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Sirima Kraisin
Katholieke Universiteit Leuven
Internal medicineMalariaVon Willebrand factorDiabetes mellitusMedicine
2Publications
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Publications 2
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#1Sirima Kraisin (Katholieke Universiteit Leuven)H-Index: 1
#2Kimberly Martinod (Katholieke Universiteit Leuven)H-Index: 22
Last. Simon F. De Meyer (Katholieke Universiteit Leuven)H-Index: 24
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BACKGROUND Cerebral malaria (CM) is the most severe complication in malaria. Endothelial activation, cytokine release and vascular obstruction are essential hallmarks of CM. Clinical studies have suggested a link between von Willebrand factor (VWF) and malaria pathology. OBJECTIVES To investigate the contribution of VWF in the pathogenesis of experimental cerebral malaria (ECM). METHODS Both Vwf+/+ and Vwf-/- mice were infected with Plasmodium berghei ANKA (PbANKA) to induce ECM. Alterations of ...
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#1Sirima Kraisin (Katholieke Universiteit Leuven)H-Index: 1
#2Sebastien Verhenne (Katholieke Universiteit Leuven)H-Index: 6
Last. Simon F. DeMeyer (Katholieke Universiteit Leuven)H-Index: 22
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BACKGROUND: Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a lethal complication of severe malaria, characterized by marked pulmonary inflammation. Patient studies have suggested a link between von Willebrand factor (VWF) and malaria severity. OBJECTIVES: To investigate the role of VWF in the pathogenesis of experimental MA-ARDS. METHODS: Plasmodium berghei NK65-E (PbNK65) parasites were injected in Vwf+/+ and Vwf-/- mice. Pathological parameters were assessed following infe...
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