von Willebrand factor increases in experimental cerebral malaria but is not essential for late‐stage pathogenesis in mice

Cerebral malaria (CM) is the most severe complication of malaria. Endothelial activation, cytokine release, and vascular obstruction are essential hallmarks of CM. Clinical studies have suggested a link between von Willebrand factor (VWF) and malaria pathology.To investigate the contribution of VWF in the pathogenesis of experimental cerebral malaria (ECM).Both Vwf+/+ and Vwf-/- mice were infected with Plasmodium berghei ANKA (PbANKA) to induce...