. El-Kafrawy (Alexandria University)H-Index: 4
Last. Tarek S. Belal (Alexandria University)H-Index: 16
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A stability-indicating high performance liquid chromatography method with diode array detection (HPLC-DAD) was developed and validated for simultaneous determination of phenylephrine hydrochloride ...
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Solid-state compatibility of API with excipients is essential step in the preformulation stage of early development of new finished dosage form. Thermal analysis and vibrational spectroscopy are complementary techniques that play pivotal role to assess the solid-state compatibility of API with excipients. Their coupling and combination with multivariate analysis, provide valuable quantitative aspect to reveal the potential interactions. The impetus of this work was aimed to fully elucidate the s...
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#1Valentina Petruševska (Pliva (Croatia))
#2Kornelija Lasić (Pliva (Croatia))H-Index: 1
Last. Ana Mornar (University of Zagreb)H-Index: 13
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The compatibility of formulation components is crucial for safe and high-quality medicines. To detect the potential for incompatibility and to assess formulation stability it is beneficial to conduct compatibility study during the drug development phase. The therapy of tuberculosis normally consists of two or more medicines taken together. Consequently, different antituberculotic fixed-dose combination (FDC) formulations have been developed. Isoniazid is first-line medicine and present in severa...
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#1Chun Y. Wong (Curtin University)H-Index: 5
#2Jorge Martinez (Curtin University)H-Index: 6
Last. Crispin R. Dass (Curtin University)H-Index: 46
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Introduction: Therapeutic peptides are administered via parenteral route due to poor absorption in the gastrointestinal (GI) tract, instability in gastric acid and GI enzymes. Polymeric drug delive...
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#1Georgios K. Eleftheriadis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 6
#2Christos S. Katsiotis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 1
Last. Dimitrios G. Fatouros (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 24
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Objective: The inkjet printing (IP) and fused deposition modeling (FDM) technologies have emerged in the pharmaceutical field as novel and personalized formulation approaches. Specific manufacturing factors must be considered in each adopted methodology, i.e., the development of suitable substrates for IP and the incorporation of highly thermostable active pharmaceutical compounds (APIs) for FDM. In this study, IP and FDM printing technologies were investigated for the fabrication of hydroxyprop...
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#1Anastasia Foppoli (University of Milan)H-Index: 16
#2Matteo Cerea (University of Milan)H-Index: 12
Last. Andrea Gazzaniga (University of Milan)H-Index: 35
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A swellable/erodible system for oral time-dependent release, demonstrated to provide consistent pulsatile and colonic delivery performance, has been manufactured through a range of coating techniques to achieve the functional hydroxypropyl methylcellulose (HPMC) layer. Although aqueous spray-coating has long been preferred, the processing times and yields still represent open issues, especially in view of the considerable amount of polymer required to give in vivo lag phases of proper duration. ...
1 CitationsSource
#1Laís F. Azevedo de M. Oliveira (UFAL: Federal University of Alagoas)H-Index: 1
#2Laís Vanessa Teles Azevedo (UFAL: Federal University of Alagoas)
Last. Eduardo J. S. Fonseca (UFAL: Federal University of Alagoas)H-Index: 16
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This work brings the promise of MCM-41 mesoporous silica as a vehicle for red propolis for the development of controlled release drugs and delivery to a specific target site. The synthesis of MCM-4...
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