Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression

To investigate the role of hippocampal plasticity in the antidepressant effect of electroconvulsive therapy (ECT).We used magnetic resonance (MR) imaging including diffusion tensor imaging (DTI) and proton MR spectroscopy (1 H-MRS) to investigate hippocampal volume, diffusivity, and metabolite changes in 19 patients receiving ECT for severe depression. Other regions of interest included the amygdala, dorsolateral prefrontal cortex (DLPFC),...