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Yoshinori Onuki
University of Toyama
Organic chemistryChemistryInsulinChromatographyBiochemistry
88Publications
15H-index
1,032Citations
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Publications 92
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#1Kotaro Okada (University of Toyama)H-Index: 1
#2Yoshihiro HayashiH-Index: 7
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 4 authors...
Abstract We sought to demonstrate the usefulness of the T2 relaxation behaviors measured by time domain NMR (TD-NMR) for the quantitative evaluation of the crystallinity of an active pharmaceutical ingredient (API). This study used indomethacin as a model API. After blending amorphous and crystalline indomethacin powders at a designated ratio, T2 relaxation curves were measured by TD-NMR. Subsequently, we acquired a calibration curve to quantify crystallinity by curve fitting analysis. Validatio...
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#1Atsushi KosugiH-Index: 2
#2Kok Hoong Leong (UM: University of Malaya)H-Index: 10
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 7 authors...
Abstract The purpose of this study was to accumulate enhanced technical knowledge about the powder properties of direct compaction grades of mannitol that could lead to new tablet formulations. Fifteen different commercial direct compaction grades of mannitol were tested. Ten different powder properties representing flowability, particle size, specific surface area and manufacturing properties were measured. In addition, model tablets of each mannitol grade were prepared, and their disintegratio...
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Background: The clobetasol propionate cream formulations (CLB Cr ) belong to the "strongest" group, and are used widely. In addition, those formulations are often used as a mixture with moisturizer. Recently, we evaluated pharmaceutical properties of the CLB Cr using near infrared (NIR) spectroscopy, and characteristic NIR spectra depending on the formulation were observed. In the present study, we attempted to evaluate the more diverse pharmaceutical properties of CLB Cr , including the stabili...
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#1Takuya Oishi (University of Toyama)H-Index: 1
#2Yoshihiro Hayashi (University of Toyama)H-Index: 7
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 8 authors...
Abstract Our aim was to understand better the causal relationships between material attributes (MAs), process parameters (PPs), and critical quality attributes (CQAs) using an originally created large dataset and regularized linear regression models. In this study, we focused on the following three points: (1) creation of a dataset comprising several tablet production methods, (2) the influence of interaction terms of MAs and/or PPs, and (3) comparison of regularized linear regression models wit...
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#1Keisuke Takagaki (Hoshi University)H-Index: 2
#2Terushi Ito (University of Toyama)
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 6 authors...
1 CitationsSource
#2Yoshihisa Yamamoto (Teikyo Heisei University)H-Index: 5
Last. Toshiro Fukami (Meiji Pharmaceutical University)H-Index: 13
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We demonstrated the difference in the distribution state of pharmaceutical ingredients between tacrolimus (TCR) original ointment and six kinds of generic medicines. Two-dimensional imaging and dep...
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#1Pratyusa Sahoo (UM: University of Malaya)H-Index: 1
#2Kok Hoong Leong (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
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Abstract We previously reported that insulin-entrapped chitosan complexed carboxymethylated iota-carrageenan (CS/CMCi) particles exhibit pH-responsive swelling behavior. However, the particles’ stability in the enzymatic gastrointestinal environment, their drug permeability mechanism, and related in vivo studies have not been discussed to date. In this study, we investigated the stability, muco-adhesiveness, transport mechanism and in vivo assessment of the particles. The particles retained thei...
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#1Kotaro Okada (University of Toyama)H-Index: 1
#2Daijiro HiraiH-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 6 authors...
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#1Takahiro Tsuji (University of Toyama)H-Index: 1
#2Koji Mochizuki (Hoshi University)
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 7 authors...
Abstract The time–temperature superposition principle (TTSP) was applied to the destabilization kinetics of a pharmaceutical emulsion. The final goal of this study is to predict precisely the emulsion stability after long-term storage from the short-period accelerated test using TTSP. As the model emulsion, a cream preparation that is clinically used for the treatment of pruritus associated with chronic kidney disease was tested. After storage at high temperatures ranging from 30 to 45 °C for de...
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#1Yoshihiro Hayashi (University of Toyama)H-Index: 7
#2Yuki Marumo (University of Toyama)H-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
Abstract The purpose of this study was to explore the potential of a quantitative structure–property relationship (QSPR) model to predict tablet density. First, we calculated 3381 molecular descriptors for 81 active pharmaceutical ingredients (API). Second, we obtained data that were merged with a dataset including powder properties that we had constructed previously. Next, we prepared 81 types of tablet, each containing API, microcrystalline cellulose, and magnesium stearate using direct compre...
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