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Kozo Takayama
Josai University
380Publications
47H-index
8,002Citations
Publications 375
Newest
#1Takuya Oishi (University of Toyama)H-Index: 1
#2Yoshihiro Hayashi (University of Toyama)H-Index: 7
Last.Yoshinori Onuki (University of Toyama)H-Index: 15
view all 8 authors...
Abstract Our aim was to understand better the causal relationships between material attributes (MAs), process parameters (PPs), and critical quality attributes (CQAs) using an originally created large dataset and regularized linear regression models. In this study, we focused on the following three points: (1) creation of a dataset comprising several tablet production methods, (2) the influence of interaction terms of MAs and/or PPs, and (3) comparison of regularized linear regression models wit...
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#1Keisuke Takagaki (Hoshi University)H-Index: 2
#2Terushi Ito (University of Toyama)
Last.Yoshinori Onuki (University of Toyama)H-Index: 15
view all 6 authors...
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#1Pratyusa Sahoo (UM: University of Malaya)H-Index: 1
#2Kok Hoong Leong (UM: University of Malaya)H-Index: 10
Last.Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 6 authors...
Abstract We previously reported that insulin-entrapped chitosan complexed carboxymethylated iota-carrageenan (CS/CMCi) particles exhibit pH-responsive swelling behavior. However, the particles’ stability in the enzymatic gastrointestinal environment, their drug permeability mechanism, and related in vivo studies have not been discussed to date. In this study, we investigated the stability, muco-adhesiveness, transport mechanism and in vivo assessment of the particles. The particles retained thei...
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#1Kozo Takayama (Hoshi University)H-Index: 47
#2Tsubasa Sato (Hoshi University)
Last.Kenji Sugibayashi (Josai University)H-Index: 5
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Abstract Effects of residual stresses on the mechanical characteristics of tablets such as tensile strength (TS) and disintegration time (DT) were investigated. The residual stresses were simulated using the finite element method (FEM), in which the powder compaction was represented by a Drucker-Prager cap (DPC) model under unconstrained condition. As model tablet formulations, we employed powder mixtures comprising various quantities of lactose (LAC), corn starch (CS), and microcrystalline cell...
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#1Takahiro Tsuji (University of Toyama)H-Index: 1
#2Koji Mochizuki (Hoshi University)
Last.Yoshinori Onuki (University of Toyama)H-Index: 15
view all 7 authors...
Abstract The time–temperature superposition principle (TTSP) was applied to the destabilization kinetics of a pharmaceutical emulsion. The final goal of this study is to predict precisely the emulsion stability after long-term storage from the short-period accelerated test using TTSP. As the model emulsion, a cream preparation that is clinically used for the treatment of pruritus associated with chronic kidney disease was tested. After storage at high temperatures ranging from 30 to 45 °C for de...
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#1Yoshihiro Hayashi (University of Toyama)H-Index: 7
#2Yuki Marumo (University of Toyama)H-Index: 2
Last.Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
Abstract The purpose of this study was to explore the potential of a quantitative structure–property relationship (QSPR) model to predict tablet density. First, we calculated 3381 molecular descriptors for 81 active pharmaceutical ingredients (API). Second, we obtained data that were merged with a dataset including powder properties that we had constructed previously. Next, we prepared 81 types of tablet, each containing API, microcrystalline cellulose, and magnesium stearate using direct compre...
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#1Terushi Ito (University of Toyama)
#2Chihiro Kida (Hoshi University)H-Index: 3
Last.Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
The purpose of the present study is to demonstrate the applicability of magnetic resonance imaging, especially T2 relaxation time mapping, for nondestructive monitoring of the dispersion state of nanoparticles (NPs) in concentrated suspensions. TiO2 15-nm-diameter NPs, for use in sunscreen lotion products, were examined as a test NP. First, this study investigated whether T2 is sensitive to the NP concentration. In experiments with pulsed nuclear magnetic resonance on TiO2 NP suspensions with di...
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#1Hiroaki Todo (Josai University)H-Index: 14
#2Mai Tamura (Josai University)
Last.Kenji Sugibayashi (Josai University)H-Index: 36
view all 9 authors...
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#1Yoshihiro Hayashi (University of Toyama)H-Index: 7
#2Takuya Oishi (University of Toyama)H-Index: 1
Last.Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
AbstractObjectives: The aim of this study was to explore the potential of boosted tree (BT) to develop a correlation model between active pharmaceutical ingredient (API) characteristics and a tensile strength (TS) of tablets as critical quality attributes.Methods: First, we evaluated 81 kinds of API characteristics, such as particle size distribution, bulk density, tapped density, Hausner ratio, moisture content, elastic recovery, molecular weight, and partition coefficient. Next, we prepared ta...
4 CitationsSource
#1Hiroaki Todo (Josai University)H-Index: 14
#2Kazuki Sato (Josai University)H-Index: 1
Last.Kenji Sugibayashi (Josai University)H-Index: 36
view all 4 authors...
Direct compression is a popular choice as it provides the simplest way to prepare the tablet. It can be easily adopted when the active pharmaceutical ingredient (API) is unstable in water or to thermal drying. An optimal formulation of preliminary mixed powders (premix powders) is beneficial if prepared in advance for tableting use. The aim of this study was to find the optimal formulation of the premix powders composed of lactose (LAC), cornstarch (CS), and microcrystalline cellulose (MCC) by u...
1 CitationsSource
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