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Yoshinori Onuki
University of Toyama
Organic chemistryChemistryInsulinChromatographyBiochemistry
88Publications
15H-index
1,032Citations
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Publications 90
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#1Takuya Oishi (University of Toyama)H-Index: 1
#2Yoshihiro Hayashi (University of Toyama)H-Index: 7
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 8 authors...
Abstract Our aim was to understand better the causal relationships between material attributes (MAs), process parameters (PPs), and critical quality attributes (CQAs) using an originally created large dataset and regularized linear regression models. In this study, we focused on the following three points: (1) creation of a dataset comprising several tablet production methods, (2) the influence of interaction terms of MAs and/or PPs, and (3) comparison of regularized linear regression models wit...
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#1Keisuke Takagaki (Hoshi University)H-Index: 2
#2Terushi Ito (University of Toyama)
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 6 authors...
1 CitationsSource
#1Pratyusa Sahoo (UM: University of Malaya)H-Index: 1
#2Kok Hoong Leong (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
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Abstract We previously reported that insulin-entrapped chitosan complexed carboxymethylated iota-carrageenan (CS/CMCi) particles exhibit pH-responsive swelling behavior. However, the particles’ stability in the enzymatic gastrointestinal environment, their drug permeability mechanism, and related in vivo studies have not been discussed to date. In this study, we investigated the stability, muco-adhesiveness, transport mechanism and in vivo assessment of the particles. The particles retained thei...
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#2Yoshihisa Yamamoto (Teikyo Heisei University)H-Index: 5
Last. Toshiro Fukami (Meiji Pharmaceutical University)H-Index: 13
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We demonstrated the difference in the distribution state of pharmaceutical ingredients between tacrolimus (TCR) original ointment and six kinds of generic medicines. Two-dimensional imaging and dep...
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#1Kotaro Okada (University of Toyama)H-Index: 1
#2Daijiro HiraiH-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 6 authors...
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#1Takahiro Tsuji (University of Toyama)H-Index: 1
#2Koji Mochizuki (Hoshi University)
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
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Abstract The time–temperature superposition principle (TTSP) was applied to the destabilization kinetics of a pharmaceutical emulsion. The final goal of this study is to predict precisely the emulsion stability after long-term storage from the short-period accelerated test using TTSP. As the model emulsion, a cream preparation that is clinically used for the treatment of pruritus associated with chronic kidney disease was tested. After storage at high temperatures ranging from 30 to 45 °C for de...
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#1Yoshihiro Hayashi (University of Toyama)H-Index: 7
#2Yuki Marumo (University of Toyama)H-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
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Abstract The purpose of this study was to explore the potential of a quantitative structure–property relationship (QSPR) model to predict tablet density. First, we calculated 3381 molecular descriptors for 81 active pharmaceutical ingredients (API). Second, we obtained data that were merged with a dataset including powder properties that we had constructed previously. Next, we prepared 81 types of tablet, each containing API, microcrystalline cellulose, and magnesium stearate using direct compre...
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#1Terushi Ito (University of Toyama)
#2Kotaro Okada (University of Toyama)H-Index: 1
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 8 authors...
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#1Kotaro Okada (University of Toyama)H-Index: 1
#2Daijiro HiraiH-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 6 authors...
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