Journal of The American Society of Nephrology
Papers 9725
1 page of 973 pages (9,725 results)
#1Richard Corbett (Imperial College Healthcare)H-Index: 6
#2Sarah Blakey (Imperial College Healthcare)H-Index: 1
view all 8 authors...
BACKGROUND: During the coronavirus disease 2019 (COVID-19) epidemic, many countries have instituted population-wide measures for social distancing. The requirement of patients on dialysis for regular treatment in settings typically not conducive to social distancing may increase their vulnerability to COVID-19. METHODS: Over a 6-week period, we recorded new COVID-19 infections and outcomes for all adult patients receiving dialysis in a large dialysis center. Rapidly introduced control measures i...
#1Huijuan Wu (Fudan University)H-Index: 8
Last. T. Sandow (Ochsner Health System)H-Index: 2
view all 17 authors...
BACKGROUND: Kidney involvement is a feature of COVID-19 and it can be severe in black patients. Previous research linked increased susceptibility to collapsing glomerulopathy, including in patients with HIV-associated nephropathy, to apo L1 (APOL1) variants that are more common in those of African descent. METHODS: To investigate genetic, histopathologic, and molecular features in six black patients with COVID-19 presenting with AKI and de novo nephrotic-range proteinuria, we obtained biopsied k...
#1Nidhi Dwivedi (KU: University of Kansas)
#2Shi-Xin Tao (KU: University of Kansas)H-Index: 11
Last. Reena Rao (KU: University of Kansas)H-Index: 17
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Background Fibrosis is a major cause of loss of renal function in autosomal dominant polycystic kidney disease (ADPKD). In this study, we examined whether vasopressin type-2 receptor (V2R) activity in cystic epithelial cells can stimulate interstitial myofibroblasts and fibrosis in ADPKD kidneys. Methods We treated Pkd1 gene knockout (Pkd1KO) mice with dDAVP, a V2R agonist, for 3 days and evaluated the effect on myofibroblast deposition of extracellular matrix (ECM). We also analyzed the effects...
#1Didier Collard (UvA: University of Amsterdam)H-Index: 1
#2Peter M. van Brussel (UvA: University of Amsterdam)H-Index: 3
Last. R. J. de Winter (UvA: University of Amsterdam)H-Index: 56
view all 11 authors...
BACKGROUND Glomerular hyperfiltration resulting from an elevated intraglomerular pressure (Pglom) is an important cause of CKD, but there is no feasible method to directly assess Pglom in humans. We developed a model to estimate Pglom in patients from combined renal arterial pressure and flow measurements. METHODS We performed hemodynamic measurements in 34 patients undergoing renal or cardiac angiography under baseline conditions and during hyperemia induced by intrarenal dopamine infusion (30 ...
#1Thomas H. Hostetter (UNC: University of North Carolina at Chapel Hill)H-Index: 1
#1Osama El Shamy (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
#2Niralee Patel (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
Last. Jaime Uribarri (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 44
view all 10 authors...
#1Di Feng (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
#2Mukesh Kumar (Boston Children's Hospital)
Last. Johannes Schlondorff (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 19
view all 18 authors...
BACKGROUND Genetic mutations in α-actinin-4 (ACTN4)-an important actin crosslinking cytoskeletal protein that provides structural support for kidney podocytes-have been linked to proteinuric glomerulosclerosis in humans. However, the effect of post-translational modifications of ACTN4 on podocyte integrity and kidney function is not known. METHODS Using mass spectrometry, we found that ACTN4 is phosphorylated at serine (S) 159 in human podocytes. We used phosphomimetic and nonphosphorylatable AC...
#1Jing-Fu Bao (Southern Medical University)
#2Pan-Pan Hu (Southern Medical University)
Last. Aiqing Li (Southern Medical University)H-Index: 3
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Cardiac hypertrophy is a common feature in patients with CKD. Recent studies revealed that two phosphate regulators, fibroblast growth factor-23 and α-Klotho, are highly involved in the pathophysiologic process of CKD-induced cardiac hypertrophy. With decreasing renal function, elevated fibroblast growth factor-23 and decreased α-Klotho may contribute to cardiac hypertrophy by targeting the heart directly or by inducing systemic changes, such as vascular injury, hemodynamic disorders, and inflam...
#1M. BobotH-Index: 1
#2Laurent Thomas (CNRS: Centre national de la recherche scientifique)H-Index: 9
Last. Stephane Poitevin (French Institute of Health and Medical Research)H-Index: 1
view all 16 authors...
BACKGROUND Uremic toxicity may play a role in the elevated risk of developing cognitive impairment found among patients with CKD. Some uremic toxins, like indoxyl sulfate, are agonists of the transcription factor aryl hydrocarbon receptor (AhR), which is widely expressed in the central nervous system and which we previously identified as the receptor of indoxyl sulfate in endothelial cells. METHODS To characterize involvement of uremic toxins in cerebral and neurobehavioral abnormalities in thre...
#1Melanie P. Hoenig (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 7
#2Theodore I. Steinman (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 37
Last. Mark L. Zeidel (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 52
view all 4 authors...
Top fields of study
Kidney disease
Diabetes mellitus