Biomarkers in Down syndrome can help us understand Alzheimer's disease

Down syndrome is associated with increased risk of developing early-onset Alzheimer's disease, primarily because of the overexpression of the APP gene on chromosome 21. People with Down syndrome, as a form of genetically determined Alzheimer's disease, represent one of the largest cohorts at risk of early-onset Alzheimer's disease because virtually all adults with Down syndrome will develop Alzheimer's disease by age 40 years. 1 Lott IT Head E...