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Journal of Thrombosis and Haemostasis
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#1X. Long ZhengH-Index: 26
#2Sara K. Vesely (University of Oklahoma Health Sciences Center)H-Index: 50
Last. Gail Rock (U of O: University of Ottawa)H-Index: 35
view all 14 authors...
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#1Shuai Tan (KI: Karolinska Institutet)H-Index: 1
#2Shuijie Li (KI: Karolinska Institutet)H-Index: 4
Last. Miao Wang (Peking Union Medical College)
view all 16 authors...
BACKGROUND Cell metabolism drives T cell functions, while platelets regulate overall CD4+ T cell immune responses. OBJECTIVE To investigate if platelets influence cell metabolism and thus regulate CD4+ T effector memory cell (Tem) responses. METHODS Human CD4+ Tem cells were activated with αCD3/αCD28, and cultured without or with platelets or platelet-derived mediators. RESULTS Polyclonal stimulation induced rapid and marked Th1 and Treg cell activation of CD4+ Tem cells. Platelet co-culture enh...
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BACKGROUND The role of combined prothrombotic genotypes in cancer-related venous thromboembolism (VTE) is scarcely studied. We aimed to investigate the impact of a 5-single nucleotide polymorphisms (SNP) score on the risk of VTE in patients with and without cancer using a population-based case-cohort. METHODS Cases with a first VTE (n=1493) and a subcohort (n=13 072) were derived from the Tromso Study (1994-2012) and the Nord-Trondelag Health Study (1995-2008). Five SNPs previously reported as a...
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#1X. Long Zheng (KU: University of Kansas)H-Index: 26
#2Sara K. Vesely (University of Oklahoma Health Sciences Center)H-Index: 50
Last. Gail Rock (U of O: University of Ottawa)H-Index: 35
view all 14 authors...
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#1Christophe NougierH-Index: 6
Last. Yesim Dargaud (UCBL: Claude Bernard University Lyon 1)H-Index: 24
view all 10 authors...
BACKGROUND: Thirty percent of Covid-19 patients admitted to intensive care units present with thrombotic complications despite thromboprophylaxis. Bed resting, obesity, hypoxia, coagulopathy, acute excessive inflammation are potential mechanisms reported by previous studies. Better understanding of the underlying mechanisms leading to thrombosis is crucial for developing more appropriate prophylaxis and treatment strategies. OBJECTIVE: We aimed to assess fibrinolytic activity and thrombin genera...
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#1Maria Daglas (Monash University)H-Index: 8
#2Adam Galle (Monash University)H-Index: 4
Last. Robert L. Medcalf (Monash University)H-Index: 36
view all 7 authors...
BACKGROUND Tranexamic acid (TXA) is an anti-fibrinolytic agent used to reduce bleeding in various conditions including traumatic brain injury (TBI). As the fibrinolytic system also influences the central nervous system and the immune response, TXA may also modulate these parameters following TBI. OBJECTIVES To determine the effect of TXA on blood-brain barrier (BBB) integrity and changes in immune and motor function in male and female mice subjected to TBI. METHODS Wild-type and plasminogen defi...
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#1Wolfgang Schramm (LMU: Ludwig Maximilian University of Munich)H-Index: 34
Last. Lutz GürtlerH-Index: 18
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ABSTRACT We are overwhelmed by scientific publications on clinical observations, virology and epidemiology of SARS-CoV-2 infections There is a growing body of evidence that hypercoagulability complicates COVID-19, probably contributing to poor prognosis
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#1Shauna L. FrenchH-Index: 6
#2Prakrith Vijey (Brigham and Women's Hospital)H-Index: 3
Last. Joseph E. Italiano (Boston Children's Hospital)H-Index: 50
view all 10 authors...
BACKGROUND The mechanisms that regulate platelet biogenesis remain unclear; factors that trigger megakaryocytes (MKs) to initiate platelet production are poorly understood. Platelet formation begins with proplatelets which are cellular extensions originating from the MK cell body. OBJECTIVES Proplatelet formation is an asynchronous and dynamic process which poses unique challenges for researchers to accurately capture and analyze. We have designed an open-source, high-content, high-throughput, l...
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#1Jecko Thachil (University of Manchester)H-Index: 6
#2Nicole P. Juffermans (UvA: University of Amsterdam)H-Index: 37
Last. Jerrold H. Levy (Duke University)H-Index: 65
view all 9 authors...
Abstract Hypercoagulability is an increasingly recognized complication of SARS-CoV-2 infection As such, anticoagulation has become part and parcel of comprehensive COVID-19 management However, several uncertainties exist in this area including the appropriate type and dose of heparin In addition, special patient populations, including those with high body mass index and renal impairment, require special consideration Although the current evidence is still insufficient, we provide a pragmatic app...
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#1Lindsey A. Miles (Scripps Research Institute)H-Index: 42
#2Juliana P. Vago (Scripps Research Institute)H-Index: 13
Last. Robert J. Parmer (VA: United States Department of Veterans Affairs)H-Index: 38
view all 4 authors...
Plg-RKT , is a structurally unique transmembrane plasminogen receptor with both N- and C-terminal domains exposed on the extracellular face of the cell. Its C-terminal lysine functions to tether plasminogen to cell surfaces. Over expression of Plg-RKT increases cell surface plasminogen binding capacity while genetic deletion of Plg-RKT decreases plasminogen binding. Plasminogen binding to Plg-RKT results in promotion of plasminogen activation to the broad spectrum serine protease, plasmin. This ...
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