Genome‐wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways

Variability exists in the disease trajectories of Alzheimer's disease (AD) patients. We performed a genome-wide association study to examine rate of cognitive decline (ROD) in patients with AD.We tested for interactions between genetic variants and time since diagnosis to predict the ROD of a composite cognitive score in 3946 AD cases and performed pathway analysis on the top genes.Suggestive associations (P < 1.0 × 10-6 ) were observed on...