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Richard Mayeux
Columbia University Medical Center
PsychologyDiseaseDementiaAlzheimer's diseaseMedicine
841Publications
130H-index
66.2kCitations
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Publications 839
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#1Jose GutierrezH-Index: 20
Last. Richard MayeuxH-Index: 130
view all 6 authors...
Background: Cerebral hemodynamic dysfunction is associated with brain small artery disease and poorer cognition. With aging, systemic arteries stiffen, magnifying the spread of pulsatility to dista...
#1Logan Dumitrescu (VUMC: Vanderbilt University Medical Center)H-Index: 5
#2Emily R. Mahoney (VUMC: Vanderbilt University Medical Center)H-Index: 1
Last. Jesse Mez (BU: Boston University)H-Index: 7
view all 49 authors...
Approximately 30% of older adults exhibit the neuropathologic features of Alzheimer9s disease (AD) without signs of cognitive impairment. Yet, little is known about the genetic factors that allow these potentially resilient individuals to remain cognitively normal in the face of substantial neuropathology. We performed a large, genome-wide association study (GWAS) of two previously validated metrics of cognitive resilience quantified using a latent variable modeling approach and representing bet...
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#1Eric M. ReimanH-Index: 97
#2Joseph F. Arboleda-Velasquez (Harvard University)H-Index: 13
Last. John Hardy (UCL Institute of Neurology)H-Index: 152
view all 42 authors...
Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer’s dementia, while the APOE2 allele is associated with a lower risk of Alzheimer’s dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk. We generated Alzheimer’s dementia odds ratios and other findings in more than 5,000 clinically characterized and neuropathologically characterized Alzheimer’s dementia cases and controls. APOE2/2 was associated with a low Alz...
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#1Davangere P. Devanand (CUMC: Columbia University Medical Center)H-Index: 3
#2Seonjoo Lee (Columbia University)H-Index: 16
Last. Richard Mayeux (Columbia University)H-Index: 130
view all 11 authors...
Abstract Introduction Odor identification deficits characterize Alzheimer's disease and other dementias. We examined if intact performance on brief cognitive and odor identification tests predicts lack of transition to dementia. Methods In an urban community, 1037 older adults without dementia completed the 40-item University of Pennsylvania Smell Identification Test, which includes the 12-item Brief Smell Identification Test (B-SIT). Data from 749 participants followed up for 4 years were analy...
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#1Badri N. Vardarajan (Columbia University)H-Index: 28
#2Vrinda Kalia (Columbia University)H-Index: 3
Last. Richard Mayeux (Columbia University)H-Index: 130
view all 10 authors...
Importance. Metabolomics can provide insight into molecular mechanisms within biochemical pathways leading to disease or in vivo changes that result from the disease. Objective. The goal of this investigation was to identify metabolites in plasma that capture systemic biochemical changes associated with Alzheimer disease (AD). Design. Plasma from individuals in a multi-ethnic, community-based cohort study underwent untargeted liquid chromatography (LC)-based ultra-high resolution mass spectromet...
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#1Erin R. Kulick (Columbia University)H-Index: 4
#1Erin R Kulick (Brown University)
Last. Gregory A. Wellenius (Brown University)H-Index: 36
view all 9 authors...
Abstract Background There is mounting evidence that long-term exposure to air pollution is related to accelerated cognitive decline in aging populations. Factors that influence individual susceptibility remain largely unknown, but may involve the apolipoprotein E genotype E4 (APOE-e4) allele. Objectives We assessed whether the association between long-term exposure to ambient air pollution and cognitive decline differed by APOE-e4 status and cognitive risk factors. Methods The Washington Heights...
1 CitationsSource
#1Neika SharifianH-Index: 2
#2Yian GuH-Index: 25
Last. Laura B. ZahodneH-Index: 21
view all 7 authors...
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#1Bessie C Stamm (Columbia University)
#2Patrick J. Lao (Columbia University)H-Index: 7
Last. Adam M. Brickman (Columbia University)H-Index: 58
view all 11 authors...
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#1Indira C. Turney (CUMC: Columbia University Medical Center)
#2Miguel Arce Rentería (CUMC: Columbia University Medical Center)
Last. Jennifer J. Manly (CUMC: Columbia University Medical Center)H-Index: 20
view all 8 authors...
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#1Eric M. Reiman (ASU: Arizona State University)H-Index: 97
#2Joseph F. Arboleda-Velasquez (Harvard University)H-Index: 13
Last. Gyungah Jun (BU: Boston University)H-Index: 28
view all 41 authors...
Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer9s dementia, such that APOE4 homozygotes have a particularly high risk. While the APOE2 allele is associated with a lower risk of Alzheimer9s dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk. We generated Alzheimers dementia odds ratios and other findings in more than 5,000 clinically characterized and neuropathologically characterized Alzheimer9s dementia...
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