Review paper
“LRRK2: Autophagy and Lysosomal Activity”
Abstract
It has been 15 years since the Leucine-rich repeat kinase 2 (LRRK2) gene was identified as the most common genetic cause for Parkinson’s disease (PD). The two most common mutations are the LRRK2-G2019S, located in the kinase domain, and the LRRK2-R1441C, located in the ROC-COR domain. While the LRRK2-G2019S mutation is associated with increased kinase activity, the LRRK2-R1441C exhibits a decreased GTPase activity and altered kinase activity....
Paper Details
Title
“LRRK2: Autophagy and Lysosomal Activity”
Published Date
May 25, 2020
Journal
Volume
14
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Notes
History