Match!
Richard Sherva
Boston University
Genome-wide association studyPsychiatrySingle-nucleotide polymorphismGeneticsBiology
84Publications
28H-index
2,782Citations
What is this?
Publications 91
Newest
#1Hang Zhou (Yale University)H-Index: 6
#2Christopher T. Rentsch (Yale University)H-Index: 8
Last. Renato Polimanti (Yale University)H-Index: 21
view all 14 authors...
Importance With the current opioid crisis, it is important to improve understanding of the biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk variants for OUD and determine genetic correlations and causal association with OUD and other traits. Design, Setting, and Participants A genome-wide association study of electronic health record–defined OUD in the Million Veteran Program sample was conducted, comprising 8529 affected European American individuals and 71 ...
Source
#1Jiayi Wu Cox (BU: Boston University)H-Index: 1
#2Richard Sherva (BU: Boston University)H-Index: 28
Last. Lindsay A. Farrer (BU: Boston University)H-Index: 87
view all 8 authors...
Source
#1Melissa A. Munn-Chernoff (UNC: University of North Carolina at Chapel Hill)H-Index: 10
#2Emma C. Johnson (WashU: Washington University in St. Louis)H-Index: 3
Last. Scott D. Gordon (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 41
view all 352 authors...
Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenoty...
Source
#1Bryan C. Quach (RTP: Research Triangle Park)H-Index: 1
#2Michael J. Bray (UW: University of Washington)
Last. Dana B. Hancock (RTP: Research Triangle Park)H-Index: 23
view all 44 authors...
Cigarette smoking is the leading cause of preventable morbidity and mortality. Knowledge is evolving on genetics underlying initiation, regular smoking, nicotine dependence (ND), and cessation. We performed a genome-wide association study using the Fagerstrom Test for ND (FTND) in 58,000 smokers of European or African ancestry. Five genome-wide significant loci, including two novel loci MAGI2/GNAI1 (rs2714700) and TENM2 (rs1862416) were identified, and loci reported for other smoking traits were...
Source
#1Jiayi Wu CoxH-Index: 1
#2Richard ShervaH-Index: 28
Last. Lindsay A. FarrerH-Index: 87
view all 11 authors...
The United States is experiencing an epidemic of opioid use disorder (OUD) and overdose-related deaths. However, the genetic basis for the ability to discontinue opioid use has not been investigated. We performed a genome-wide association study (GWAS) of opioid cessation (defined as abstinence from illicit opioids for >1 year or <6 months before the interview date) in 1130 African American (AA) and 2919 European ancestry (EA) participants recruited for genetic studies of substance use disorders ...
Source
#1Andries T. Marees (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 3
#2Eric R. Gamazon (University of Cambridge)H-Index: 39
Last. Eske M. Derks (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 37
view all 13 authors...
Abstract Background Little is known about the functional mechanisms through which genetic loci associated with substance use traits ascertain their effect. This study aims to identify and functionally annotate loci associated with substance use traits based on their role in genetic regulation of gene expression. Methods We evaluated expression Quantitative Trait Loci (eQTLs) from 13 brain regions and whole blood of the Genotype-Tissue Expression (GTEx) database, and from whole blood of the Depre...
Source
#1Andries T. MareesH-Index: 3
#2Eric R. GamazonH-Index: 39
Last. Richard ShervaH-Index: 28
view all 88 authors...
#2Emma C. JohnsonH-Index: 3
Last. Scott D. GordonH-Index: 41
view all 352 authors...
#1Melissa A. Munn-Chernoff (UNC: University of North Carolina at Chapel Hill)H-Index: 10
#2Emma C. Johnson (WashU: Washington University in St. Louis)H-Index: 3
Last. Arpana Agrawal (WashU: Washington University in St. Louis)H-Index: 50
view all 352 authors...
Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa (BN) and problem alcohol use (genetic correlation [rg], twin-based=0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phen...
1 CitationsSource
#1Jiayi Wu Cox (BU: Boston University)H-Index: 1
#2Richard Sherva (BU: Boston University)H-Index: 28
Last. Lindsay A. Farrer (BU: Boston University)H-Index: 87
view all 8 authors...
People with opioid use disorder (OUD) can stop using opioids on their own, with help from groups and with treatment, but there is limited research on the factors that influence opioid cessation. We employed multiple machine learning prediction algorithms (LASSO, random forest, deep neural network, and support vector machine) to assess factors associated with ceasing opioid use in a sample comprised of African Americans (AAs) and European Americans (EAs) who met DSM-5 criteria for mild to severe ...
Source
12345678910