#1Chaozhen Tan(HUST: Huazhong University of Science and Technology)H-Index: 1
#2Yue Guan(HUST: Huazhong University of Science and Technology)H-Index: 1
Last. Luo Qingming(HUST: Huazhong University of Science and Technology)H-Index: 45
view all 11 authors...
The segmentation of brain region contours in three-dimensions is critical for the analysis of different brain structures, and advanced approaches are emerging continuously within the field of neurosciences. With the development of high-resolution micro-optical imaging, whole-brain images can be acquired at the cellular level. However, brain regions in microscopic images are aggregated by discrete neurons with blurry boundaries, the complex and variable features of brain regions make it challengi...
Cerebellar ataxias (CAs) consist of a heterogeneous group of neurodegenerative diseases hallmarked by motor deficits and deterioration of the cerebellum and its associated circuitries. Neuroinflammatory responses are present in CA brain, but how neuroinflammation may contribute to CA pathogenesis remain unresolved. Here, we investigate whether transforming growth factor (TGF)‐β1, which possesses anti‐inflammatory and neuroprotective properties, can ameliorate the microglia-mediated neuroinflamma...
We have applied a novel and integrative analysis framework for next-generation sequencing (NGS) data to 503 human subjects provided by the Religious Orders Study and Memory and Aging Project (ROSMAP) to examine changes in transcriptomic organization and common variants in association with late-onset Alzheimer’s disease (Wijsman et al.). Our framework identified seven reproducible, co-regulated modules after quality control, clinical segregation, preservation filtering, and functional ontology an...