Acute Kidney Injury in a Young Patient with Severe Malaria: A Case Report

Danny A. Milner Jr. Harvard T.H. Chan School of Public Health, American Society for Clinical Pathology, Center for Global Health, Chicago, Illinois 60603 Correspondence: dmilner{at}ascp.org

Malaria is an Italian word composed of “ mala ” and “ aria,” derived from malus (bad), and aeris (air). It was first used to describe a fever (miasma), which was wrongly attributed to exposure to poisonous air rising from marshes. Although the disease had been described in the Hippocratic Collection (460 to 377 BC) and its relation to mosquitoes suggested in the 5th century AD, by the Indian physician Susruta, it was only in 1880 that Charles Laveran, a French physician working in Algeria, disco...

Malaria is a major public health problem in tropical countries. About 500 million people suffer from malaria, leading to death in 1 to 3 million cases. Acute kidney injury (AKI) is one of the most dreaded complications of severe malaria. As per World Health Organization criteria, acute renal failure (serum creatinine level, > or =3 mg/dL or > or =265 micromol/L) occurs as a complication of Plasmodium falciparum malaria in less than 1% of cases, but the mortality rate in these cases may be up to ...

Summary Objective To use electron microscopy to examine the role of parasitized red blood cell (PRBC) sequestration in the pathogenesis of acute renal failure in severe falciparum malaria. Methods Ultrastructural pathological examination of renal tissues from Southeast Asian adults ( n = 63) who died from severe falciparum malaria. Qualitative and quantitative determination of the major pathological features of disease, including PRBC and leukocyte sequestration. Clinico‐pathological correlation...

Important strides have been made within the past decade toward malaria elimination in many regions, and with this progress, the feasibility of eradication is once again under discussion. If the ambitious goal of eradication is to be achieved by 2040, all species of

According to current estimates, Plasmodium malariae is not very common in Senegal, as more than 98% of malaria cases are suspected to be due to Plasmodium falciparum. However, it is possible that other malarial species are being under-reported or misdiagnosed. This is a report of a case of P. malariae in a 30-year-old man previously hospitalized with acute kidney injury after treatment with quinine and re-hospitalized three months later. He was diagnosed with renal cortical necrosis post malaria...

Acute renal failure (ARF) is a common cause of morbidity and mortality in severe malaria infection. We evaluated factors associated with acute renal failure in severe malaria by comparing patients with severe malaria with and without ARF admitted to the Hospital for Tropical Diseases, Bangkok, Thailand. Nine hundred fifteen severe malaria patients were included in the study, of whom 195 had ARF and 720 did not have ARF. We found jaundice, anemia, hypoalbuminemia, hyponatremia, hyperkalemia, acid...

Acute renal failure (ARF) secondary to severe malaria is uncommon. We report a case of a patient visiting Africa for the first time presenting with malaria and ARF. There was complete recovery after hemodialysis. Early initiation of hemodialysis proves to be useful in restoration of renal function.

We report two cases of severe malaria who presented with non-specific clinical features. One of the casesis a 50 year old female who was brought to our hospital with high grade fever and severe abdominal pain,whereas the other case was a 20 year old male presented with high grade fever and headache. Both thecases presented with abnormal liver and renal function tests. P.malariae and P.falciparum are responsiblefor clinically important renal disease the former causes chronic progressive syndrome ...

Malaria transmitted mainly by mosquito vectors (female Anopheles species) is one of the leading causes of death from infectious diseases in the world.In the fight against malaria, some countries have achieved elimination success with national health policies.However, the efforts of national organizations in the fight against malaria are insufficient in low-income countries and the support of international organizations is needed as a part of the global malaria struggle.Somalia is an easternmost ...