Drug Development and Industrial Pharmacy
Papers 6282
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#1Patrick Strack (LMU: Ludwig Maximilian University of Munich)
#2Raimund Külzer (Boehringer Ingelheim)H-Index: 1
Last. Achim Grube (Boehringer Ingelheim)
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Objective: Validation of a prospective new therapeutic concept in a proof of concept study is costly and time-consuming. In particular, pharmacologically active tool compounds often lack suitable pharmacokinetic (PK) properties for subsequent studies. The current work describes a PLGA-based formulation platform, encapsulating different preclinical research compounds into extended release microparticles, to optimize their PK properties after subcutaneous administration.Significance: Developing a ...
#1Ting-Ting Yan (Guangdong Pharmaceutical University)
#2Zhufen Lv (Guangdong Pharmaceutical University)H-Index: 3
Last. Yanzhong Chen (Guangdong Pharmaceutical University)H-Index: 3
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AbstractOrodispersible films (ODFs) are promising drug delivery systems for customized medicines as it provide an alternative approach to increase consumer acceptance by advantages of rapid dissolu...
#1Ming Jing (LNUTCM: Liaoning University of Traditional Chinese Medicine)
Last. Si‐yu He (LNUTCM: Liaoning University of Traditional Chinese Medicine)
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As a malignant tumor, breast cancer is very prone to metastasis. Chemotherapy is one of the most common means for treating breast cancer. However, due to the serious metastasis and the poor targeting effect of traditional chemotherapeutic drugs, even after years of efforts, the therapeutic effect is still unsatisfied. Therefore, in this study, we constructed a kind of PFV modified epirubicin plus schisandrin B liposomes to solve the above disadvantages. In vitro experiments showed that the targe...
#1Dinesh Suram (Kakatiya University)H-Index: 1
#2Arjun Narala (Kakatiya University)H-Index: 2
Last. Kishan Veerabrahma (Kakatiya University)H-Index: 9
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Abstract:Iloperidone (ILO) is an anti-psychotic, used in schizophrenia. It has low bioavailability (36%) due to low solubility and first pass effect. Oral solid self microemulsifying drug delivery ...
#1Dipanjoy Ghosh (LPU: Lovely Professional University)H-Index: 1
#2Sachin Kumar Singh (LPU: Lovely Professional University)H-Index: 10
Last. Ankit Awasthi (LPU: Lovely Professional University)H-Index: 1
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AbstractDevelopment of self-nanoemulsifying drug delivery systems (SNEDDS) of docosahexaenoic acid (DHA) is reported with the aim to achieve enhanced dissolution rate. The optimized composition of ...
#1Adejumoke Lara Ajiboye (University of Greenwich)H-Index: 1
#2Vivek Trivedi (Medway School of Pharmacy)H-Index: 9
Last. John C. Mitchell (University of Greenwich)H-Index: 30
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AbstractThe adsorption of γ-globulin was evaluated with experiments with silica particles marketed as Syloid AL1-FP (SAL), XDP-3150 (SXDP), and 244FP (SFP). The influence of pH, pore sizes, and deg...
#1Turki Al Hagbani (ULM: University of Louisiana at Monroe)H-Index: 2
#2Mohammad M. Kamal (ULM: University of Louisiana at Monroe)H-Index: 3
Last. Sami Nazzal (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 22
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AbstractObjective: Developing chewing gum tablets (CGTs) with high drug loads is a challenge due to the loss of mastication properties. We postulated that poor mastication properties of such gums c...
#2Ali Shirani (Tabriz University of Medical Sciences)H-Index: 3
#3Ali Nokhodchi (University of Sussex)H-Index: 43
Last. Hadi Valizadeh (Tabriz University of Medical Sciences)H-Index: 29
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The low cellular uptake of Methotrexate (MTX), a commonly used anticancer drug, is a big challenge for efficient cancer therapy. Self-assembled peptide nanoparticles (SAPNs) are one of the ...
#1Huixin Li (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Sirun Lu (SPU: Shenyang Pharmaceutical University)
Last. Tianhong Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 11
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AbstractRaloxifene hydrochloride (RH) suffers from low oral bioavailability due to its low water-solubility and first-pass metabolism. Therefore, a novel phospholipid complex of RH (RHPC) and a mat...
#1Hanna Kotlowska (Gdańsk Medical University)
Last. Buchi N. NalluriH-Index: 6
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AbstractObjective: The purpose of this study was to apply the rheological measurements to assess the flow properties of powders and granules and to compare the results with the standard pharmacopei...
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