Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease

Genetic studies of Alzheimer disease have focused on the clinical or pathologic diagnosis as the primary outcome, but little is known about the genetic basis of the preclinical phase of the disease.To examine the underlying genetic basis for brain amyloidosis in the preclinical phase of Alzheimer disease.In the first stage of this genetic association study, a meta-analysis was conducted using genetic and imaging data acquired from 6 multicenter...