Kimberly Martinod
Katholieke Universiteit Leuven
Neutrophil extracellular trapsImmunologyThrombosisMedicineBiology
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Publications 47
#1Marijke Peetermans (Katholieke Universiteit Leuven)H-Index: 13
#2Severien Meyers (Katholieke Universiteit Leuven)H-Index: 1
Last. Peter Verhamme (Katholieke Universiteit Leuven)H-Index: 32
view all 12 authors...
BACKGROUND: Previous clinical evidence correlates levels of von Willebrand factor (VWF) and its cleaving protease ADAMTS13 with outcome in septic patients. No previous studies addressed if VWF and ADAMTS13 affected the outcome of Staphylococcus aureus sepsis. OBJECTIVES: We studied the role of VWF and ADAMTS13 in S. aureus sepsis both in patients and in mice. METHODS: VWF levels and ADAMTS13 activity levels were measured in plasma samples from 89 S. aureus bacteremia patients by chemiluminescent...
1 CitationsSource
#1Frederik DenormeH-Index: 9
#2Kimberly MartinodH-Index: 21
Last. Simon F. DeMeyerH-Index: 22
view all 8 authors...
von Willebrand factor (VWF) plays an important role in ischemic stroke. However, the exact mechanism by which VWF mediates progression of ischemic stroke brain damage is not completely understood. Using flow cytometric analysis of single cell suspensions prepared from brain tissue and immunohistochemistry, we investigated the potential inflammatory mechanisms by which VWF contributes to ischemic stroke brain damage in a mouse model of cerebral ischemia/reperfusion injury. Twenty-four hours after...
#1Severien Meyers (Katholieke Universiteit Leuven)H-Index: 1
#2Laurens Liesenborghs (Katholieke Universiteit Leuven)H-Index: 9
Last. Kimberly Martinod (Katholieke Universiteit Leuven)H-Index: 21
view all 7 authors...
#1Nicoletta Sorvillo (Harvard University)H-Index: 10
#2Daniella M. Mizurini (Harvard University)H-Index: 1
Last. Denisa D. Wagner (Harvard University)H-Index: 103
view all 14 authors...
Rationale: PAD4 (peptidylarginine deiminase type IV), an enzyme essential for neutrophil extracellular trap formation (NETosis), is released together with neutrophil extracellular traps into the ex...
4 CitationsSource
#1Nicoletta Sorvillo (Harvard University)H-Index: 10
#2Deya Cherpokova (Harvard University)H-Index: 9
Last. Denisa D. Wagner (Harvard University)H-Index: 103
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Neutrophils play a central role in innate immune defense. Advances in neutrophil biology have brought to light the capacity of neutrophils to release their decondensed chromatin and form large extr...
2 CitationsSource
#1Sirima Kraisin (Katholieke Universiteit Leuven)
#2Sebastien Verhenne (Katholieke Universiteit Leuven)H-Index: 5
Last. Simon F. DeMeyer (Katholieke Universiteit Leuven)H-Index: 22
view all 10 authors...
#1Elodie Laridan (Katholieke Universiteit Leuven)H-Index: 2
#2Kimberly Martinod (Katholieke Universiteit Leuven)H-Index: 21
Last. Simon F. DeMeyer (Katholieke Universiteit Leuven)H-Index: 22
view all 3 authors...
Thrombotic complications are still a major health risk worldwide. Our view on the pathophysiology of thrombosis has significantly changed since the discovery of neutrophil extracellular traps (NETs) and their prothrombotic characteristics. Generated by neutrophils that release their decondensed chromatin as a network of extracellular fibers, NETs promote thrombus formation by serving as a scaffold that activates platelets and coagulation. The thrombogenic involvement of NETs has been described i...
5 CitationsSource
#1Mélanie DemersH-Index: 20
#2Georgette L. SuidanH-Index: 11
Last. Denisa D. WagnerH-Index: 103
view all 6 authors...
#1Irina Portier (Katholieke Universiteit Leuven)H-Index: 2
#2Kimberly Martinod (Katholieke Universiteit Leuven)H-Index: 21
Last. Simon F. De Meyer (Katholieke Universiteit Leuven)H-Index: 13
view all 7 authors...
Abdominal aortic aneurysm (AAA) refers to a localized dilation of the abdominal aorta that exceeds the normal diameter by 50%. AAA pathophysiology is characterized by progressive inflammation, vessel wall destabilization and thrombus formation. Our aim was to investigate the potential involvement of von Willebrand factor (VWF), a thrombo-inflammatory plasma protein, in AAA pathophysiology using a dissection-based and angiotensin II infusion-induced AAA mouse model. AAA formation was induced in b...
1 CitationsSource
#1Nandini Krishnamoorthy (Brigham and Women's Hospital)H-Index: 14
#2David N. Douda (Brigham and Women's Hospital)H-Index: 14
Last. Bruce D. Levy (Brigham and Women's Hospital)H-Index: 53
view all 23 authors...
Severe asthma is a debilitating and treatment refractory disease. As many as half of these patients have complex neutrophil-predominant lung inflammation that is distinct from milder asthma with type 2 eosinophilic inflammation. New insights into severe asthma pathogenesis are needed. Concomitant exposure of mice to an aeroallergen and endotoxin during sensitization resulted in complex neutrophilic immune responses to allergen alone during later airway challenge. Unlike allergen alone, sensitiza...
21 CitationsSource